{"id":"https://openalex.org/W2117294425","doi":"https://doi.org/10.1109/cbms.2011.5999026","title":"A retrospective study of paediatric health and development following pre-implantation genetic diagnosis and screening","display_name":"A retrospective study of paediatric health and development following pre-implantation genetic diagnosis and screening","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W2117294425","doi":"https://doi.org/10.1109/cbms.2011.5999026","mag":"2117294425"},"language":"en","primary_location":{"id":"doi:10.1109/cbms.2011.5999026","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms.2011.5999026","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 24th International Symposium on Computer-Based Medical Systems (CBMS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010368794","display_name":"Mark Olive","orcid":null},"institutions":[{"id":"https://openalex.org/I178535277","display_name":"University of the West of England","ror":"https://ror.org/02nwg5t34","country_code":"GB","type":"education","lineage":["https://openalex.org/I178535277"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mark Olive","raw_affiliation_strings":["University of the West of England, Bristol, UK","University of the West of England Bristol, UK"],"affiliations":[{"raw_affiliation_string":"University of the West of England, Bristol, UK","institution_ids":["https://openalex.org/I178535277"]},{"raw_affiliation_string":"University of the West of England Bristol, UK","institution_ids":["https://openalex.org/I178535277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081418288","display_name":"Alison Lashwood","orcid":null},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alison Lashwood","raw_affiliation_strings":["Centre of PGD, Guy's Hospital, London, UK","Centre for PGD, Guy's Hospital, London, UK"],"affiliations":[{"raw_affiliation_string":"Centre of PGD, Guy's Hospital, London, UK","institution_ids":["https://openalex.org/I1298207432"]},{"raw_affiliation_string":"Centre for PGD, Guy's Hospital, London, UK","institution_ids":["https://openalex.org/I1298207432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045496089","display_name":"Tony Solomonides","orcid":null},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tony Solomonides","raw_affiliation_strings":["Biosciences, University of Exeter, UK"],"affiliations":[{"raw_affiliation_string":"Biosciences, University of Exeter, UK","institution_ids":["https://openalex.org/I23923803"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010368794"],"corresponding_institution_ids":["https://openalex.org/I178535277"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14975214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/miscarriage","display_name":"Miscarriage","score":0.7056705355644226},{"id":"https://openalex.org/keywords/retrospective-cohort-study","display_name":"Retrospective cohort study","score":0.6647124886512756},{"id":"https://openalex.org/keywords/abnormality","display_name":"Abnormality","score":0.4987637996673584},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.49076828360557556},{"id":"https://openalex.org/keywords/pediatrics","display_name":"Pediatrics","score":0.44844183325767517},{"id":"https://openalex.org/keywords/incidence","display_name":"Incidence (geometry)","score":0.4476635456085205},{"id":"https://openalex.org/keywords/obstetrics","display_name":"Obstetrics","score":0.44115734100341797},{"id":"https://openalex.org/keywords/pregnancy","display_name":"Pregnancy","score":0.39792564511299133},{"id":"https://openalex.org/keywords/gynecology","display_name":"Gynecology","score":0.3575495779514313},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26648831367492676},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16592901945114136},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1545482873916626}],"concepts":[{"id":"https://openalex.org/C2779245376","wikidata":"https://www.wikidata.org/wiki/Q28693","display_name":"Miscarriage","level":3,"score":0.7056705355644226},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6647124886512756},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.4987637996673584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49076828360557556},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.44844183325767517},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4476635456085205},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.44115734100341797},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.39792564511299133},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3575495779514313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26648831367492676},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16592901945114136},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1545482873916626},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cbms.2011.5999026","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms.2011.5999026","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 