{"id":"https://openalex.org/W2527922775","doi":"https://doi.org/10.1109/cca.2016.7587868","title":"Modellig of adrenaline counterregulatory action during hypoglycaemia in Type 1 Diabetes","display_name":"Modellig of adrenaline counterregulatory action during hypoglycaemia in Type 1 Diabetes","publication_year":2016,"publication_date":"2016-09-01","ids":{"openalex":"https://openalex.org/W2527922775","doi":"https://doi.org/10.1109/cca.2016.7587868","mag":"2527922775"},"language":"en","primary_location":{"id":"doi:10.1109/cca.2016.7587868","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cca.2016.7587868","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE Conference on Control Applications (CCA)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082925909","display_name":"Vanessa Moscard\u00f3","orcid":"https://orcid.org/0000-0002-0149-4669"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"V. Moscardo","raw_affiliation_strings":["Universitat Polit\u00e8cnica de Val\u00e8ncia, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Universitat Polit\u00e8cnica de Val\u00e8ncia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042170720","display_name":"Paolo Rossetti","orcid":"https://orcid.org/0000-0002-2767-2996"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Rossetti","raw_affiliation_strings":["Hospital Francesc de Borja de Gandia, Gandia, Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Francesc de Borja de Gandia, Gandia, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018064279","display_name":"Francisco Javier Ampudia\u2010Blasco","orcid":"https://orcid.org/0000-0003-0221-0901"},"institutions":[{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"F. J. Ampudia-Blasco","raw_affiliation_strings":["Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I4210094406"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041769374","display_name":"Jorge Bond\u00eda","orcid":"https://orcid.org/0000-0001-7286-3719"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Bondia","raw_affiliation_strings":["Universitat Polit\u00e8cnica de Val\u00e8ncia, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Universitat Polit\u00e8cnica de Val\u00e8ncia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082925909"],"corresponding_institution_ids":["https://openalex.org/I60053951"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.14545628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"430","last_page":"435"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.7383294701576233},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.7292925715446472},{"id":"https://openalex.org/keywords/glucagon","display_name":"Glucagon","score":0.6478027701377869},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"Hypoglycemia","score":0.6301016211509705},{"id":"https://openalex.org/keywords/epinephrine","display_name":"Epinephrine","score":0.5868202447891235},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5724574327468872},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"Type 1 diabetes","score":0.5071613788604736},{"id":"https://openalex.org/keywords/glucose-clamp-technique","display_name":"Glucose clamp technique","score":0.42831140756607056},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"Type 2 diabetes","score":0.4214799702167511},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.37433651089668274},{"id":"https://openalex.org/keywords/hormone","display_name":"Hormone","score":0.37385374307632446},{"id":"https://openalex.org/keywords/pancreatic-hormone","display_name":"Pancreatic hormone","score":0.18246379494667053},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"Insulin resistance","score":0.07902425527572632}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7383294701576233},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7292925715446472},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.6478027701377869},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.6301016211509705},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.5868202447891235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5724574327468872},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.5071613788604736},{"id":"https://openalex.org/C2778808658","wikidata":"https://www.wikidata.org/wiki/Q2975183","display_name":"Glucose clamp technique","level":5,"score":0.42831140756607056},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4214799702167511},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.37433651089668274},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.37385374307632446},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.18246379494667053},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.07902425527572632}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cca.2016.7587868","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cca.2016.7587868","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE Conference on Control Applications (CCA)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7699999809265137,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W102487131","https://openalex.org/W1503296932","https://openalex.org/W1931223844","https://openalex.org/W1972564143","https://openalex.org/W2046087928","https://openalex.org/W2057289772","https://openalex.org/W2072878208","https://openalex.org/W2087707740","https://openalex.org/W2099166298","https://openalex.org/W2107353084","https://openalex.org/W2124282046","https://openalex.org/W2129995532","https://openalex.org/W2156353972","https://openalex.org/W2208680748","https://openalex.org/W2332531077","https://openalex.org/W2336687883","https://openalex.org/W4254695749"],"related_works":["https://openalex.org/W2461016652","https://openalex.org/W2413441242","https://openalex.org/W2105076958","https://openalex.org/W1975173480","https://openalex.org/W1980776913","https://openalex.org/W3204188315","https://openalex.org/W2057731893","https://openalex.org/W2150152554","https://openalex.org/W2033789657","https://openalex.org/W2007626235"],"abstract_inverted_index":{"The":[0,83],"risk":[1],"of":[2,42,53,74,77,99,102,119,127,135],"hypoglycaemia":[3,47],"is":[4,38,70],"still":[5],"a":[6,24,57,113],"limiting":[7],"factor":[8],"for":[9],"achieving":[10],"near-normoglycaemia":[11],"in":[12,27,104,123,138],"subjects":[13],"with":[14],"Type":[15,34],"1":[16,35],"Diabetes.":[17],"From":[18],"the":[19,39,50,78,97,133],"metabolic":[20],"perspective,":[21],"counterregulation":[22,137],"has":[23],"significant":[25],"influence":[26,98],"plasma":[28,128],"glucose":[29,103,129],"concentration":[30,91],"during":[31],"hypoglycaemia.":[32],"In":[33,56],"Diabetes,":[36],"adrenaline":[37,61,67,90],"first":[40],"line":[41],"counterregulatory":[43,68,93],"hormone":[44],"response":[45,94],"to":[46,49],"due":[48],"early":[51],"impairment":[52],"glucagon":[54],"secretion.":[55],"previous":[58],"work,":[59],"an":[60,75],"secretion":[62],"model":[63],"was":[64],"developed.":[65],"Here,":[66],"action":[69],"addressed":[71],"by":[72,117],"means":[73,118],"extension":[76],"well-known":[79],"Bergman":[80],"Minimal":[81],"Model.":[82],"added":[84],"terms":[85],"were":[86,108],"based":[87],"on":[88],"both":[89],"after":[92],"begins":[95],"and":[96],"hypoglycaemic":[100,142],"levels":[101],"blood.":[105],"Individual":[106],"parameters":[107],"estimated":[109],"using":[110],"data":[111],"from":[112],"eu-hypoglycaemic":[114],"clamp":[115],"study":[116],"global":[120],"optimization":[121],"algorithms,":[122],"particular":[124],"CMA-ES.":[125],"Analysis":[126],"prediction":[130],"accuracy":[131],"demonstrated":[132],"importance":[134],"considering":[136],"predictive":[139],"algorithms":[140],"when":[141],"events":[143],"occur.":[144]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}