{"id":"https://openalex.org/W2049589633","doi":"https://doi.org/10.1109/cca.2013.6662769","title":"A two-compartment fractional derivative model for Propofol diffusion in anesthesia","display_name":"A two-compartment fractional derivative model for Propofol diffusion in anesthesia","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W2049589633","doi":"https://doi.org/10.1109/cca.2013.6662769","mag":"2049589633"},"language":"en","primary_location":{"id":"doi:10.1109/cca.2013.6662769","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cca.2013.6662769","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Conference on Control Applications (CCA)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073964670","display_name":"Dana Copo\u0163","orcid":"https://orcid.org/0000-0002-6010-830X"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Dana Copot","raw_affiliation_strings":["Department of Electrical Energy, Systems and Automation, Ghent University, Gent, Belgium","Dept. of Electr. Energy, Syst. & Autom., Ghent Univ., Ghent, Belgium"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Energy, Systems and Automation, Ghent University, Gent, Belgium","institution_ids":["https://openalex.org/I32597200"]},{"raw_affiliation_string":"Dept. of Electr. Energy, Syst. & Autom., Ghent Univ., Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017249714","display_name":"Am\u00e9lie Chevalier","orcid":"https://orcid.org/0000-0002-2941-1538"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Amelie Chevalier","raw_affiliation_strings":["Department of Electrical Energy, Systems and Automation, Ghent University, Gent, Belgium","Dept. of Electr. Energy, Syst. & Autom., Ghent Univ., Ghent, Belgium"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Energy, Systems and Automation, Ghent University, Gent, Belgium","institution_ids":["https://openalex.org/I32597200"]},{"raw_affiliation_string":"Dept. of Electr. Energy, Syst. & Autom., Ghent Univ., Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004573956","display_name":"Clara M. Ionescu","orcid":"https://orcid.org/0000-0001-7685-035X"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Clara M. Ionescu","raw_affiliation_strings":["Department of Electrical Energy, Systems and Automation, Ghent University, Gent, Belgium","Dept. of Electr. Energy, Syst. & Autom., Ghent Univ., Ghent, Belgium"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Energy, Systems and Automation, Ghent University, Gent, Belgium","institution_ids":["https://openalex.org/I32597200"]},{"raw_affiliation_string":"Dept. of Electr. Energy, Syst. & Autom., Ghent Univ., Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013255393","display_name":"Robin De Keyser","orcid":null},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Robin De Keyser","raw_affiliation_strings":["Department of Electrical Energy, Systems and Automation, Ghent University, Gent, Belgium","Dept. of Electr. Energy, Syst. & Autom., Ghent Univ., Ghent, Belgium"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Energy, Systems and Automation, Ghent University, Gent, Belgium","institution_ids":["https://openalex.org/I32597200"]},{"raw_affiliation_string":"Dept. of Electr. Energy, Syst. & Autom., Ghent Univ., Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5073964670"],"corresponding_institution_ids":["https://openalex.org/I32597200"],"apc_list":null,"apc_paid":null,"fwci":1.9652,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.85641749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"264","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10288","display_name":"Fractional Differential Equations Solutions","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11081","display_name":"Advanced Control Systems Design","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"Propofol","score":0.9021593332290649},{"id":"https://openalex.org/keywords/fractional-calculus","display_name":"Fractional calculus","score":0.7435191869735718},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.6097592711448669},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.5653596520423889},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.5225883722305298},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"Pharmacodynamics","score":0.5104910135269165},{"id":"https://openalex.org/keywords/derivative","display_name":"Derivative (finance)","score":0.5051735043525696},{"id":"https://openalex.org/keywords/compartment","display_name":"Compartment (ship)","score":0.47135987877845764},{"id":"https://openalex.org/keywords/integer","display_name":"Integer (computer science)","score":0.457487016916275},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.44067448377609253},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.42350202798843384},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3646644353866577},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2761206030845642},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.22028952836990356},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1295832395553589},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.12894272804260254}],"concepts":[{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.9021593332290649},{"id":"https://openalex.org/C154249771","wikidata":"https://www.wikidata.org/wiki/Q1339058","display_name":"Fractional calculus","level":2,"score":0.7435191869735718},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.6097592711448669},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.5653596520423889},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5225883722305298},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5104910135269165},{"id":"https://openalex.org/C111771559","wikidata":"https://www.wikidata.org/wiki/Q66295","display_name":"Derivative (finance)","level":2,"score":0.5051735043525696},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.47135987877845764},{"id":"https://openalex.org/C97137487","wikidata":"https://www.wikidata.org/wiki/Q729138","display_name":"Integer (computer science)","level":2,"score":0.457487016916275},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.44067448377609253},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.42350202798843384},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3646644353866577},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2761206030845642},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22028952836990356},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1295832395553589},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.12894272804260254},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C106159729","wikidata":"https://www.wikidata.org/wiki/Q2294553","display_name":"Financial economics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cca.2013.6662769","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cca.2013.6662769","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Conference on Control Applications (CCA)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1584611818","https://openalex.org/W1606793285","https://openalex.org/W1968134101","https://openalex.org/W1998561306","https://openalex.org/W2020386396","https://openalex.org/W2032569514","https://openalex.org/W2041300691","https://openalex.org/W2060257705","https://openalex.org/W2060290820","https://openalex.org/W2069295222","https://openalex.org/W2071789713","https://openalex.org/W2076708105","https://openalex.org/W2077257134","https://openalex.org/W2083993851","https://openalex.org/W2088846739","https://openalex.org/W2091673881","https://openalex.org/W2091847420","https://openalex.org/W2102392294","https://openalex.org/W2115473091","https://openalex.org/W2126155630","https://openalex.org/W2261738981","https://openalex.org/W2493326547","https://openalex.org/W2787959293","https://openalex.org/W3193065799","https://openalex.org/W4250715407","https://openalex.org/W4299843271"],"related_works":["https://openalex.org/W2619303323","https://openalex.org/W4245462976","https://openalex.org/W2093423304","https://openalex.org/W2031913628","https://openalex.org/W2144143504","https://openalex.org/W2049495035","https://openalex.org/W4230720296","https://openalex.org/W1995799382","https://openalex.org/W2385307937","https://openalex.org/W2032672179"],"abstract_inverted_index":{"This":[0],"paper":[1],"presents":[2],"the":[3,7,17,30,36,62,69],"initial":[4],"steps":[5],"towards":[6],"development":[8],"of":[9,46,61,74],"a":[10,64],"compartmental":[11,72],"model":[12,26,48,67,73],"for":[13],"Propofol":[14,75],"diffusion":[15],"in":[16],"human":[18],"body":[19],"using":[20],"concepts":[21],"from":[22],"fractional":[23,65],"calculus.":[24],"The":[25,43],"presented":[27],"here":[28],"preserves":[29],"mass":[31],"balance,":[32],"therefore":[33],"it":[34],"maintains":[35],"link":[37],"between":[38,79],"physiological":[39],"and":[40,54,68],"mathematical":[41],"parameters.":[42],"final":[44],"purpose":[45],"this":[47],"is":[49],"to":[50],"predict":[51],"drug":[52],"pharmacokinetics":[53],"pharmacodynamics":[55],"during":[56],"general":[57],"anesthesia.":[58],"A":[59],"comparison":[60],"proposed":[63],"order":[66,71],"integer":[70],"shows":[76],"good":[77],"agreement":[78],"them.":[80]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}