{"id":"https://openalex.org/W2161155807","doi":"https://doi.org/10.1109/cdc.2009.5400061","title":"Detection of network structure changes by graphical chain modeling: a case study of hepatitis C virus-related hepatocellular carcinoma","display_name":"Detection of network structure changes by graphical chain modeling: a case study of hepatitis C virus-related hepatocellular carcinoma","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W2161155807","doi":"https://doi.org/10.1109/cdc.2009.5400061","mag":"2161155807"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2009.5400061","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2009.5400061","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 48h IEEE Conference on Decision and Control (CDC) held jointly with 2009 28th Chinese Control Conference","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://kanazawa-u.repo.nii.ac.jp/record/14610/files/ME-PR-KANEKO-S-5624.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007377061","display_name":"Shigeru Saito","orcid":"https://orcid.org/0000-0002-8708-9102"},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Saito","raw_affiliation_strings":["National Institute for Advanced Industrial Science and Technology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Advanced Industrial Science and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014161783","display_name":"Masao Honda","orcid":"https://orcid.org/0000-0003-3050-5854"},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masao Honda","raw_affiliation_strings":["Kanazawa University Graduate School of Medical Science, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanazawa University Graduate School of Medical Science, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069733713","display_name":"Shuichi Kaneko","orcid":"https://orcid.org/0000-0001-7113-3319"},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shu-ichi Kaneko","raw_affiliation_strings":["Kanazawa University Graduate School of Medical Science, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanazawa University Graduate School of Medical Science, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045840721","display_name":"Katsuhisa Horimoto","orcid":"https://orcid.org/0000-0002-8328-6694"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["CN","JP"],"is_corresponding":false,"raw_author_name":"Katsuhisa Horimoto","raw_affiliation_strings":["National Institute for Advanced Industrial Science and Technology, Tokyo, Japan","Shanghai University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Advanced Industrial Science and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I73613424"]},{"raw_affiliation_string":"Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I113940042"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23204965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"5400061","first_page":"5624","last_page":"5630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6532528400421143},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6039655804634094},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4781154990196228},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.45195311307907104},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"Hepatitis C virus","score":0.42581087350845337},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"Tumor progression","score":0.4217411279678345},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.4184611141681671},{"id":"https://openalex.org/keywords/consistency","display_name":"Consistency (knowledge bases)","score":0.41354885697364807},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38776594400405884},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3874526619911194},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.21604415774345398},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19096848368644714},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.13115212321281433}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6532528400421143},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6039655804634094},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4781154990196228},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45195311307907104},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.42581087350845337},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4217411279678345},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.4184611141681671},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.41354885697364807},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38776594400405884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3874526619911194},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.21604415774345398},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19096848368644714},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13115212321281433}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/cdc.2009.5400061","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2009.5400061","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 48h IEEE Conference on Decision and Control (CDC) held jointly with 2009 28th Chinese Control Conference","raw_type":"proceedings-article"},{"id":"pmh:oai:irdb.nii.ac.jp:01288:0000258958","is_oa":true,"landing_page_url":"https://kanazawa-u.repo.nii.ac.jp/records/14610","pdf_url":"https://kanazawa-u.repo.nii.ac.jp/record/14610/files/ME-PR-KANEKO-S-5624.