{"id":"https://openalex.org/W1977943697","doi":"https://doi.org/10.1109/cdc.2010.5717982","title":"Oscillation pattern analysis for gene regulatory networks with negative cyclic feedback","display_name":"Oscillation pattern analysis for gene regulatory networks with negative cyclic feedback","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W1977943697","doi":"https://doi.org/10.1109/cdc.2010.5717982","mag":"1977943697"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2010.5717982","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2010.5717982","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"49th IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012594690","display_name":"Yutaka Hori","orcid":"https://orcid.org/0000-0002-3253-4985"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yutaka Hori","raw_affiliation_strings":["Department of Information Physics and Computing, The University of Tokyo, 113-8656, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Information Physics and Computing, The University of Tokyo, 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042960650","display_name":"Shinji Hara","orcid":"https://orcid.org/0000-0002-9539-9426"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Hara","raw_affiliation_strings":["Department of Information Physics and Computing, The University of Tokyo, 113-8656, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Information Physics and Computing, The University of Tokyo, 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012594690"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":0.9252,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.72391556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"5798","last_page":"5803"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9718000292778015,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/harmonic-balance","display_name":"Harmonic balance","score":0.794241189956665},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.7530068159103394},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.6748805046081543},{"id":"https://openalex.org/keywords/oscillation","display_name":"Oscillation (cell signaling)","score":0.6401469707489014},{"id":"https://openalex.org/keywords/frequency-domain","display_name":"Frequency domain","score":0.5880075693130493},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"Negative feedback","score":0.5720738768577576},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.5677395462989807},{"id":"https://openalex.org/keywords/harmonic","display_name":"Harmonic","score":0.4869004786014557},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44591546058654785},{"id":"https://openalex.org/keywords/amplitude","display_name":"Amplitude","score":0.4323018789291382},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.4113519489765167},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3579321503639221},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.34813225269317627},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.312158465385437},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2795255184173584},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20857536792755127},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.20649310946464539},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18323767185211182},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.07956686615943909},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07891187071800232}],"concepts":[{"id":"https://openalex.org/C121758426","wikidata":"https://www.wikidata.org/wiki/Q5659248","display_name":"Harmonic balance","level":3,"score":0.794241189956665},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.7530068159103394},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.6748805046081543},{"id":"https://openalex.org/C2778439541","wikidata":"https://www.wikidata.org/wiki/Q7106412","display_name":"Oscillation (cell signaling)","level":2,"score":0.6401469707489014},{"id":"https://openalex.org/C19118579","wikidata":"https://www.wikidata.org/wiki/Q786423","display_name":"Frequency domain","level":2,"score":0.5880075693130493},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.5720738768577576},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.5677395462989807},{"id":"https://openalex.org/C127934551","wikidata":"https://www.wikidata.org/wiki/Q1148098","display_name":"Harmonic","level":2,"score":0.4869004786014557},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44591546058654785},{"id":"https://openalex.org/C180205008","wikidata":"https://www.wikidata.org/wiki/Q159190","display_name":"Amplitude","level":2,"score":0.4323018789291382},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.4113519489765167},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3579321503639221},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.34813225269317627},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.312158465385437},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2795255184173584},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20857536792755127},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.20649310946464539},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18323767185211182},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.07956686615943909},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07891187071800232},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc.2010.5717982","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2010.5717982","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"49th IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1599969036","https://openalex.org/W1645305843","https://openalex.org/W1971327350","https://openalex.org/W1977943697","https://openalex.org/W1979385177","https://openalex.org/W2003283302","https://openalex.org/W2021022239","https://openalex.org/W2021766626","https://openalex.org/W2034680838","https://openalex.org/W2043471584","https://openalex.org/W2091268473","https://openalex.org/W2134292960","https://openalex.org/W2151265887","https://openalex.org/W2158349487","https://openalex.org/W6680201542"],"related_works":["https://openalex.org/W2071623546","https://openalex.org/W2947985572","https://openalex.org/W2990483082","https://openalex.org/W1777233709","https://openalex.org/W2213387491","https://openalex.org/W2981027764","https://openalex.org/W2092625415","https://openalex.org/W2032559354","https://openalex.org/W2252955868","https://openalex.org/W2130291733"],"abstract_inverted_index":{"Negative":[0],"cyclic":[1,32,119],"feedback":[2],"has":[3],"been":[4],"considered":[5],"to":[6,11,63,117],"be":[7,114],"a":[8],"core":[9],"circuit":[10],"produce":[12],"sustained":[13],"oscillations":[14,29],"in":[15,31,99,106],"gene":[16,33,89,120],"regulatory":[17,34,121],"networks.":[18],"In":[19],"this":[20],"paper,":[21],"we":[22,40],"investigate":[23],"quantitative":[24],"properties":[25],"of":[26,44,58,88,101,126],"the":[27,51,59,80,86],"periodic":[28],"observed":[30],"networks":[35,122],"with":[36,70,132],"negative":[37],"feedback,":[38],"and":[39,47,72,110,136],"provide":[41],"analytic":[42],"estimates":[43,94],"frequency,":[45],"phase":[46],"amplitude.":[48],"We":[49,77],"employ":[50],"harmonic":[52,75,81],"balance":[53,82],"method,":[54],"which":[55],"is":[56],"one":[57],"frequency":[60],"domain":[61],"techniques":[62],"examine":[64],"nonlinear":[65],"oscillatory":[66],"behaviors":[67],"by":[68,84],"approximating":[69],"bias":[71],"first":[73],"order":[74],"components.":[76],"then":[78],"solve":[79],"equations":[83],"utilizing":[85],"structure":[87],"expression":[90],"dynamics.":[91],"The":[92],"presented":[93],"are":[95,130,141],"analytically":[96],"written":[97],"only":[98],"terms":[100],"essential":[102],"biochemical":[103],"parameters":[104],"proposed":[105],"authors'":[107],"previous":[108],"work,":[109],"hence":[111],"they":[112],"can":[113],"easily":[115],"applied":[116],"large-scale":[118],"involving":[123],"any":[124],"number":[125],"genes.":[127],"Our":[128],"results":[129],"demonstrated":[131],"illustrative":[133],"numerical":[134],"examples,":[135],"some":[137],"novel":[138],"biological":[139],"insights":[140],"presented.":[142]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}