{"id":"https://openalex.org/W2086901266","doi":"https://doi.org/10.1109/cdc.2012.6426064","title":"On the role of ultrasensitivity in biomolecular control systems","display_name":"On the role of ultrasensitivity in biomolecular control systems","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2086901266","doi":"https://doi.org/10.1109/cdc.2012.6426064","mag":"2086901266"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2012.6426064","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2012.6426064","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 51st IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036698807","display_name":"Francesco Montefusco","orcid":"https://orcid.org/0000-0002-3264-9686"},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Francesco Montefusco","raw_affiliation_strings":["Centre for Systems, Dynamics and Control, College of Engineering, Mathematics and Physical Sciences, University of Exeter, UK"],"affiliations":[{"raw_affiliation_string":"Centre for Systems, Dynamics and Control, College of Engineering, Mathematics and Physical Sciences, University of Exeter, UK","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065880807","display_name":"Arno Steinacher","orcid":null},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Arno Steinacher","raw_affiliation_strings":["Centre for Systems, Dynamics and Control, College of Engineering, Mathematics and Physical Sciences, University of Exeter, UK"],"affiliations":[{"raw_affiliation_string":"Centre for Systems, Dynamics and Control, College of Engineering, Mathematics and Physical Sciences, University of Exeter, UK","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014444761","display_name":"Ozgur E. Akman","orcid":"https://orcid.org/0000-0002-9320-5958"},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ozgur E. Akman","raw_affiliation_strings":["Centre for Systems, Dynamics and Control, College of Engineering, Mathematics and Physical Sciences, University of Exeter, UK"],"affiliations":[{"raw_affiliation_string":"Centre for Systems, Dynamics and Control, College of Engineering, Mathematics and Physical Sciences, University of Exeter, UK","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077819322","display_name":"Declan G. Bates","orcid":"https://orcid.org/0000-0003-1395-9846"},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Declan G. Bates","raw_affiliation_strings":["Centre for Systems, Dynamics and Control, College of Engineering, Mathematics and Physical Sciences, University of Exeter, UK"],"affiliations":[{"raw_affiliation_string":"Centre for Systems, Dynamics and Control, College of Engineering, Mathematics and Physical Sciences, University of Exeter, UK","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013739050","display_name":"Orkun S. Soyer","orcid":"https://orcid.org/0000-0002-9504-3796"},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Orkun S. Soyer","raw_affiliation_strings":["Centre for Systems, Dynamics and Control, College of Engineering, Mathematics and Physical Sciences, University of Exeter, UK"],"affiliations":[{"raw_affiliation_string":"Centre for Systems, Dynamics and Control, College of Engineering, Mathematics and Physical Sciences, University of Exeter, UK","institution_ids":["https://openalex.org/I23923803"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5036698807"],"corresponding_institution_ids":["https://openalex.org/I23923803"],"apc_list":null,"apc_paid":null,"fwci":0.1345,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5306949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"6","issue":null,"first_page":"3602","last_page":"3607"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9757000207901001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/controller","display_name":"Controller (irrigation)","score":0.6292414665222168},{"id":"https://openalex.org/keywords/automatic-gain-control","display_name":"Automatic gain control","score":0.6191198229789734},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5966532826423645},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.527077853679657},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.5115919709205627},{"id":"https://openalex.org/keywords/gain-scheduling","display_name":"Gain scheduling","score":0.4571431279182434},{"id":"https://openalex.org/keywords/control-system","display_name":"Control system","score":0.45588669180870056},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.43345656991004944},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.41506463289260864},{"id":"https://openalex.org/keywords/simple","display_name":"Simple (philosophy)","score":0.41405177116394043},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.391981303691864},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.18701431155204773},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14795950055122375},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.11336293816566467},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.08648917078971863},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.08330410718917847},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.07487013936042786}],"concepts":[{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.6292414665222168},{"id":"https://openalex.org/C177502760","wikidata":"https://www.wikidata.org/wiki/Q782524","display_name":"Automatic gain control","level":4,"score":0.6191198229789734},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5966532826423645},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.527077853679657},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.5115919709205627},{"id":"https://openalex.org/C97090092","wikidata":"https://www.wikidata.org/wiki/Q764612","display_name":"Gain scheduling","level":3,"score":0.4571431279182434},{"id":"https://openalex.org/C17500928","wikidata":"https://www.wikidata.org/wiki/Q959968","display_name":"Control