{"id":"https://openalex.org/W2086887097","doi":"https://doi.org/10.1109/cdc.2012.6426531","title":"Fold-change detection as a chemotaxis model discrimination tool","display_name":"Fold-change detection as a chemotaxis model discrimination tool","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2086887097","doi":"https://doi.org/10.1109/cdc.2012.6426531","mag":"2086887097"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2012.6426531","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2012.6426531","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 51st IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044539045","display_name":"Abdullah Hamadeh","orcid":"https://orcid.org/0000-0002-9419-1797"},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Abdullah Hamadeh","raw_affiliation_strings":["Department of Applied Mathematics, University of Waterloo, Waterloo, ONT, Canada","Department of Applied Mathematics, University of Waterloo, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics, University of Waterloo, Waterloo, ONT, Canada","institution_ids":["https://openalex.org/I151746483"]},{"raw_affiliation_string":"Department of Applied Mathematics, University of Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014787617","display_name":"Brian Ingalls","orcid":"https://orcid.org/0000-0003-2118-3881"},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Brian Ingalls","raw_affiliation_strings":["Department of Applied Mathematics, University of Waterloo, Waterloo, ONT, Canada","Department of Applied Mathematics, University of Waterloo, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics, University of Waterloo, Waterloo, ONT, Canada","institution_ids":["https://openalex.org/I151746483"]},{"raw_affiliation_string":"Department of Applied Mathematics, University of Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068753451","display_name":"Eduardo D. Sontag","orcid":"https://orcid.org/0000-0001-8020-5783"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo Sontag","raw_affiliation_strings":["Department of Mathematics, Rutgers University, Piscataway, NJ, USA","Department of Mathematics, Rutgers University, Piscataway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Rutgers University, Piscataway, NJ, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Mathematics, Rutgers University, Piscataway, New Jersey, USA","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.10766054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"3","issue":null,"first_page":"5523","last_page":"5527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9905999898910522,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhodobacter-sphaeroides","display_name":"Rhodobacter sphaeroides","score":0.9170406460762024},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"Chemotaxis","score":0.8796873092651367},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.6094086170196533},{"id":"https://openalex.org/keywords/property","display_name":"Property (philosophy)","score":0.5971238613128662},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5375902652740479},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5040075182914734},{"id":"https://openalex.org/keywords/transient","display_name":"Transient (computer programming)","score":0.5017232894897461},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.4489367604255676},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20308509469032288},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.10365083813667297}],"concepts":[{"id":"https://openalex.org/C2777897970","wikidata":"https://www.wikidata.org/wiki/Q4186823","display_name":"Rhodobacter sphaeroides","level":3,"score":0.9170406460762024},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.8796873092651367},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.6094086170196533},{"id":"https://openalex.org/C189950617","wikidata":"https://www.wikidata.org/wiki/Q937228","display_name":"Property (philosophy)","level":2,"score":0.5971238613128662},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5375902652740479},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5040075182914734},{"id":"https://openalex.org/C2780799671","wikidata":"https://www.wikidata.org/wiki/Q17087362","display_name":"Transient (computer programming)","level":2,"score":0.5017232894897461},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.4489367604255676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20308509469032288},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.10365083813667297},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc.2012.6426531","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2012.6426531","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 51st IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.5099999904632568,"display_name":"Reduced inequalities"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320338279","display_name":"Air Force Office of Scientific Research","ror":"https://ror.org/011e9bt93"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1992717202","https://openalex.org/W1994217704","https://openalex.org/W1998093640","https://openalex.org/W2046649943","https://openalex.org/W2072454019","https://openalex.org/W2076847255","https://openalex.org/W2077919298","https://openalex.org/W2084092304","https://openalex.org/W2087537613","https://openalex.org/W2090018132","https://openalex.org/W2117056464","https://openalex.org/W2126596902","https://openalex.org/W2131591423","https://openalex.org/W2133254839","https://openalex.org/W2150217382","https://openalex.org/W2155465948","https://openalex.org/W2964163153","https://openalex.org/W4293496959"],"related_works":["https://openalex.org/W2938527599","https://openalex.org/W2968255614","https://openalex.org/W44045117","https://openalex.org/W4231595554","https://openalex.org/W2503804969","https://openalex.org/W4300030230","https://openalex.org/W2050104727","https://openalex.org/W4213024209","https://openalex.org/W2296952171","https://openalex.org/W1964563046"],"abstract_inverted_index":{"Fold-change":[0],"detection":[1],"(FCD)":[2],"is":[3,63,165,193],"the":[4,32,36,48,53,74,108,111,132,157,160,186,203],"property":[5,143,172],"that":[6,58,68,90,131,156,159,221],"a":[7,102,141,179,213],"dynamical":[8],"system":[9],"with":[10,150],"an":[11,121],"adapting":[12],"output":[13,18],"will":[14],"exhibit":[15,95],"identical":[16],"transient":[17,170,189],"responses":[19],"when":[20],"its":[21],"input":[22],"signals":[23],"are":[24,136,230],"scaled.":[25],"This":[26,192],"feature":[27],"was":[28],"recently":[29],"demonstrated":[30],"in":[31,59,67,148,194],"chemotactic":[33],"response":[34],"of":[35,47,73,104,110,144,188,205,216,226],"bacterium":[37,49],"Escherichia":[38],"coli,":[39],"confirming":[40],"earlier":[41,174,197],"theoretical":[42,105,228],"predictions.":[43],"The":[44],"chemotaxis":[45,76,123,146],"pathway":[46],"Rhodobacter":[50],"sphaeroides":[51,92,113],"has":[52,70],"same":[54],"modular":[55],"structure":[56],"as":[57],"E.":[60],"coli":[61],"but":[62],"significantly":[64],"more":[65],"complex":[66],"it":[69],"multiple":[71],"homologues":[72],"latter's":[75],"proteins":[77],"and":[78,116],"features":[79],"two,":[80],"rather":[81],"than":[82],"one,":[83],"chemosensory":[84,114],"cluster.":[85],"Recent":[86],"experimental":[87,126,152,217],"results":[88],"suggest":[89],"R.":[91,112],"may":[93],"also":[94],"FCD.":[96],"In":[97],"this":[98,145,169],"paper,":[99],"we":[100,134,162],"present":[101,163],"set":[103,215],"assumptions":[106,133,229],"on":[107,185,208],"dynamics":[109],"system,":[115],"use":[117],"these":[118],"to":[119,125,138,167,196,211],"fit":[120],"integrated":[122],"model":[124,161,183,198],"data.":[127,218],"We":[128,154],"then":[129],"show":[130],"place":[135],"sufficient":[137],"make":[139],"FCD":[140,178],"robust":[142],"pathway,":[147],"agreement":[149],"preliminary":[151],"evidence.":[153],"argue":[155],"fact":[158],"here":[164],"able":[166],"reproduce":[168,212],"dynamic":[171,190],"whilst":[173],"models":[175,206],"cannot":[176],"makes":[177],"useful":[180],"tool":[181],"for":[182],"discrimination":[184,199],"basis":[187],"response.":[191],"contrast":[195],"methods":[200],"which":[201],"tested":[202],"validity":[204],"based":[207],"their":[209],"ability":[210],"finite":[214],"Further":[219],"experiments":[220],"can":[222],"provide":[223],"additional":[224],"validation":[225],"our":[227],"suggested.":[231]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}