{"id":"https://openalex.org/W2079931691","doi":"https://doi.org/10.1109/cdc.2011.6160899","title":"Bifurcation analysis points towards the source of beta neuronal oscillations in Parkinson's disease","display_name":"Bifurcation analysis points towards the source of beta neuronal oscillations in Parkinson's disease","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2079931691","doi":"https://doi.org/10.1109/cdc.2011.6160899","mag":"2079931691"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2011.6160899","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2011.6160899","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Conference on Decision and Control and European Control Conference","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045725813","display_name":"Alejo Nevado\u2010Holgado","orcid":"https://orcid.org/0000-0001-9276-2720"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alejo J Nevado-Holgado","raw_affiliation_strings":["Department of Experimental Psychology, University of Cambridge, Cambridge, UK","Department of Experimental Psychology. University of Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Department of Experimental Psychology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Experimental Psychology. University of Cambridge, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000621191","display_name":"John R. Terry","orcid":"https://orcid.org/0000-0002-6829-5736"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John R. Terry","raw_affiliation_strings":["Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK","Sheffield Institute for Translational Neuroscience, University of Sheffield, UK"],"affiliations":[{"raw_affiliation_string":"Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Sheffield Institute for Translational Neuroscience, University of Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049095056","display_name":"Rafa\u0142 Bogacz","orcid":"https://orcid.org/0000-0002-8994-1661"},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rafal Bogacz","raw_affiliation_strings":["Department of Computer Science, University of Bristol, Bristol, UK","Department of Computer Science,  University of Bristol , UK"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"Department of Computer Science,  University of Bristol , UK","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045725813"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.14309817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"23","issue":null,"first_page":"6492","last_page":"6497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"Substantia nigra","score":0.9095891118049622},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"Basal ganglia","score":0.8281824588775635},{"id":"https://openalex.org/keywords/pars-compacta","display_name":"Pars compacta","score":0.8245314359664917},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7601319551467896},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.6389554142951965},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.6136519908905029},{"id":"https://openalex.org/keywords/dopaminergic","display_name":"Dopaminergic","score":0.5492475032806396},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5457009077072144},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5030404925346375},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.45961329340934753},{"id":"https://openalex.org/keywords/basal-ganglia-disease","display_name":"Basal ganglia disease","score":0.4295230805873871},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.27697426080703735},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.15749311447143555},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.12678071856498718}],"concepts":[{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.9095891118049622},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.8281824588775635},{"id":"https://openalex.org/C2776773494","wikidata":"https://www.wikidata.org/wiki/Q3366041","display_name":"Pars compacta","level":5,"score":0.8245314359664917},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7601319551467896},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6389554142951965},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6136519908905029},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5492475032806396},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5457009077072144},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5030404925346375},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.45961329340934753},{"id":"https://openalex.org/C2780725373","wikidata":"https://www.wikidata.org/wiki/Q4866181","display_name":"Basal ganglia disease","level":4,"score":0.4295230805873871},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27697426080703735},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15749311447143555},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.12678071856498718},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/cdc.2011.6160899","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2011.6160899","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Conference on Decision and Control and European Control Conference","raw_type":"proceedings-article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:f064ea16-0213-481b-954d-882ea1c52164","is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:f064ea16-0213-481b-954d-882ea1c52164","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/86e27f78-c99b-4fdc-961a-ad640cfc4bb6","is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/86e27f78-c99b-4fdc-961a-ad640cfc4bb6","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nevado-Holgado, A