{"id":"https://openalex.org/W2102281059","doi":"https://doi.org/10.1109/cdc.2012.6426858","title":"Simulated mid-ranging control of propofol and remifentanil using EEG-measured hypnotic depth of anesthesia","display_name":"Simulated mid-ranging control of propofol and remifentanil using EEG-measured hypnotic depth of anesthesia","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2102281059","doi":"https://doi.org/10.1109/cdc.2012.6426858","mag":"2102281059"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2012.6426858","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2012.6426858","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 51st IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lup.lub.lu.se/record/3048310","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087697079","display_name":"Kristian Soltesz","orcid":"https://orcid.org/0000-0001-6378-7646"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Kristian Soltesz","raw_affiliation_strings":["Department of Automatic Control, Lund University, Lund, Sweden","Department of Automatic Control, Lund University, Sweden#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Automatic Control, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Department of Automatic Control, Lund University, Sweden#TAB#","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055045540","display_name":"Guy A. Dumont","orcid":"https://orcid.org/0000-0003-2048-4391"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Guy A. Dumont","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada","Dept of Electrical & Computer Engineering, University of British Columbia, Vancouver, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Dept of Electrical & Computer Engineering, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009577016","display_name":"Klaske van Heusden","orcid":"https://orcid.org/0000-0003-2763-5279"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Klaske van Heusden","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada","Dept of Electrical & Computer Engineering, University of British Columbia, Vancouver, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Dept of Electrical & Computer Engineering, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036187563","display_name":"Tore H\u00e4gglund","orcid":"https://orcid.org/0000-0002-1489-0994"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Tore Hagglund","raw_affiliation_strings":["Department of Automatic Control, Lund University, Lund, Sweden","Department of Automatic Control, Lund University, Sweden#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Automatic Control, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Department of Automatic Control, Lund University, Sweden#TAB#","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010534406","display_name":"J. Mark Ansermino","orcid":"https://orcid.org/0000-0001-8427-2035"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Mark Ansermino","raw_affiliation_strings":["Department of Anesthesiology Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada","\u00b6Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"\u00b6Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5087697079"],"corresponding_institution_ids":["https://openalex.org/I187531555"],"apc_list":null,"apc_paid":null,"fwci":0.6825,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.71802634,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"356","last_page":"361"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/remifentanil","display_name":"Remifentanil","score":0.9050063490867615},{"id":"https://openalex.org/keywords/propofol","display_name":"Propofol","score":0.8064393997192383},{"id":"https://openalex.org/keywords/hypnotic","display_name":"Hypnotic","score":0.6721398234367371},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.6610047817230225},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.42845243215560913},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3744595944881439},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.32338660955429077}],"concepts":[{"id":"https://openalex.org/C2778891214","wikidata":"https://www.wikidata.org/wiki/Q417902","display_name":"Remifentanil","level":3,"score":0.9050063490867615},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.8064393997192383},{"id":"https://openalex.org/C2780930544","wikidata":"https://www.wikidata.org/wiki/Q62962","display_name":"Hypnotic","level":2,"score":0.6721398234367371},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6610047817230225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42845243215560913},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3744595944881439},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32338660955429077}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/cdc.2012.6426858","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2012.6426858","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 51st IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},{"id":"pmh:oai:lup.lub.lu.se:0b71d0f9-cc49-49ff-bc1e-b63d037c444e","is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/3048310","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0191-2216","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:lup.lub.lu.se:0b71d0f9-cc49-49ff-bc1e-b63d037c444e","is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/3048310","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0191-2216","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8399999737739563}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1532361062","https://openalex.org/W1581701214","https://openalex.org/W1977388322","https://openalex.org/W1986855353","https://openalex.org/W1987117563","https://openalex.org/W1993063736","https://openalex.org/W2003873779","https://openalex.org/W2017309204","https://openalex.org/W2018799133","https://openalex.org/W2019879739","https://openalex.org/W2035230043","https://openalex.org/W2037348596","https://openalex.org/W2039026063","https://openalex.org/W2042613429","https://openalex.org/W2043742363","https://openalex.org/W2112317686","https://openalex.org/W2127539685","https://openalex.org/W2145996826","https://openalex.org/W2316997395","https://openalex.org/W2488700677","https://openalex.org/W2616834331","https://openalex.org/W6634989633"],"related_works":["https://openalex.org/W2369704159","https://openalex.org/W2466096929","https://openalex.org/W2350247811","https://openalex.org/W2388342822","https://openalex.org/W2359589008","https://openalex.org/W1974348264","https://openalex.org/W2003339380","https://openalex.org/W2502942571","https://openalex.org/W2072665752","https://openalex.org/W1993372844"],"abstract_inverted_index":{"This":[0],"paper":[1],"suggests":[2],"an":[3,6],"extension":[4,21],"of":[5,25,54,62,93,103,116],"existing,":[7],"clinically":[8],"evaluated,":[9],"closed-loop":[10,23],"drug":[11,28],"delivery":[12],"system":[13,106,128],"for":[14,107],"hypnotic":[15,70,81,108],"depth":[16,71,82,109],"control":[17,37,53,105,118,127],"using":[18],"propofol.":[19,51],"The":[20,91],"introduces":[22],"administration":[24],"the":[26,59,79,99,104,112],"analgesic":[27],"remifentanil,":[29],"thus":[30],"forming":[31],"a":[32,45,63,121,125,140,150],"multiple":[33],"input-single":[34],"output":[35],"(MISO)":[36],"system.":[38],"Remifentanil":[39],"acts":[40],"and":[41,131,144],"is":[42,56,147],"metabolized":[43],"at":[44],"significantly":[46],"faster":[47],"time":[48],"scale":[49],"than":[50],"Direct":[52],"analgesia":[55],"hindered":[57],"by":[58,86,110],"current":[60],"absence":[61],"reliable":[64],"real-time":[65],"nociception":[66],"monitor.":[67],"However,":[68],"several":[69],"monitors":[72],"respond":[73],"to":[74,120],"nociception.":[75],"Sudden":[76],"changes":[77,87],"in":[78,88,97],"measured":[80],"are":[83],"frequently":[84],"caused":[85],"noxious":[89],"stimulation.":[90],"novelty":[92],"this":[94],"work":[95],"lies":[96],"increasing":[98],"disturbance":[100],"rejection":[101],"bandwidth":[102],"directing":[111],"high":[113],"frequency":[114],"content":[115],"its":[117,145],"error":[119],"remifentanil":[122],"controller.":[123],"Such":[124],"mid-ranging":[126],"was":[129],"implemented":[130],"tuned":[132],"based":[133],"on":[134],"23":[135],"patient":[136],"models":[137],"obtained":[138],"from":[139],"previous":[141],"clinical":[142],"study":[143],"performance":[146],"demonstrated":[148],"through":[149],"simulation":[151],"study.":[152]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
