{"id":"https://openalex.org/W2011255641","doi":"https://doi.org/10.1109/ccece.2012.6334866","title":"Intensity integrated Laplacian algorithm for human metaphase chromosome centromere detection","display_name":"Intensity integrated Laplacian algorithm for human metaphase chromosome centromere detection","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2011255641","doi":"https://doi.org/10.1109/ccece.2012.6334866","mag":"2011255641"},"language":"en","primary_location":{"id":"doi:10.1109/ccece.2012.6334866","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ccece.2012.6334866","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 25th IEEE Canadian Conference on Electrical and Computer Engineering (CCECE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047011933","display_name":"A. S. Arachchige","orcid":null},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A. S. Arachchige","raw_affiliation_strings":["Image Recognition & Intelligent Systems Laboratory, University of Western Ontario, ON, Canada","Image Recognition & Intelligent Systems Laboratory, University of Western Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Image Recognition & Intelligent Systems Laboratory, University of Western Ontario, ON, Canada","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"Image Recognition & Intelligent Systems Laboratory, University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049647213","display_name":"Jagath Samarabandu","orcid":"https://orcid.org/0009-0006-5871-6548"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Samarabandu","raw_affiliation_strings":["Image Recognition & Intelligent Systems Laboratory, University of Western Ontario, ON, Canada","Image Recognition & Intelligent Systems Laboratory, University of Western Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Image Recognition & Intelligent Systems Laboratory, University of Western Ontario, ON, Canada","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"Image Recognition & Intelligent Systems Laboratory, University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010680275","display_name":"Peter K. Rogan","orcid":"https://orcid.org/0000-0003-2070-5254"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"P. K. Rogan","raw_affiliation_strings":["Departments of Biochemistry, Schulich School of Medicine & Dentistry, University of Western Ontario, ON, Canada","Department of Biochemistry, Schulich School of Medicine & Dentistry, University of Western Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry, Schulich School of Medicine & Dentistry, University of Western Ontario, ON, Canada","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"Department of Biochemistry, Schulich School of Medicine & Dentistry, University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014952448","display_name":"Joan H.M. Knoll","orcid":"https://orcid.org/0000-0001-6691-1710"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. H. M. Knoll","raw_affiliation_strings":["Departments of Pathology, Schulich School of Medicine & Dentistry, University of Western Ontario, ON, Canada","Department of Pathology, Schulich School of Medicine & Dentistry, University of Western Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Schulich School of Medicine & Dentistry, University of Western Ontario, ON, Canada","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"Department of Pathology, Schulich School of Medicine & Dentistry, University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I125749732"],"apc_list":null,"apc_paid":null,"fwci":0.4089,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68064668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"89","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centromere","display_name":"Centromere","score":0.8276081085205078},{"id":"https://openalex.org/keywords/metaphase","display_name":"Metaphase","score":0.742020845413208},{"id":"https://openalex.org/keywords/chromosome","display_name":"Chromosome","score":0.5397272109985352},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47250521183013916},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4603848457336426},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.38906770944595337},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26434022188186646},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.25225830078125},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14385974407196045}],"concepts":[{"id":"https://openalex.org/C63491729","wikidata":"https://www.wikidata.org/wiki/Q14762596","display_name":"Centromere","level":4,"score":0.8276081085205078},{"id":"https://openalex.org/C70278784","wikidata":"https://www.wikidata.org/wiki/Q574427","display_name":"Metaphase","level":4,"score":0.742020845413208},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5397272109985352},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47250521183013916},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4603848457336426},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.38906770944595337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26434022188186646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25225830078125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14385974407196045}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ccece.2012.6334866","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ccece.2012.6334866","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 25th IEEE Canadian Conference on Electrical and Computer Engineering (CCECE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1527930907","https://openalex.org/W2008421775","https://openalex.org/W2056450868","https://openalex.org/W2064327730","https://openalex.org/W2079423563","https://openalex.org/W2081981415","https://openalex.org/W2104093257","https://openalex.org/W2120444674","https://openalex.org/W2142417295","https://openalex.org/W2145803225","https://openalex.org/W2159450535","https://openalex.org/W6631573577","https://openalex.org/W6681640588"],"related_works":["https://openalex.org/W4387492829","https://openalex.org/W1975241813","https://openalex.org/W4231601583","https://openalex.org/W4386219590","https://openalex.org/W2094119374","https://openalex.org/W1908751848","https://openalex.org/W2154418599","https://openalex.org/W2100452179","https://openalex.org/W2383208855","https://openalex.org/W2019424438"],"abstract_inverted_index":{"Centromere":[0],"localization":[1],"in":[2,10,34,46,52],"human":[3,119],"metaphase":[4,47,120],"chromosomes":[5,48],"is":[6,89],"an":[7],"essential":[8],"task":[9],"many":[11],"cytogenetic":[12],"diagnosis":[13],"procedures.":[14],"The":[15,81,99],"centromere":[16,79],"location":[17],"can":[18],"be":[19,105],"utilized":[20],"to":[21,41,74,104,109],"derive":[22],"information":[23,68,73,83],"such":[24],"as":[25,69,71],"the":[26,53,85,110,113],"chromosome":[27],"type,":[28],"polarity":[29],"assignment":[30],"etc.":[31],"Methods":[32],"available":[33],"literature":[35],"yield":[36],"unreliable":[37],"results":[38],"mainly":[39],"due":[40],"high":[42],"variability":[43],"of":[44,87,112],"morphology":[45],"and":[49],"boundary":[50],"noise":[51],"image.":[54],"In":[55],"this":[56],"paper":[57],"we":[58],"have":[59],"proposed":[60,100],"a":[61,76,92],"multi-staged":[62],"algorithm":[63],"which":[64],"utilizes":[65],"both":[66],"contour":[67],"well":[70],"intensity":[72],"obtain":[75],"more":[77,106],"accurate":[78,107],"location.":[80],"width":[82],"along":[84],"axis":[86],"symmetry":[88],"obtained":[90],"using":[91],"novel":[93],"Laplacian":[94],"based":[95],"thickness":[96],"measurement":[97],"algorithm.":[98],"method":[101],"was":[102],"observed":[103],"compared":[108],"state":[111],"art":[114],"when":[115],"tested":[116],"with":[117],"226":[118],"chromosomes.":[121]},"counts_by_year":[{"year":2017,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}