J, Terry, J R & Bogacz, R 2011, Bifurcation analysis points towards the source of beta neuronal oscillations in Parkinson's disease. in Proceedings of the IEEE Conference on Decision and Control. https://doi.org/10.1109/CDC.2011.6160899","raw_type":"contributionToPeriodical"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5799999833106995,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321889","display_name":"Fundaci\u00f3n Caja Madrid","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W62603772","https://openalex.org/W641340177","https://openalex.org/W1490680688","https://openalex.org/W1526327880","https://openalex.org/W1605859877","https://openalex.org/W1768450208","https://openalex.org/W1823433896","https://openalex.org/W1832682301","https://openalex.org/W1834763371","https://openalex.org/W1973620174","https://openalex.org/W1973942402","https://openalex.org/W1978178248","https://openalex.org/W1989619740","https://openalex.org/W1990366620","https://openalex.org/W2016696802","https://openalex.org/W2024317187","https://openalex.org/W2024486693","https://openalex.org/W2024849290","https://openalex.org/W2028326234","https://openalex.org/W2032687148","https://openalex.org/W2035177309","https://openalex.org/W2035999685","https://openalex.org/W2041258962","https://openalex.org/W2044486230","https://openalex.org/W2045846109","https://openalex.org/W2060588252","https://openalex.org/W2065147517","https://openalex.org/W2085376923","https://openalex.org/W2087156861","https://openalex.org/W2088495343","https://openalex.org/W2095649828","https://openalex.org/W2113092926","https://openalex.org/W2123745704","https://openalex.org/W2130421880","https://openalex.org/W2140474378","https://openalex.org/W2147041299","https://openalex.org/W2150135821","https://openalex.org/W2160270305","https://openalex.org/W2162826201","https://openalex.org/W2164044007","https://openalex.org/W2164295765","https://openalex.org/W2165731751","https://openalex.org/W2167987951","https://openalex.org/W2171601518","https://openalex.org/W2585198072","https://openalex.org/W4211079924","https://openalex.org/W4297636293"],"related_works":["https://openalex.org/W2178039548","https://openalex.org/W2359931691","https://openalex.org/W3049065873","https://openalex.org/W154169386","https://openalex.org/W4248431072","https://openalex.org/W2884144427","https://openalex.org/W2035149159","https://openalex.org/W2383678931","https://openalex.org/W3216960204","https://openalex.org/W2913997818"],"abstract_inverted_index":{"Parkinson":[0],"disease":[1,24,57,122,148],"is":[2,25,45,58],"the":[3,14,17,29,42,51,56,59,65,76,82,86,107,117,128,151,158,180,185,216,219,233,245],"second":[4],"most":[5,26],"common":[6,27],"neurodegenerative":[7],"disorder":[8],"after":[9],"Alzheimer,":[10],"affecting":[11],"0.16%":[12],"of":[13,61,114,120,146,179,190,221],"population":[15,44],"in":[16,28,38,50,64,96,127,157,165,194,244],"USA":[18],"<sup":[19],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[20],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">1</sup>":[21],".":[22],"This":[23,173],"elderly,":[30],"what":[31],"makes":[32],"it":[33],"a":[34,71,89,176],"prominent":[35,112],"health":[36,195],"problem":[37],"developed":[39],"countries,":[40],"where":[41,210],"elder":[43],"expected":[46],"to":[47,85,124,135],"importantly":[48],"increase":[49],"future.":[52,246],"The":[53],"mechanism":[54],"generating":[55],"death":[60],"dopaminergic":[62],"neurons":[63,80,104],"substantia":[66],"nigra":[67],"pars":[68],"compacta":[69],"(SNc),":[70],"small":[72],"brain":[73,77,93,153,192],"region":[74],"from":[75],"stem.":[78],"These":[79],"release":[81],"neurotransmitter":[83],"dopamine":[84],"basal":[87,108,159,181],"ganglia,":[88,160,182],"large":[90],"and":[91,99,116,139,168,196,202,209],"complex":[92],"structure":[94,193],"implicated":[95],"motor":[97,137],"control":[98],"reinforcement":[100],"learning.":[101],"Once":[102],"SNc":[103],"have":[105],"died,":[106],"ganglia":[109],"starts":[110],"showing":[111],"features":[113],"malfunction,":[115],"characteristics":[118],"symptoms":[119],"Parkinson's":[121,147],"began":[123],"be":[125],"observed":[126,156,164],"patient":[129],"(i.e.":[130],"general":[131],"difficulty":[132],"or":[133,240],"inability":[134],"execute":[136],"movements":[138],"limb":[140],"tremor,":[141],"among":[142],"others).":[143],"Modern":[144],"theory":[145],"focuses":[149],"on":[150,207],"abnormal":[152],"activity":[154,189],"oscillations":[155,212,238],"which":[161,183],"are":[162,213,225],"consistently":[163],"parkinsonian":[166],"patients":[167],"correlate":[169],"with":[170],"their":[171],"symptoms.":[172],"paper":[174],"develops":[175],"mathematical":[177,223],"model":[178,200,224],"reproduces":[184],"experimentally":[186],"recorded":[187],"neuronal":[188],"this":[191,199,222],"disease.":[197],"Studying":[198],"numerical":[201],"analytically,":[203],"we":[204,229],"draw":[205],"conclusion":[206],"how":[208],"these":[211],"generated":[214],"within":[215],"brain.":[217],"If":[218],"conclusions":[220],"further":[226],"confirmed":[227],"experimentally,":[228],"think":[230],"they":[231],"pave":[232],"way":[234],"towards":[235],"controlling":[236],"such":[237],"pharmacologically":[239],"through":[241],"electrode":[242],"stimulation":[243]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
