{"id":"https://openalex.org/W1856350364","doi":"https://doi.org/10.1109/cbms.2003.1212799","title":"Flow cytometry, MRI, PET and NMR spectroscopy methods of non-invasive drug monitoring in prostate tumor","display_name":"Flow cytometry, MRI, PET and NMR spectroscopy methods of non-invasive drug monitoring in prostate tumor","publication_year":2003,"publication_date":"2003-11-04","ids":{"openalex":"https://openalex.org/W1856350364","doi":"https://doi.org/10.1109/cbms.2003.1212799","mag":"1856350364"},"language":"en","primary_location":{"id":"doi:10.1109/cbms.2003.1212799","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms.2003.1212799","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"16th IEEE Symposium Computer-Based Medical Systems, 2003. Proceedings.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022025952","display_name":"Rakesh Sharma","orcid":"https://orcid.org/0000-0002-9418-2655"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. Sharma","raw_affiliation_strings":["Departments of Radiology and Medicine, Columbia University, New York, NY, USA","Dept. of Radiol., Columbia Univ., New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Departments of Radiology and Medicine, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Dept. of Radiol., Columbia Univ., New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014515252","display_name":"Richard Kline","orcid":"https://orcid.org/0000-0001-8048-2107"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Kline","raw_affiliation_strings":["Departments of Radiology and Medicine, Columbia University, New York, NY, USA","Dept. of Radiol., Columbia Univ., New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Departments of Radiology and Medicine, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Dept. of Radiol., Columbia Univ., New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022025952"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":0.3507,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.54636744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"6","issue":null,"first_page":"263","last_page":"268"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.988099992275238,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.6816948652267456},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"Flow cytometry","score":0.6451074481010437},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.6445000171661377},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5210992097854614},{"id":"https://openalex.org/keywords/feulgen-stain","display_name":"Feulgen stain","score":0.481862872838974},{"id":"https://openalex.org/keywords/etoposide","display_name":"Etoposide","score":0.46736428141593933},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.41574621200561523},{"id":"https://openalex.org/keywords/lncap","display_name":"LNCaP","score":0.41514962911605835},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3956207036972046},{"id":"https://openalex.org/keywords/prostate","display_name":"Prostate","score":0.39542049169540405},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.3834023177623749},{"id":"https://openalex.org/keywords/staining","display_name":"Staining","score":0.3329876661300659},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3323368728160858},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"Programmed cell death","score":0.322104811668396},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.2770598232746124},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24944207072257996},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24927037954330444},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1351487934589386},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.10350334644317627},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.0884101390838623}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6816948652267456},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6451074481010437},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.6445000171661377},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5210992097854614},{"id":"https://openalex.org/C62649737","wikidata":"https://www.wikidata.org/wiki/Q902526","display_name":"Feulgen