{"id":"https://openalex.org/W2763693830","doi":"https://doi.org/10.1109/ccta.2017.8062584","title":"Utilizing biomarkers to forecast quantitative metabolite concentration profiles in human red blood cells","display_name":"Utilizing biomarkers to forecast quantitative metabolite concentration profiles in human red blood cells","publication_year":2017,"publication_date":"2017-08-01","ids":{"openalex":"https://openalex.org/W2763693830","doi":"https://doi.org/10.1109/ccta.2017.8062584","mag":"2763693830"},"language":"en","primary_location":{"id":"doi:10.1109/ccta.2017.8062584","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ccta.2017.8062584","pdf_url":null,"source":{"id":"https://openalex.org/S4306498159","display_name":"2017 IEEE Conference on Control Technology and Applications (CCTA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE Conference on Control Technology and Applications (CCTA)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082126398","display_name":"James T. Yurkovich","orcid":"https://orcid.org/0000-0002-9403-509X"},"institutions":[{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]},{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James T. Yurkovich","raw_affiliation_strings":["Bioinformatics and Systems Biology Program, University of California, San Diezo. La Jolla, CA, USA","Department of Bioengineering, University of California, San Diego La Jolla, CA, USA"],"affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, University of California, San Diezo. La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego La Jolla, CA, USA","institution_ids":["https://openalex.org/I4210133661","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080751595","display_name":"Laurence Yang","orcid":"https://orcid.org/0000-0001-6663-7643"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurence Yang","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego La Jolla, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego La Jolla, CA, USA","institution_ids":["https://openalex.org/I4210133661","https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051097609","display_name":"Bernhard \u00d8. Palsson","orcid":"https://orcid.org/0000-0003-2357-6785"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernhard O. Palsson","raw_affiliation_strings":["Bioinformatics and Systems Biology Program, University of California, San Diezo. La Jolla, CA, USA","Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA"],"affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, University of California, San Diezo. La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082126398"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210133661"],"apc_list":null,"apc_paid":null,"fwci":3.1522,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.89516129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2008","issue":null,"first_page":"961","last_page":"966"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9699000120162964,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9377999901771545,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.6736732125282288},{"id":"https://openalex.org/keywords/red-blood-cell","display_name":"Red blood cell","score":0.4152202308177948},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38958826661109924},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.31534525752067566},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1202867329120636}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6736732125282288},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.4152202308177948},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38958826661109924},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31534525752067566},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1202867329120636}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ccta.2017.8062584","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ccta.2017.8062584","pdf_url":null,"source":{"id":"https://openalex.org/S4306498159","display_name":"2017 IEEE Conference on Control Technology and Applications (CCTA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE Conference on Control Technology and Applications (CCTA)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6600000262260437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W178056938","https://openalex.org/W1588334255","https://openalex.org/W1661767063","https://openalex.org/W1946741439","https://openalex.org/W1957278093","https://openalex.org/W1965324089","https://openalex.org/W1997062226","https://openalex.org/W2016210396","https://openalex.org/W2036689171","https://openalex.org/W2058730913","https://openalex.org/W2060748779","https://openalex.org/W2132022337","https://openalex.org/W2150010190","https://openalex.org/W2161289889","https://openalex.org/W2194318288","https://openalex.org/W2235759113","https://openalex.org/W2236368193","https://openalex.org/W2470147723","https://openalex.org/W2495368724","https://openalex.org/W2507939969","https://openalex.org/W2513955315","https://openalex.org/W2560481629","https://openalex.org/W2592379136"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487","https://openalex.org/W1986764834"],"abstract_inverted_index":{"One":[0],"of":[1,9,15,29,42,59,72,95,112,125,132,152,162,175,182,198],"the":[2,13,16,40,43,69,93,99,110,133,138,178,195],"major":[3],"limitations":[4],"in":[5,53,98,137,189],"making":[6],"experimental":[7],"measurements":[8,30,176],"biological":[10],"systems":[11],"is":[12],"complexity":[14],"network":[17,100,143],"being":[18],"investigated.":[19],"Major":[20],"efforts":[21],"have":[22,62],"been":[23,63],"made":[24],"to":[25,36,86,121,166,193],"identify":[26],"a":[27,54,57,88,102,117,158,173,190],"subset":[28,174],"(\u201cbiomarkers\u201d)":[31],"that":[32,65,79,90,130],"can":[33,66,145],"be":[34,84,146],"used":[35,85],"provide":[37],"information":[38],"about":[39],"rest":[41],"system.":[44],"For":[45],"red":[46,139],"blood":[47,55,140],"cells":[48],"under":[49],"cold":[50],"storage":[51,153,183],"conditions":[52],"bank,":[56],"set":[58],"metabolite":[60,168],"biomarkers":[61,81],"identified":[64],"reliably":[67],"define":[68],"qualitative":[70],"trend":[71],"cellular":[73],"metabolism.":[74],"Recently,":[75],"it":[76],"was":[77],"shown":[78],"these":[80,113,126,185],"could":[82],"also":[83],"train":[87],"model":[89,120],"quantitatively":[91],"predicts":[92],"concentrations":[94],"other":[96],"metabolites":[97,135],"over":[101],"45":[103],"day":[104],"time":[105,155],"course.":[106],"Here,":[107],"we":[108],"extend":[109],"utility":[111],"methods":[114,186],"by":[115,170],"using":[116],"linear":[118],"blackbox":[119],"forecast":[122,167],"future":[123],"values":[124],"concentrations.":[127],"We":[128],"show":[129],"57":[131],"70":[134],"measured":[136],"cell":[141],"metabolic":[142,196],"(81%)":[144],"accurately":[147],"forecasted":[148],"after":[149],"8":[150],"days":[151,181],"(5":[154],"points)":[156],"with":[157],"global":[159],"median":[160],"error":[161],"18.36%.":[163],"The":[164],"ability":[165],"profiles":[169],"only":[171],"requiring":[172],"for":[177],"first":[179],"few":[180],"makes":[184],"immediately":[187],"applicable":[188],"clinical":[191],"setting":[192],"assess":[194],"health":[197],"stored":[199],"blood.":[200]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}