{"id":"https://openalex.org/W2018063453","doi":"https://doi.org/10.1109/cdc.2012.6426023","title":"Systematically manipulating T-cell signaling dynamics via multiple model informed open-loop controller design","display_name":"Systematically manipulating T-cell signaling dynamics via multiple model informed open-loop controller design","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2018063453","doi":"https://doi.org/10.1109/cdc.2012.6426023","mag":"2018063453"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2012.6426023","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2012.6426023","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 51st IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016929935","display_name":"Jeffrey P. Perley","orcid":null},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey P. Perley","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN","Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47906 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47906 USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013685508","display_name":"Judith Mikolajczak","orcid":null},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith Mikolajczak","raw_affiliation_strings":["Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, IN","Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, IN 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, IN 47906, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113906281","display_name":"Vu C. Dinh","orcid":null},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vu C. Dinh","raw_affiliation_strings":["Department of Mathematics, Purdue University, West Lafayette, IN","Department of Mathematics, Purdue University, West Lafayette, IN 47906 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Purdue University, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Mathematics, Purdue University, West Lafayette, IN 47906 USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032608954","display_name":"Marietta L. Harrison","orcid":null},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marietta L. Harrison","raw_affiliation_strings":["Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, IN","Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, IN 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, IN 47906, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020010248","display_name":"Gregery T. Buzzard","orcid":"https://orcid.org/0000-0001-9777-3090"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregery T. Buzzard","raw_affiliation_strings":["Department of Mathematics, Purdue University, West Lafayette, IN","Department of Mathematics, Purdue University, West Lafayette, IN 47906 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Purdue University, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Mathematics, Purdue University, West Lafayette, IN 47906 USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048545593","display_name":"Ann E. Rundell","orcid":null},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann E. Rundell","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN","Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47906 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47906 USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1575514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"380","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/weighting","display_name":"Weighting","score":0.7095373272895813},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.6424278616905212},{"id":"https://openalex.org/keywords/open-loop-controller","display_name":"Open-loop controller","score":0.6262462735176086},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6245668530464172},{"id":"https://openalex.org/keywords/controller","display_name":"Controller (irrigation)","score":0.588927686214447},{"id":"https://openalex.org/keywords/akaike-information-criterion","display_name":"Akaike information criterion","score":0.4789586365222931},{"id":"https://openalex.org/keywords/model-predictive-control","display_name":"Model predictive control","score":0.4731501340866089},{"id":"https://openalex.org/keywords/trajectory","display_name":"Trajectory","score":0.4631243646144867},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.44126102328300476},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4313011169433594},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.38968920707702637},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.27158570289611816},{"id":"https://openalex.org/keywords/closed-loop","display_name":"Closed loop","score":0.2531115412712097},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.23046496510505676},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.172489732503891},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.17170315980911255}],"concepts":[{"id":"https://openalex.org/C183115368","wikidata":"https://www.wikidata.org/wiki/Q856577","display_name":"Weighting","level":2,"score":0.7095373272895813},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.6424278616905212},{"id":"https://openalex.org/C161362739","wikidata":"https://www.wikidata.org/wiki/Q2301555","display_name":"Open-loop controller","level":3,"score":0.6262462735176086},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6245668530464172},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.588927686214447},{"id":"https://openalex.org/C126674687","wikidata":"https://www.wikidata.org/wiki/Q1662573","display_name":"Akaike information criterion","level":2,"score":0.4789586365222931},{"id":"https://openalex.org/C172205157","wikidata":"https://www.wikidata.org/wiki/Q1782962","display_name":"Model predictive control","level":3,"score":0.4731501340866089},{"id":"https://openalex.org/C13662910","wikidata":"https://www.wikidata.org/wiki/Q193139","display_name":"Trajectory","level":2,"score":0.4631243646144867},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.44126102328300476},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4313011169433594},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.38968920707702637},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.27158570289611816},{"id":"https://openalex.org/C3019251811","wikidata":"https://www.wikidata.org/wiki/Q5135346","display_name":"Closed loop","level":2,"score":0.2531115412712097},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.23046496510505676},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.172489732503891},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.17170315980911255},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc.2012.6426023","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2012.6426023","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 51st IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W82980577","https://openalex.org/W1965694831","https://openalex.org/W1970321745","https://openalex.org/W2009435671","https://openalex.org/W2037909286","https://openalex.org/W2042431901","https://openalex.org/W2063903787","https://openalex.org/W2086262311","https://openalex.org/W2092755129","https://openalex.org/W2093684645","https://openalex.org/W2096248361","https://openalex.org/W2114159702","https://openalex.org/W2121567796","https://openalex.org/W2124630954","https://openalex.org/W2143854006","https://openalex.org/W2149069712","https://openalex.org/W2161263026","https://openalex.org/W4299498335"],"related_works":["https://openalex.org/W1987464952","https://openalex.org/W2735932032","https://openalex.org/W2028169157","https://openalex.org/W2172884470","https://openalex.org/W2188061941","https://openalex.org/W2148077962","https://openalex.org/W2030252680","https://openalex.org/W4253044522","https://openalex.org/W1980950130","https://openalex.org/W1999109251"],"abstract_inverted_index":{"A":[0],"multiple-model":[1,120],"approach":[2],"to":[3,21,35,85,127],"open-loop":[4],"control":[5,33,44,121],"of":[6,14,40,114,140],"T-cell":[7,16,129],"signaling":[8,17],"pathways":[9],"is":[10,97,123],"presented.":[11],"Mathematical":[12],"models":[13,80],"the":[15,23,37,41,67,77,88,105,112,119,137,144,150],"pathway":[18],"are":[19,50,57],"used":[20],"inform":[22],"controller":[24,62],"design.":[25],"The":[26,95,131],"proposed":[27],"framework":[28],"employs":[29],"a":[30],"model":[31,49,106],"predictive":[32],"strategy":[34,108,122],"reduce":[36],"computational":[38],"complexity":[39],"open":[42],"loop":[43],"problem.":[45],"Predictions":[46],"from":[47],"each":[48,61],"weighted":[51],"using":[52],"adaptive":[53],"Akaike":[54],"weights":[55],"that":[56,79],"iteratively":[58],"computed":[59],"for":[60,76],"update":[63],"step":[64],"based":[65],"upon":[66],"most":[68],"relevant":[69],"training":[70],"data":[71],"subsets.":[72],"This":[73],"process":[74],"accounts":[75],"fact":[78],"differ":[81],"in":[82,99,125,149],"their":[83],"ability":[84],"accurately":[86],"reflect":[87],"system":[89],"dynamics":[90],"under":[91],"different":[92],"experimental":[93],"conditions.":[94],"algorithm":[96],"evaluated":[98,124],"silico":[100],"and":[101],"simulations":[102],"demonstrate":[103],"how":[104],"weighting":[107],"more":[109],"effectively":[110],"manages":[111],"inaccuracies":[113],"any":[115],"single":[116],"model.":[117],"Furthermore,":[118],"vitro":[126],"direct":[128],"signaling.":[130],"controller-derived":[132],"input":[133],"sequence":[134],"successfully":[135],"drives":[136],"relative":[138],"concentration":[139],"phosphorylated":[141],"Erk":[142],"along":[143],"desired":[145],"trajectory":[146],"when":[147],"implemented":[148],"laboratory.":[151]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}