{"id":"https://openalex.org/W2010346948","doi":"https://doi.org/10.1109/cdc.2011.6160806","title":"Nonlinear MPC of HIV-1 infection with periodic inputs","display_name":"Nonlinear MPC of HIV-1 infection with periodic inputs","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2010346948","doi":"https://doi.org/10.1109/cdc.2011.6160806","mag":"2010346948"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2011.6160806","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2011.6160806","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Conference on Decision and Control and European Control Conference","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023058400","display_name":"Jo\u00e3o Vitor Lemos Pinheiro","orcid":null},"institutions":[{"id":"https://openalex.org/I121345201","display_name":"Instituto de Engenharia de Sistemas e Computadores Investiga\u00e7\u00e3o e Desenvolvimento","ror":"https://ror.org/04mqy3p58","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I121345201","https://openalex.org/I4210125590"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joao V. Pinheiro","raw_affiliation_strings":["INESC-ID, Portugal","Inesc-ID, Portugal#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INESC-ID, Portugal","institution_ids":["https://openalex.org/I121345201"]},{"raw_affiliation_string":"Inesc-ID, Portugal#TAB#","institution_ids":["https://openalex.org/I121345201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089994873","display_name":"Jo\u00e3o M. Lemos","orcid":"https://orcid.org/0000-0003-3149-8035"},"institutions":[{"id":"https://openalex.org/I121345201","display_name":"Instituto de Engenharia de Sistemas e Computadores Investiga\u00e7\u00e3o e Desenvolvimento","ror":"https://ror.org/04mqy3p58","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I121345201","https://openalex.org/I4210125590"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joao M. Lemos","raw_affiliation_strings":["INESC-ID and IST/UTL, R. Alves Redol 9, 1000-029 Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INESC-ID and IST/UTL, R. Alves Redol 9, 1000-029 Lisboa, Portugal","institution_ids":["https://openalex.org/I121345201"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005271169","display_name":"Susana Vinga","orcid":"https://orcid.org/0000-0002-1954-5487"},"institutions":[{"id":"https://openalex.org/I121345201","display_name":"Instituto de Engenharia de Sistemas e Computadores Investiga\u00e7\u00e3o e Desenvolvimento","ror":"https://ror.org/04mqy3p58","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I121345201","https://openalex.org/I4210125590"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Susana Vinga","raw_affiliation_strings":["INESC-ID, Lisboa, Portugal","INESC-ID \u2013 R Alves Redol 9, 1000-029 Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INESC-ID, Lisboa, Portugal","institution_ids":["https://openalex.org/I121345201"]},{"raw_affiliation_string":"INESC-ID \u2013 R Alves Redol 9, 1000-029 Lisboa, Portugal","institution_ids":["https://openalex.org/I121345201"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I121345201"],"apc_list":null,"apc_paid":null,"fwci":2.6815,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.8944168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"65","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/model-predictive-control","display_name":"Model predictive control","score":0.6088243722915649},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5970511436462402},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.5835375785827637},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.55728679895401},{"id":"https://openalex.org/keywords/protease-inhibitor","display_name":"Protease inhibitor (pharmacology)","score":0.4943563938140869},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"Pharmacodynamics","score":0.4691789448261261},{"id":"https://openalex.org/keywords/reverse-transcriptase-inhibitor","display_name":"Reverse-transcriptase inhibitor","score":0.4576207399368286},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.4293118417263031},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.41776224970817566},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.41419315338134766},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.40528738498687744},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.3934765160083771},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.3905675411224365},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3800205588340759},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"Antiretroviral therapy","score":0.3155219554901123},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3019840717315674},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.24955546855926514},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.2492542862892151},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.13994324207305908},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13499537110328674},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09603026509284973}],"concepts":[{"id":"https://openalex.org/C172205157","wikidata":"https://www.wikidata.org/wiki/Q1782962","display_name":"Model predictive