{"id":"https://openalex.org/W4245806362","doi":"https://doi.org/10.1109/cbms.2004.1311740","title":"A comparison of pharmacokinetic models of dynamic contrast enhanced MRI","display_name":"A comparison of pharmacokinetic models of dynamic contrast enhanced MRI","publication_year":2004,"publication_date":"2004-10-04","ids":{"openalex":"https://openalex.org/W4245806362","doi":"https://doi.org/10.1109/cbms.2004.1311740"},"language":"en","primary_location":{"id":"doi:10.1109/cbms.2004.1311740","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms.2004.1311740","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. 17th IEEE Symposium on Computer-Based Medical Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034622598","display_name":"R. Srikanchana","orcid":null},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. Srikanchana","raw_affiliation_strings":["National Cancer Institute, Bethesda, MD, USA"],"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038195086","display_name":"D. Thomasson","orcid":null},"institutions":[{"id":"https://openalex.org/I1299022934","display_name":"United States Department of Health and Human Services","ror":"https://ror.org/033jnv181","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Thomasson","raw_affiliation_strings":["National Institutes of Health DHHS, Bethesda, MD, USA"],"affiliations":[{"raw_affiliation_string":"National Institutes of Health DHHS, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028638131","display_name":"P. Choyke","orcid":null},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Choyke","raw_affiliation_strings":["National Cancer Institute, Bethesda, MD, USA"],"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074650256","display_name":"A. Dwyer","orcid":null},"institutions":[{"id":"https://openalex.org/I1299022934","display_name":"United States Department of Health and Human Services","ror":"https://ror.org/033jnv181","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Dwyer","raw_affiliation_strings":["National Institutes of Health DHHS, Bethesda, MD, USA"],"affiliations":[{"raw_affiliation_string":"National Institutes of Health DHHS, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034622598"],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":0.2638,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.67677084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"16","issue":null,"first_page":"361","last_page":"366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynamic-contrast-enhanced-mri","display_name":"Dynamic contrast-enhanced MRI","score":0.741987943649292},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.6302149891853333},{"id":"https://openalex.org/keywords/dynamic-contrast","display_name":"Dynamic contrast","score":0.62464439868927},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.6197735667228699},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4715316891670227},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.40252286195755005},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3350437879562378},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.22076132893562317},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.18250930309295654},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1332891583442688}],"concepts":[{"id":"https://openalex.org/C41727105","wikidata":"https://www.wikidata.org/wiki/Q17009718","display_name":"Dynamic contrast-enhanced MRI","level":3,"score":0.741987943649292},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.6302149891853333},{"id":"https://openalex.org/C2994142346","wikidata":"https://www.wikidata.org/wiki/Q353268","display_name":"Dynamic contrast","level":3,"score":0.62464439868927},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6197735667228699},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4715316891670227},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.40252286195755005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3350437879562378},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.22076132893562317},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.18250930309295654},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1332891583442688}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cbms.2004.1311740","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms.2004.1311740","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. 17th IEEE Symposium on Computer-Based Medical Systems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2036913456","https://openalex.org/W2042098439","https://openalex.org/W2065637833","https://openalex.org/W2092078486","https://openalex.org/W2108610949"],"related_works":["https://openalex.org/W2299779964","https://openalex.org/W2419198331","https://openalex.org/W2117889023","https://openalex.org/W2144450524","https://openalex.org/W2317772852","https://openalex.org/W4391191811","https://openalex.org/W2377517991","https://openalex.org/W2347317511","https://openalex.org/W2783825050","https://openalex.org/W2996905865"],"abstract_inverted_index":{"Dynamic":[0],"contrast":[1],"enhanced":[2],"MRI":[3,36,50,58],"(DCE-MRI)":[4],"is":[5,25],"often":[6],"employed":[7],"as":[8],"an":[9],"indicator":[10],"of":[11,17,49,56],"drug":[12],"activity":[13],"in":[14,61,73,75],"clinical":[15],"trials":[16],"angiogenic":[18],"inhibitors.":[19],"The":[20],"data":[21],"obtained":[22],"with":[23,91],"DCE-MRI":[24,74],"reported":[26],"semi":[27],"quantitatively":[28],"using":[29],"parameters":[30],"derived":[31],"from":[32,41],"pharmacokinetic":[33,70],"models.":[34],"Most":[35],"kinetic":[37],"models":[38,59,71,88],"were":[39],"developed":[40],"nuclear":[42],"medicine":[43],"quantitative":[44],"studies":[45],"but":[46],"the":[47,79],"limitations":[48],"dictated":[51],"specific":[52],"modifications.":[53],"A":[54],"number":[55],"these":[57],"are":[60,89],"current":[62],"use.":[63],"In":[64],"this":[65],"work,":[66],"we":[67],"review":[68],"several":[69],"used":[72],"order":[76],"to":[77,83,93],"determine":[78],"most":[80],"appropriate":[81],"model":[82],"assess":[84],"tumor":[85],"angiogenesis.":[86],"These":[87],"compared":[90],"respect":[92],"their":[94],"physiological":[95],"appropriateness;":[96],"compartmental":[97],"analysis;":[98],"initial":[99],"and":[100,103],"boundary":[101],"conditions;":[102],"clinically":[104],"relevant":[105],"output":[106],"parameters.":[107]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}