{"id":"https://openalex.org/W2122167908","doi":"https://doi.org/10.1109/cdc.2008.4738854","title":"Estimation of immune states in HIV dynamics","display_name":"Estimation of immune states in HIV dynamics","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2122167908","doi":"https://doi.org/10.1109/cdc.2008.4738854","mag":"2122167908"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2008.4738854","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2008.4738854","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 47th IEEE Conference on Decision and Control","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102909707","display_name":"Hyuk\u2010Jun Chang","orcid":"https://orcid.org/0000-0001-7781-2961"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"H. Chang","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, Imperial College London, London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018225150","display_name":"Alessandro Astolfi","orcid":"https://orcid.org/0000-0002-4331-454X"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"A. Astolfi","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, Imperial College London, London, UK","Dipartimento di Informatica, Sistemi e Produzione, Universit\u00e0 di Roma Tor Vergata, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Dipartimento di Informatica, Sistemi e Produzione, Universit\u00e0 di Roma Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102909707"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":0.4984,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59858219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"28","issue":null,"first_page":"1759","last_page":"1764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.9850000143051147,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.688054084777832},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.6094492673873901},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.5864319801330566},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5641003251075745},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.5236901044845581},{"id":"https://openalex.org/keywords/observer","display_name":"Observer (physics)","score":0.5044959783554077},{"id":"https://openalex.org/keywords/system-dynamics","display_name":"System dynamics","score":0.41666799783706665},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.364425390958786},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.29603976011276245},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.2579212784767151},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2423134744167328},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22020277380943298},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.21163424849510193},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.0780242383480072}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.688054084777832},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.6094492673873901},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5864319801330566},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5641003251075745},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.5236901044845581},{"id":"https://openalex.org/C2780704645","wikidata":"https://www.wikidata.org/wiki/Q9251458","display_name":"Observer (physics)","level":2,"score":0.5044959783554077},{"id":"https://openalex.org/C77405623","wikidata":"https://www.wikidata.org/wiki/Q598451","display_name":"System dynamics","level":2,"score":0.41666799783706665},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.364425390958786},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29603976011276245},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.2579212784767151},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2423134744167328},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22020277380943298},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.21163424849510193},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0780242383480072},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc.2008.4738854","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2008.4738854","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 47th IEEE Conference on Decision and Control","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1640996800","https://openalex.org/W1959404578","https://openalex.org/W1969133711","https://openalex.org/W2018301734","https://openalex.org/W2022098233","https://openalex.org/W2046313164","https://openalex.org/W2065757233","https://openalex.org/W2071085880","https://openalex.org/W2072821912","https://openalex.org/W2093259226","https://openalex.org/W2118987298","https://openalex.org/W2121733155","https://openalex.org/W2143148297"],"related_works":["https://openalex.org/W3192036299","https://openalex.org/W2146428417","https://openalex.org/W2357948923","https://openalex.org/W3176458675","https://openalex.org/W4313472242","https://openalex.org/W2332159055","https://openalex.org/W2030500189","https://openalex.org/W2419188526","https://openalex.org/W2144422987","https://openalex.org/W2018938924"],"abstract_inverted_index":{"The":[0,44],"human":[1],"immunodeficiency":[2],"virus":[3],"infection,":[4],"that":[5,15,66],"causes":[6],"acquired":[7,73],"immune":[8,34,74,89],"deficiency":[9,75],"syndrome,":[10],"is":[11,47,103,109],"a":[12],"dynamic":[13],"process":[14],"can":[16],"be":[17],"modeled":[18],"via":[19],"differential":[20],"equations.":[21],"In":[22,77],"the":[23,33,50,70,85,88,93,97,118,121],"literature":[24],"of":[25,38,72,87,96,120],"control":[26,29,45],"applications,":[27],"model-based":[28],"methods":[30,82],"to":[31,48,52,62,83,116],"boost":[32],"system":[35,51,90],"by":[36],"means":[37],"drug":[39],"scheduling":[40],"have":[41],"been":[42],"reported.":[43],"purpose":[46],"steer":[49],"an":[53,63,106],"equilibrium":[54],"condition,":[55],"known":[56],"as":[57],"long-term":[58],"nonprogressor,":[59],"which":[60],"corresponds":[61],"infected":[64],"patient":[65],"does":[67],"not":[68],"develop":[69],"symptoms":[71],"syndrome.":[76],"this":[78],"paper":[79],"we":[80],"investigate":[81],"estimate":[84],"state":[86],"based":[91],"on":[92],"available":[94],"outputs":[95],"HIV":[98],"model.":[99],"A":[100],"nonlinear":[101],"observer":[102,108],"designed":[104],"and":[105],"approximate":[107],"also":[110],"given.":[111],"Computer":[112],"simulations":[113],"are":[114],"presented":[115],"show":[117],"feasibility":[119],"estimation":[122],"methodology.":[123]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}