control","level":3,"score":0.6088243722915649},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5970511436462402},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.5835375785827637},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.55728679895401},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.4943563938140869},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.4691789448261261},{"id":"https://openalex.org/C2777351918","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Reverse-transcriptase inhibitor","level":5,"score":0.4576207399368286},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.4293118417263031},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.41776224970817566},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.41419315338134766},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40528738498687744},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.3934765160083771},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.3905675411224365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3800205588340759},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.3155219554901123},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3019840717315674},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.24955546855926514},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2492542862892151},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13994324207305908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13499537110328674},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09603026509284973},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc.2011.6160806","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2011.6160806","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Conference on Decision and Control and European Control Conference","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1982488014","https://openalex.org/W2018301734","https://openalex.org/W2044403736","https://openalex.org/W2072821912","https://openalex.org/W2083197317","https://openalex.org/W2083709274","https://openalex.org/W2120117339","https://openalex.org/W2123632233","https://openalex.org/W2132301640","https://openalex.org/W2141802970","https://openalex.org/W2145211831","https://openalex.org/W2145255347","https://openalex.org/W2165572880"],"related_works":["https://openalex.org/W2021628412","https://openalex.org/W2037459512","https://openalex.org/W1979721624","https://openalex.org/W1997671881","https://openalex.org/W2996786515","https://openalex.org/W2017995451","https://openalex.org/W2151420123","https://openalex.org/W1558056931","https://openalex.org/W2159861525","https://openalex.org/W2082701902"],"abstract_inverted_index":{"Although":[0],"many":[1],"papers":[2],"address":[3],"the":[4,16,20,27,30,49,65,72,85,89,120,130,136,151,156,159,209,212,221,236,239],"issue":[5],"of":[6,39,81,118,132,158,165,179,194,211,238],"therapy":[7],"design":[8],"for":[9],"HIV-1":[10,170],"infection":[11,171],"based":[12],"on":[13,109,208],"control":[14,145,166,223],"methods,":[15],"results":[17,160],"available":[18],"in":[19,24,155,168],"literature":[21],"do":[22],"not":[23,34],"general":[25],"consider":[26],"fact":[28],"that":[29,83,191,228],"manipulated":[31,77],"variable":[32,78],"is":[33,113,138,189,226],"continuous":[35],"but":[36],"a":[37,79,124,169],"train":[38,80],"pulses.":[40],"In":[41,61,100],"addition,":[42,101],"they":[43],"are":[44],"usually":[45],"concerned":[46],"only":[47],"with":[48,68,147,162],"relation":[50,67],"between":[51],"drug":[52,98,111,174,240],"effect":[53],"(assumed":[54],"to":[55,63,104,123,135,182,234],"be":[56,205,232],"manipulated)":[57],"and":[58,91,95,106,176,184,199],"virus":[59,110,180,185],"dynamics.":[60,186],"order":[62],"improve":[64],"direct":[66],"actual":[69],"clinical":[70],"practice,":[71],"present":[73],"work":[74],"takes":[75],"as":[76],"impulses":[82],"represent":[84],"pills":[86],"taken":[87],"by":[88,141,216],"patient":[90,102,137],"includes":[92],"pharmacokinetics":[93],"(PK)":[94],"pharmacodynamic":[96],"(PD)":[97],"models.":[99],"adherence":[103],"treatment":[105],"their":[107],"impact":[108],"resistance":[112,181],"also":[114],"modeled.":[115],"The":[116],"problem":[117],"driving":[119],"viral":[121],"load":[122],"low":[125],"specified":[126],"value":[127],"while":[128,219],"minimizing":[129],"amount":[131],"drugs":[133,183,203],"administered":[134],"thus":[139],"addressed":[140],"nonlinear":[142],"model":[143,172],"predictive":[144],"(NMPC)":[146],"periodic":[148,217],"inputs.":[149],"Therefore,":[150],"paper":[152],"contributions":[153],"consist":[154],"characterization":[157],"obtained":[161],"this":[163],"type":[164],"strategy":[167],"comprising":[173],"PK":[175],"PD,":[177],"development":[178],"Furthermore,":[187],"it":[188],"shown":[190],"various":[192],"amounts":[193],"reverse":[195],"transcriptase":[196],"inhibitor":[197,201],"(RTI)":[198],"protease":[200],"(PI)":[202],"can":[204,231],"given":[206],"depending":[207],"weights":[210,230],"cost":[213],"function":[214],"minimized":[215],"NMPC,":[218],"attaining":[220],"same":[222],"objective.":[224],"It":[225],"proposed":[227],"these":[229],"adjusted":[233],"minimize":[235],"toxicity":[237],"cocktail":[241],"administered.":[242]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