24th International Symposium on Computer-Based Medical Systems (CBMS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327370","display_name":"European Society of\u00a0Human Reproduction and Embryology","ror":"https://ror.org/028sbah75"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1519399388","https://openalex.org/W1974346013","https://openalex.org/W1999086819","https://openalex.org/W2039578770","https://openalex.org/W2050933700","https://openalex.org/W2056995500","https://openalex.org/W2058062950","https://openalex.org/W2060684604","https://openalex.org/W2061929853","https://openalex.org/W2062082156","https://openalex.org/W2066312343","https://openalex.org/W2084064168","https://openalex.org/W2086841224","https://openalex.org/W2095186023","https://openalex.org/W2095666069","https://openalex.org/W2104295025","https://openalex.org/W2104460736","https://openalex.org/W2113308856","https://openalex.org/W2114109183","https://openalex.org/W2116073351","https://openalex.org/W2120673872","https://openalex.org/W2129259025","https://openalex.org/W2140744381","https://openalex.org/W2144597014","https://openalex.org/W2159365183","https://openalex.org/W2160851788","https://openalex.org/W2169743447","https://openalex.org/W2169812048","https://openalex.org/W2187963297","https://openalex.org/W2321800574","https://openalex.org/W4234708366","https://openalex.org/W4238561221"],"related_works":["https://openalex.org/W2057156863","https://openalex.org/W1963932479","https://openalex.org/W2048833152","https://openalex.org/W1755616925","https://openalex.org/W2121096509","https://openalex.org/W2039758761","https://openalex.org/W2016096381","https://openalex.org/W2897706689","https://openalex.org/W2041600248","https://openalex.org/W4280587292"],"abstract_inverted_index":{"Pre-implantation":[0],"genetic":[1,20],"diagnosis":[2],"and":[3,6,48,51,76,83,109,130,155],"screening":[4],"(PGD":[5],"PGS)":[7],"are":[8,15,46,55,135],"treatments":[9],"for":[10,57,66,189,205],"patients":[11],"that":[12,136],"have":[13,24,121,180],"(or":[14],"carriers":[16],"of)":[17],"an":[18,90],"inherited":[19],"disorder,":[21],"or":[22,63],"who":[23],"had":[25],"a":[26,42,103,173,200],"history":[27],"of":[28,44,53,78,105,118,150,158,170,175,177,193],"miscarriage,":[29],"problems":[30,160],"with":[31],"embryo":[32],"implantation,":[33],"etc.":[34],"Often":[35],"conducted":[36],"alongside":[37],"assisted":[38],"reproductive":[39],"technologies":[40],"(ART),":[41],"number":[43,104,117,174],"embryos":[45],"produced,":[47],"the":[49,74,95,126,137,146,156,171,187,190],"DNA":[50],"chromosomes":[52],"each":[54],"tested":[56],"various":[58],"disorders":[59],"by":[60,89,94],"removing":[61],"one":[62],"two":[64],"cells":[65],"analysis.":[67,207],"A":[68,116],"retrospective":[69,129],"cross-sectional":[70],"study":[71],"looking":[72],"at":[73,143],"health":[75,159],"development":[77],"children":[79],"born":[80],"following":[81],"PGD":[82,151],"PGS":[84],"is":[85,141],"now":[86],"underway,":[87],"aided":[88],"online":[91,184],"system":[92,185],"developed":[93],"EuroPGDcode":[96],"project.":[97],"Data":[98],"has":[99,110],"been":[100,111,122,181],"collected":[101],"from":[102],"ART/PGD":[106],"centres":[107],"worldwide,":[108],"entered":[112],"into":[113],"this":[114],"system.":[115],"complex":[119],"queries":[120],"constructed":[123],"to":[124,167,196],"interrogate":[125],"data;":[127],"although":[128],"not":[131],"case":[132],"controlled,":[133],"indications":[134],"birth":[138,162],"abnormality":[139],"rate":[140],"low":[142],"1.42%.":[144],"However":[145],"special":[147],"care":[148],"requirements":[149],"infants":[152],"was":[153,163],"22.9%":[154],"incidence":[157],"after":[161],"22.3%.":[164],"In":[165],"addition":[166],"statistical":[168],"analysis":[169],"data,":[172],"cases":[176,195],"particular":[178],"interest":[179],"identified.":[182],"The":[183],"provides":[186],"facility":[188],"full":[191],"details":[192],"these":[194],"be":[197],"exported":[198],"in":[199],"specially":[201],"designed":[202],"XML":[203],"format":[204],"further":[206]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
