{"id":"https://openalex.org/W4412030910","doi":"https://doi.org/10.1109/cbms65348.2025.00117","title":"Identification of Novel Drug-Drug Interactions as Out-of-Distribution Samples","display_name":"Identification of Novel Drug-Drug Interactions as Out-of-Distribution Samples","publication_year":2025,"publication_date":"2025-06-18","ids":{"openalex":"https://openalex.org/W4412030910","doi":"https://doi.org/10.1109/cbms65348.2025.00117"},"language":"en","primary_location":{"id":"doi:10.1109/cbms65348.2025.00117","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms65348.2025.00117","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 38th International Symposium on Computer-Based Medical Systems (CBMS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5118822070","display_name":"Dimitrios Lezos","orcid":null},"institutions":[{"id":"https://openalex.org/I230915877","display_name":"The American College of Greece","ror":"https://ror.org/03vkake80","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I230915877"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Dimitrios Lezos","raw_affiliation_strings":["The American College of Greece-Deree,Athens,Greece"],"affiliations":[{"raw_affiliation_string":"The American College of Greece-Deree,Athens,Greece","institution_ids":["https://openalex.org/I230915877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111935279","display_name":"Dimitrios Vogiatzis","orcid":null},"institutions":[{"id":"https://openalex.org/I230915877","display_name":"The American College of Greece","ror":"https://ror.org/03vkake80","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I230915877"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Vogiatzis","raw_affiliation_strings":["The American College of Greece-Deree & National Center for Scientific Research, “Democritos”,Athens,Greece"],"affiliations":[{"raw_affiliation_string":"The American College of Greece-Deree & National Center for Scientific Research, “Democritos”,Athens,Greece","institution_ids":["https://openalex.org/I230915877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5118822070"],"corresponding_institution_ids":["https://openalex.org/I230915877"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17314274,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"549","last_page":"554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.9772999882698059,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.9772999882698059,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9395999908447266,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9004999995231628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.751806914806366},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6208209991455078},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4664812386035919},{"id":"https://openalex.org/keywords/distribution","display_name":"Distribution (mathematics)","score":0.4172172248363495},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.25056397914886475},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2169283628463745},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11468088626861572},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07493430376052856}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.751806914806366},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6208209991455078},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4664812386035919},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.4172172248363495},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25056397914886475},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2169283628463745},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11468088626861572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07493430376052856},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cbms65348.2025.00117","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms65348.2025.00117","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 38th International Symposium on Computer-Based Medical Systems (CBMS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1578104218","https://openalex.org/W1975147762","https://openalex.org/W2119002393","https://openalex.org/W2127069089","https://openalex.org/W2145578524","https://openalex.org/W2177317049","https://openalex.org/W2523679382","https://openalex.org/W2596142952","https://openalex.org/W2742545337","https://openalex.org/W2777416523","https://openalex.org/W2786016794","https://openalex.org/W2791355014","https://openalex.org/W2802200505","https://openalex.org/W2910453440","https://openalex.org/W2911489562","https://openalex.org/W2913447635","https://openalex.org/W2963078194","https://openalex.org/W2995394700","https://openalex.org/W2995738274","https://openalex.org/W3030536242","https://openalex.org/W3108975329","https://openalex.org/W3197380122","https://openalex.org/W4210567899","https://openalex.org/W4247637183","https://openalex.org/W4285787895","https://openalex.org/W4312284582","https://openalex.org/W4384559900","https://openalex.org/W4388615774","https://openalex.org/W4389523847","https://openalex.org/W4391737993","https://openalex.org/W4391785342","https://openalex.org/W4396662985","https://openalex.org/W4399929809","https://openalex.org/W4401024402","https://openalex.org/W4405830662","https://openalex.org/W6621740533","https://openalex.org/W6713147065","https://openalex.org/W6810300553","https://openalex.org/W6810308849"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"This":[0],"work":[1],"proposes":[2],"a":[3,55,69,85],"novel":[4,74,133],"approach":[5,87],"to":[6,36,96,120,128],"predicting":[7],"side":[8,75],"effects":[9,76],"in":[10,48],"drug-drug":[11],"interactions":[12,45],"(DDIs)":[13],"by":[14],"identifying":[15],"them":[16],"as":[17,68,135],"Out":[18],"of":[19,25,32,41,132],"Distribution":[20],"(OoD)":[21],"samples.":[22,137],"The":[23],"rise":[24],"polypharmacy":[26],"has":[27],"increased":[28],"both":[29],"the":[30,39,130],"number":[31],"drug":[33,91,104],"combinations":[34],"administered":[35],"patients":[37],"and":[38,117],"risk":[40],"DDIs,":[42],"many":[43],"such":[44],"remain":[46],"undocumented":[47],"clinical":[49],"trials":[50],"or":[51],"medical":[52],"records,":[53],"posing":[54],"significant":[56],"challenge":[57],"for":[58],"patient":[59],"safety.":[60],"While":[61],"traditional":[62],"DDI":[63],"prediction":[64],"is":[65],"typically":[66],"framed":[67],"supervised":[70],"machine":[71],"learning":[72],"problem,":[73],"lack":[77],"labeled":[78],"data.":[79],"To":[80],"address":[81],"this,":[82],"we":[83],"introduce":[84],"hybrid":[86],"that":[88,125],"combines":[89],"diverse":[90,108],"representations":[92,124],"with":[93],"OoD":[94,136],"detection":[95],"capture":[97],"unseen":[98],"interactions.":[99],"Our":[100],"method":[101],"integrates":[102],"multiple":[103],"embeddings":[105],"generated":[106],"from":[107],"characteristics,":[109],"including":[110],"biomedical":[111],"texts,":[112],"molecular":[113],"structures,":[114],"knowledge":[115],"graphs":[116],"similarity":[118],"profiles":[119],"generate":[121],"rich":[122],"latent":[123],"enable":[126],"us":[127],"predict":[129],"presence":[131],"DDIs":[134]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}