system","level":2,"score":0.45588669180870056},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.43345656991004944},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.41506463289260864},{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.41405177116394043},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.391981303691864},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.18701431155204773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14795950055122375},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.11336293816566467},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08648917078971863},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.08330410718917847},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.07487013936042786},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C2776257435","wikidata":"https://www.wikidata.org/wiki/Q1576430","display_name":"Bandwidth (computing)","level":2,"score":0.0},{"id":"https://openalex.org/C194257627","wikidata":"https://www.wikidata.org/wiki/Q211554","display_name":"Amplifier","level":3,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1109/cdc.2012.6426064","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2012.6426064","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 51st IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.708.6745","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.708.6745","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://people.exeter.ac.uk/oea201/Montefusco12.pdf","raw_type":"text"},{"id":"pmh:oai:ricerca.uniparthenope.it:11367/101978","is_oa":false,"landing_page_url":"http://hdl.handle.net/11367/101978","pdf_url":null,"source":{"id":"https://openalex.org/S4377196432","display_name":"CINECA IRIS Institutial research information system (Parthenope University of Naples)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183638586","host_organization_name":"Parthenope University of Naples","host_organization_lineage":["https://openalex.org/I183638586"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:ricerca.uniparthenope.it:11367/101992","is_oa":false,"landing_page_url":"http://hdl.handle.net/11367/101992","pdf_url":null,"source":{"id":"https://openalex.org/S4377196432","display_name":"CINECA IRIS Institutial research information system (Parthenope University of Naples)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183638586","host_organization_name":"Parthenope University of Naples","host_organization_lineage":["https://openalex.org/I183638586"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:www.research.unipd.it:11577/2837101","is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/2837101","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G257826533","display_name":null,"funder_award_id":"EP/I017445/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1639032689","https://openalex.org/W1873774221","https://openalex.org/W1964047735","https://openalex.org/W1970247880","https://openalex.org/W2012226836","https://openalex.org/W2018010977","https://openalex.org/W2041603328","https://openalex.org/W2055621713","https://openalex.org/W2070658593","https://openalex.org/W2098199730","https://openalex.org/W2108380954","https://openalex.org/W2133254839","https://openalex.org/W2133403209","https://openalex.org/W2135326887","https://openalex.org/W2135535700","https://openalex.org/W2156906864","https://openalex.org/W2904250082","https://openalex.org/W3023540311","https://openalex.org/W6639118232","https://openalex.org/W6682786583"],"related_works":["https://openalex.org/W2072526354","https://openalex.org/W3141738981","https://openalex.org/W2099102792","https://openalex.org/W4254255930","https://openalex.org/W4377564965","https://openalex.org/W4205129443","https://openalex.org/W2009687716","https://openalex.org/W634364059","https://openalex.org/W4250188017","https://openalex.org/W2275391976"],"abstract_inverted_index":{"One":[0],"of":[1,14,28,48,68,73,121,127,140,156,195,203],"the":[2,12,15,25,29,46,57,71,79,101,119,125,128,173,192],"most":[3],"important":[4],"design":[5,210],"parameters":[6],"in":[7,31,50,62,77,197],"synthetic":[8,206],"biological":[9,21,134,198],"circuits":[10],"is":[11,35,83],"gain":[13,30,49,76,196],"system.":[16],"In":[17,37],"many":[18],"naturally":[19],"occurring":[20],"control":[22,34,42,212],"systems,":[23,199],"however,":[24,70],"precise":[26,152],"role":[27,47,72,194],"ensuring":[32],"accurate":[33],"unclear.":[36],"this":[38,63,116],"study,":[39],"we":[40,107],"employ":[41],"theory":[43],"to":[44,181,205,209],"explore":[45],"osmoregulation.":[51],"It":[52],"has":[53,88],"been":[54,89],"well-documented":[55],"that":[56,91,144],"upstream":[58],"signalling":[59],"pathways":[60],"involved":[61],"system":[64,117],"implement":[65],"high":[66,75,104],"levels":[67,139],"ultrasensitivity,":[69],"such":[74],"producing":[78],"observed":[80],"perfect":[81],"adaptation":[82,155],"not":[84],"clear.":[85],"Indeed,":[86],"it":[87],"argued":[90],"a":[92,109,145,170,184],"simple":[93],"integral":[94],"feedback":[95],"controller":[96,113,147,175],"can":[97,166],"explain":[98],"osmoadaptation":[99],"without":[100],"need":[102],"for":[103,115],"gain.":[105,141],"Here,":[106],"extend":[108],"recently":[110],"developed":[111],"proportional":[112,146,174],"model":[114],"with":[118],"implementation":[120],"ultrasenstivity.":[122],"We":[123,142],"evaluate":[124],"performance":[126],"resulting":[129],"two":[130],"controllers":[131],"under":[132],"different":[133,138],"assumptions":[135],"and":[136,153,177,200],"allowing":[137,179],"find":[143],"implementing":[148],"ultrasensitivity":[149],"allows":[150],"more":[151],"faster":[154],"cell":[157],"volume":[158],"following":[159],"an":[160,163],"osmo-shock.":[161],"Such":[162],"input-output":[164],"relationship":[165],"be":[167,202],"tuned":[168],"as":[169],"filter,":[171],"where":[172],"couldn't,":[176],"thereby":[178],"responses":[180],"signals":[182],"above":[183],"certain":[185],"threshold.":[186],"Our":[187],"results":[188],"provide":[189],"insights":[190],"on":[191],"potential":[193],"should":[201],"interest":[204],"biologists":[207],"attempting":[208],"biomolecular":[211],"systems.":[213]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}