{"id":"https://openalex.org/W2158294874","doi":"https://doi.org/10.1109/cca.2007.4389221","title":"Optimal Control of Polymorphic Transformation in Batch Pharmaceutical Crystallization","display_name":"Optimal Control of Polymorphic Transformation in Batch Pharmaceutical Crystallization","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W2158294874","doi":"https://doi.org/10.1109/cca.2007.4389221","mag":"2158294874"},"language":"en","primary_location":{"id":"doi:10.1109/cca.2007.4389221","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cca.2007.4389221","pdf_url":null,"source":{"id":"https://openalex.org/S4210212887","display_name":"\u0098The \u009cproceedings of the IEEE Conference on Control Applications/\u0098The \u009cproceedings of the ... IEEE Conference on Control Applications","issn_l":"1085-1992","issn":["1085-1992","2576-3210"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE International Conference on Control Applications","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111785475","display_name":"Martin Wijaya Hermanto","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Martin Wijaya Hermanto","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083684552","display_name":"Richard D. Braatz","orcid":"https://orcid.org/0000-0003-4304-3484"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Braatz","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana-Champaign, USA"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana-Champaign, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105412111","display_name":"Min\u2010Sen Chiu","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Min-Sen Chiu","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111785475"],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.36936937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":null,"first_page":"146","last_page":"151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.9886999726295471,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.9735000133514404,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/setpoint","display_name":"Setpoint","score":0.7490007877349854},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6945657730102539},{"id":"https://openalex.org/keywords/crystallization","display_name":"Crystallization","score":0.6475327014923096},{"id":"https://openalex.org/keywords/optimal-control","display_name":"Optimal control","score":0.5088675022125244},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4474742114543915},{"id":"https://openalex.org/keywords/batch-processing","display_name":"Batch processing","score":0.42917680740356445},{"id":"https://openalex.org/keywords/process-control","display_name":"Process control","score":0.42054593563079834},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.39530012011528015},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3019283413887024},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.2561439871788025},{"id":"https://openalex.org/keywords/chemical-engineering","display_name":"Chemical engineering","score":0.23761826753616333},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.2326734960079193},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.21198326349258423},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.16541516780853271},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.16164565086364746},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.08459305763244629}],"concepts":[{"id":"https://openalex.org/C12302492","wikidata":"https://www.wikidata.org/wiki/Q1752097","display_name":"Setpoint","level":2,"score":0.7490007877349854},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6945657730102539},{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.6475327014923096},{"id":"https://openalex.org/C91575142","wikidata":"https://www.wikidata.org/wiki/Q1971426","display_name":"Optimal control","level":2,"score":0.5088675022125244},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4474742114543915},{"id":"https://openalex.org/C172658912","wikidata":"https://www.wikidata.org/wiki/Q661613","display_name":"Batch processing","level":2,"score":0.42917680740356445},{"id":"https://openalex.org/C155386361","wikidata":"https://www.wikidata.org/wiki/Q1649571","display_name":"Process control","level":3,"score":0.42054593563079834},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.39530012011528015},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3019283413887024},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.2561439871788025},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.23761826753616333},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.2326734960079193},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.21198326349258423},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16541516780853271},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.16164565086364746},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08459305763244629},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/cca.2007.4389221","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cca.2007.4389221","pdf_url":null,"source":{"id":"https://openalex.org/S4210212887","display_name":"\u0098The \u009cproceedings of the IEEE Conference on Control Applications/\u0098The \u009cproceedings of the ... IEEE Conference on Control Applications","issn_l":"1085-1992","issn":["1085-1992","2576-3210"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE International Conference on Control Applications","raw_type":"proceedings-article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/74691","is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/74691","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Conference Paper"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/90659","is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/90659","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Conference Paper"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1529344387","https://openalex.org/W1967391483","https://openalex.org/W1988705394","https://openalex.org/W1990374810","https://openalex.org/W1997527285","https://openalex.org/W2008524228","https://openalex.org/W2009295391","https://openalex.org/W2030576928","https://openalex.org/W2033393434","https://openalex.org/W2038485845","https://openalex.org/W2039978520","https://openalex.org/W2043236696","https://openalex.org/W2087241199","https://openalex.org/W2119070716","https://openalex.org/W2310550205","https://openalex.org/W2952486139","https://openalex.org/W6698114476","https://openalex.org/W6765072312"],"related_works":["https://openalex.org/W1495927848","https://openalex.org/W1967033182","https://openalex.org/W3004171367","https://openalex.org/W1892941422","https://openalex.org/W2004331170","https://openalex.org/W2783790430","https://openalex.org/W2734855859","https://openalex.org/W1921954267","https://openalex.org/W2392733913","https://openalex.org/W2139185395"],"abstract_inverted_index":{"One":[0],"of":[1,12,20,48,55,73,77,91,173],"the":[2,10,18,30,46,56,69,74,81,85,89,101,116,132,164,171],"most":[3],"important":[4],"problems":[5],"that":[6,104,150,163],"can":[7,36,105],"arise":[8],"in":[9,22,100,107,112,115,131,143,156,170],"development":[11],"a":[13],"pharmaceutical":[14],"crystallization":[15,133],"process":[16],"is":[17],"control":[19,72,148],"polymorphism,":[21],"which":[23,44],"there":[24],"exist":[25],"different":[26,39],"crystal":[27],"forms":[28],"for":[29,176],"same":[31],"chemical":[32],"compound.":[33],"Different":[34],"polymorphs":[35],"have":[37],"very":[38],"properties":[40],"such":[41],"as":[42],"bioavailability,":[43],"motivates":[45],"design":[47,172],"controlled":[49],"processes":[50],"to":[51,59,84,98,110,124,145],"ensure":[52],"consistent":[53],"production":[54],"desired":[57],"polymorph":[58],"produce":[60],"reliable":[61],"therapeutic":[62],"benefits":[63],"upon":[64],"delivery.":[65],"This":[66],"paper":[67],"explores":[68],"optimal":[70,127,146],"batch":[71,93,139,158,178],"polymorphic":[75,177],"transformation":[76],"L-glutamic":[78],"acid":[79],"from":[80],"metastable":[82],"alpha-form":[83],"stable":[86],"beta-form,":[87],"with":[88],"goal":[90],"optimizing":[92],"productivity":[94,140],"while":[95],"providing":[96],"robustness":[97],"variations":[99,111],"physicochemical":[102],"parameters":[103],"occur":[106],"practice":[108],"due":[109],"contaminant":[113],"profiles":[114],"feedstocks.":[117],"A":[118],"nonlinear":[119],"state":[120],"feedback":[121],"controller":[122],"designed":[123],"follow":[125],"an":[126],"setpoint":[128],"trajectory":[129],"defined":[130],"phase":[134],"diagram":[135],"simultaneously":[136],"provided":[137],"high":[138],"and":[141],"robustness,":[142],"contrast":[144],"temperature":[147],"strategies":[149],"were":[151],"either":[152],"non-robust":[153],"or":[154],"resulted":[155],"long":[157],"times.":[159],"The":[160],"results":[161],"indicate":[162],"proposed":[165],"approach":[166],"should":[167],"be":[168],"incorporated":[169],"operating":[174],"procedures":[175],"crystallizations.":[179]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
