{"id":"https://openalex.org/W2167530676","doi":"https://doi.org/10.1109/cdc.2004.1428694","title":"Optimal control in a model of dendritic cell transfection cancer immunotherapy","display_name":"Optimal control in a model of dendritic cell transfection cancer immunotherapy","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2167530676","doi":"https://doi.org/10.1109/cdc.2004.1428694","mag":"2167530676"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2004.1428694","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2004.1428694","pdf_url":null,"source":{"id":"https://openalex.org/S4363608267","display_name":"2004 43rd IEEE Conference on Decision and Control (CDC) (IEEE Cat. No.04CH37601)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2004 43rd IEEE Conference on Decision and Control (CDC) (IEEE Cat. No.04CH37601)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010454141","display_name":"Filippo Castiglione","orcid":"https://orcid.org/0000-0002-1442-3552"},"institutions":[{"id":"https://openalex.org/I4210106125","display_name":"Istituto per le Applicazioni del Calcolo Mauro Picone","ror":"https://ror.org/00ygy3d85","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106125","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Castiglione","raw_affiliation_strings":["Consiglio Nazionale delle Ricerche (CNR), Istituto Applicazioni del Calcolo (IAC) M. Picone, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consiglio Nazionale delle Ricerche (CNR), Istituto Applicazioni del Calcolo (IAC) M. Picone, Rome, Italy","institution_ids":["https://openalex.org/I4210106125"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057629608","display_name":"Benedetto Piccoli","orcid":"https://orcid.org/0000-0002-6000-5394"},"institutions":[{"id":"https://openalex.org/I4210106125","display_name":"Istituto per le Applicazioni del Calcolo Mauro Picone","ror":"https://ror.org/00ygy3d85","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106125","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"B. Piccoli","raw_affiliation_strings":["Consiglio Nazionale delle Ricerche (CNR), Istituto Applicazioni del Calcolo (IAC) M. Picone, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consiglio Nazionale delle Ricerche (CNR), Istituto Applicazioni del Calcolo (IAC) M. Picone, Rome, Italy","institution_ids":["https://openalex.org/I4210106125"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210106125"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"60","issue":null,"first_page":"585","last_page":"590 Vol.1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12391","display_name":"Artificial Immune Systems Applications","score":0.9886999726295471,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.5895499587059021},{"id":"https://openalex.org/keywords/optimal-control","display_name":"Optimal control","score":0.5728179812431335},{"id":"https://openalex.org/keywords/schedule","display_name":"Schedule","score":0.5724272727966309},{"id":"https://openalex.org/keywords/dendritic-cell","display_name":"Dendritic cell","score":0.5536556243896484},{"id":"https://openalex.org/keywords/transfection","display_name":"Transfection","score":0.5497817993164062},{"id":"https://openalex.org/keywords/competition","display_name":"Competition (biology)","score":0.5108141899108887},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5039035677909851},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46408364176750183},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.44987690448760986},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2847764194011688},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.259152352809906},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.23607873916625977},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.21978771686553955},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17598599195480347},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.16460326313972473},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.0633787214756012}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5895499587059021},{"id":"https://openalex.org/C91575142","wikidata":"https://www.wikidata.org/wiki/Q1971426","display_name":"Optimal control","level":2,"score":0.5728179812431335},{"id":"https://openalex.org/C68387754","wikidata":"https://www.wikidata.org/wiki/Q7271585","display_name":"Schedule","level":2,"score":0.5724272727966309},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5536556243896484},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5497817993164062},{"id":"https://openalex.org/C91306197","wikidata":"https://www.wikidata.org/wiki/Q45767","display_name":"Competition (biology)","level":2,"score":0.5108141899108887},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5039035677909851},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46408364176750183},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44987690448760986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2847764194011688},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.259152352809906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23607873916625977},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.21978771686553955},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17598599195480347},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.16460326313972473},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0633787214756012},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc.2004.1428694","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2004.1428694","pdf_url":null,"source":{"id":"https://openalex.org/S4363608267","display_name":"2004 43rd IEEE Conference on Decision and Control (CDC) (IEEE Cat. No.04CH37601)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2004 43rd IEEE Conference on Decision and Control (CDC) (IEEE Cat. No.04CH37601)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6899999976158142}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1491720975","https://openalex.org/W1528856837","https://openalex.org/W1582706191","https://openalex.org/W1587799944","https://openalex.org/W1834154263","https://openalex.org/W1971201122","https://openalex.org/W2040837794","https://openalex.org/W2049723320","https://openalex.org/W2118590834","https://openalex.org/W2334591577","https://openalex.org/W4296154082","https://openalex.org/W6638718600"],"related_works":["https://openalex.org/W2372521113","https://openalex.org/W2978251436","https://openalex.org/W1980609410","https://openalex.org/W2361321344","https://openalex.org/W2136925073","https://openalex.org/W137690307","https://openalex.org/W2073671804","https://openalex.org/W110876028","https://openalex.org/W2023907037","https://openalex.org/W2372050649"],"abstract_inverted_index":{"We":[0],"build":[1],"a":[2,14],"population":[3],"dynamics":[4],"model":[5],"of":[6,23,31,33],"the":[7,21,28],"competition":[8],"among":[9],"immune":[10],"system":[11],"cells":[12,36],"and":[13],"generic":[15],"tumor":[16],"cells.":[17],"Then,":[18],"we":[19],"apply":[20],"theory":[22],"optimal":[24,29],"control":[25],"to":[26],"find":[27],"schedule":[30],"injection":[32],"autologous":[34],"dendritic":[35],"used":[37],"as":[38],"immunotherapeutic":[39],"agent.":[40]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