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Proceedings of the IEEE Conference on Decision and Control","raw_type":"conference paper"},{"id":"pmh:oai:kanazawa-u.repo.nii.ac.jp:00014610","is_oa":true,"landing_page_url":"http://hdl.handle.net/2297/24279","pdf_url":null,"source":{"id":"https://openalex.org/S4306400882","display_name":"Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I10091056","host_organization_name":"Kanazawa University","host_organization_lineage":["https://openalex.org/I10091056"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference Paper"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01288:0000258958","is_oa":true,"landing_page_url":"https://kanazawa-u.repo.nii.ac.jp/records/14610","pdf_url":"https://kanazawa-u.repo.nii.ac.jp/record/14610/files/ME-PR-KANEKO-S-5624.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Proceedings of the IEEE Conference on Decision and Control","raw_type":"conference paper"},"sustainable_development_goals":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2161155807.pdf","grobid_xml":"https://content.openalex.org/works/W2161155807.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1494413412","https://openalex.org/W2014466985","https://openalex.org/W2028266503","https://openalex.org/W2039072136","https://openalex.org/W2086945919","https://openalex.org/W2088053309","https://openalex.org/W2096186552","https://openalex.org/W2101861123","https://openalex.org/W2103453943","https://openalex.org/W2127754721","https://openalex.org/W2133392152","https://openalex.org/W2167826316","https://openalex.org/W2468822137","https://openalex.org/W3200009295","https://openalex.org/W4205563404","https://openalex.org/W4230727635","https://openalex.org/W4238253035","https://openalex.org/W4301883765","https://openalex.org/W4302423442","https://openalex.org/W4388323202"],"related_works":["https://openalex.org/W2417822880","https://openalex.org/W2809701302","https://openalex.org/W628600844","https://openalex.org/W1570838273","https://openalex.org/W2410885201","https://openalex.org/W2385390897","https://openalex.org/W3172842848","https://openalex.org/W2418745692","https://openalex.org/W2892191661","https://openalex.org/W2147058584"],"abstract_inverted_index":{"One":[0],"of":[1,6,28,39,80,84,94,115,138,148,158,173],"the":[2,12,19,36,51,57,63,72,77,91,97,105,113,120,125,135,155,159,171,178,183,191,197,206,211,218,222],"most":[3],"characteristic":[4],"features":[5],"biological":[7],"molecular":[8],"networks":[9],"is":[10,200],"that":[11],"network":[13,37,52,121,207],"structure":[14,53,208],"itself":[15],"changes,":[16,122],"depending":[17],"on":[18],"cellular":[20],"environment.":[21],"Indeed,":[22],"activated":[23],"molecules":[24,41],"show":[25],"a":[26,81,153,201],"variety":[27],"responses":[29],"to":[30,49,76,89,104,111,134,204,216],"distinctive":[31,146],"cell":[32,179,212],"conditions,":[33],"and":[34,108,182,215],"subsequently":[35],"structures":[38],"active":[40],"also":[42],"change.":[43],"Here":[44],"we":[45],"present":[46,198],"an":[47],"approach":[48],"trace":[50],"changes":[54,209],"by":[55,123],"using":[56,124],"graphical":[58,73],"chain":[59,74,98,156],"model":[60,75,99,157,205],"developed":[61],"from":[62],"gene":[64,161,219],"expression":[65,78,136],"data.":[66],"The":[67,129],"previous":[68],"procedure":[69,131,199],"for":[70,119,221],"applying":[71],"profiles":[79,137],"limited":[82],"number":[83],"genes":[85,189],"has":[86,100],"been":[87,101],"improved":[88,130],"analyze":[90],"entire":[92],"set":[93],"genes.":[95],"Furthermore,":[96],"rearranged":[102],"according":[103],"association":[106],"strength,":[107],"was":[109,132,167,175],"scrutinized":[110],"identify":[112],"candidates":[114,220],"essential":[116],"gene-gene":[117,184],"relationships":[118,163,185],"path":[126],"consistency":[127],"algorithm.":[128],"applied":[133],"8,427":[139],"genes,":[140],"which":[141,170],"were":[142,193],"measured":[143],"in":[144,169,177,210],"two":[145],"stages":[147],"liver":[149],"cancer":[150],"progression.":[151,223],"As":[152],"result,":[154],"18":[160],"cluster":[162],"with":[164],"strong":[165],"associations":[166],"inferred,":[168],"coordination":[172],"clusters":[174],"described":[176],"stage":[180,213],"progression,":[181,214],"between":[186],"known":[187],"cancer-related":[188],"causing":[190],"progression":[192],"further":[194],"refined.":[195],"Thus,":[196],"useful":[202],"method":[203],"clarify":[217]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