stain","level":3,"score":0.481862872838974},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.46736428141593933},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41574621200561523},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.41514962911605835},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3956207036972046},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.39542049169540405},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3834023177623749},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.3329876661300659},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3323368728160858},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.322104811668396},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2770598232746124},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24944207072257996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24927037954330444},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1351487934589386},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10350334644317627},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0884101390838623}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cbms.2003.1212799","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms.2003.1212799","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"16th IEEE Symposium Computer-Based Medical Systems, 2003. Proceedings.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1512072225","https://openalex.org/W1753882717","https://openalex.org/W2019763910","https://openalex.org/W2026103498","https://openalex.org/W2081176367","https://openalex.org/W2414196731","https://openalex.org/W2442104692"],"related_works":["https://openalex.org/W2366459649","https://openalex.org/W2348196707","https://openalex.org/W1982753865","https://openalex.org/W2026798730","https://openalex.org/W2473370993","https://openalex.org/W1514000584","https://openalex.org/W2049633380","https://openalex.org/W2462079367","https://openalex.org/W1002149273","https://openalex.org/W2465077057"],"abstract_inverted_index":{"PET":[0,261,275],"and":[1,17,30,51,72,82,99,108,115,128,133,141,196,209,220,257,274,281],"MW":[2],"images":[3,136,256],"of":[4,25,48,53,88,176],"mouse":[5],"prostate":[6],"tumors":[7,178],"were":[8,42,59,119,184,226],"correlated":[9],"with":[10,44,61,167,247],"histology,":[11],"flow":[12],"cytometry,":[13],"DNA":[14,49,250],"fragmentation":[15,50],"analysis":[16],"NMR":[18,54,80,236,277],"peaks.":[19,270],"Hypotheses":[20],"were:":[21],"1.":[22],"signal":[23,40,143],"intensities":[24,41,144],"intracellular":[26,239],"sodium":[27,142,272],"(/spl":[28,33],"mu/MRI)":[29],"flouro-2-deoxy-glucose":[31],"utilization":[32],"mu/PET)":[34],"increased":[35,138,164],"in":[36,66,145,153,214,283],"tumors;":[37],"2.":[38],"image":[39],"associated":[43],"apoptosis":[45,83,280],"as":[46],"result":[47],"accumulation":[52],"visible":[55],"metabolites.PC-3":[56],"cell":[57,64,78],"lines":[58,65],"compared":[60],"DU-145,":[62],"LNCaP":[63],"culture":[67],"for":[68,85,122,186],"the":[69],"[Na]/sub":[70],"i/":[71],"[Ca]/sub":[73],"l/":[74],"ion":[75],"sensing":[76],"dyes,":[77],"death":[79],"peaks":[81,237,278],"staining":[84,124],"chemotherapeutic":[86],"action":[87],"different":[89],"drugs.":[90],"After":[91],"PC3":[92],"tumor":[93,169,188,200],"imaging,":[94,276],"taxotere":[95,149],"(40":[96],"mg/kg;":[97,103],"n=5)":[98],"VP-16":[100],"etoposide":[101],"(1.2":[102],"n=7)":[104],"was":[105,110],"administered":[106],"i.v.":[107],"imaging":[109],"done":[111],"after":[112,159,179],"12":[113],"hours":[114],"24":[116,160,180],"hours.":[117,161,181],"Tumors":[118],"taken":[120],"out":[121],"immunohistological":[123],"by":[125],"pentachrome,":[126],"feulgen":[127],"ss-DNA":[129],"antibody.":[130],"/spl":[131,134,217],"mu/PET":[132,218],"mu/MRI":[135],"showed":[137,229,244,266],"18-FDG":[139],"uptake":[140,163],"tumor.":[146],"In":[147],"tumors,":[148],"induced":[150],"an":[151],"increase":[152,158],"IC-Na":[154,255],"30":[155],"%":[156],"(p<0.001)":[157],"FDG":[162],"15":[165],"%(p<0.001)":[166],"decreased":[168,199],"size":[170],"(10":[171],"%;":[172],"p<0.001)":[173],"than":[174],"that":[175,228],"control":[177],"Histological":[182],"features":[183,213],"analyzed":[185],"high":[187,193,268],"risk":[189],"(high":[190],"'IC/EC":[191],"ratio',":[192],"mitotic":[194,203],"index":[195],"apoptotic":[197],"index),":[198],"viability":[201],"(reduced":[202],"figures,":[204],"reduced":[205],"diploidy":[206],"or":[207],"aneuploidy":[208],"proliferation":[210],"index).":[211],"These":[212],"co-registered":[215],"IC-Na,":[216],"hypermetabolic":[219],"monoclonal":[221],"antibody":[222],"(ss-DNA)":[223],"sensitive":[224],"regions":[225,243],"identified":[227],"(%":[230],"difference":[231],">":[232],"6":[233],"%).":[234],"Sodium":[235],"isolated":[238],"sodium.":[240],"Apoptosis":[241],"rich":[242],"characteristic":[245,267],"nuclei":[246],"S":[248],"phase":[249],"histogram,":[251],"appearing":[252],"brighter":[253],"on":[254,260],"mild":[258],"active":[259],"images.":[262],"/sup":[263],"31/P-NMR":[264],"spectra":[265],"phospho-choline":[269],"Integrated":[271],"MRI":[273],"indicated":[279],"offers":[282],"vivo":[284],"drug":[285],"monitoring":[286],"method.":[287]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}