{"id":"https://openalex.org/W2793237812","doi":"https://doi.org/10.1109/camsap.2017.8313166","title":"Photon-Limited fluorescence lifetime imaging microscopy signal recovery with known bounds","display_name":"Photon-Limited fluorescence lifetime imaging microscopy signal recovery with known bounds","publication_year":2017,"publication_date":"2017-12-01","ids":{"openalex":"https://openalex.org/W2793237812","doi":"https://doi.org/10.1109/camsap.2017.8313166","mag":"2793237812"},"language":"en","primary_location":{"id":"doi:10.1109/camsap.2017.8313166","is_oa":false,"landing_page_url":"https://doi.org/10.1109/camsap.2017.8313166","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE 7th International Workshop on Computational Advances in Multi-Sensor Adaptive Processing (CAMSAP)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030231957","display_name":"Omar DeGuchy","orcid":null},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Omar DeGuchy","raw_affiliation_strings":["Applied Mathematics, University of California Merced, Merced, CA"],"affiliations":[{"raw_affiliation_string":"Applied Mathematics, University of California Merced, Merced, CA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003506092","display_name":"Lasith Adhikari","orcid":"https://orcid.org/0000-0002-3252-8972"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lasith Adhikari","raw_affiliation_strings":["Department of Medicine, University of Florida, Gainesville, FL"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036191326","display_name":"Arnold D. Kim","orcid":"https://orcid.org/0000-0002-8945-4038"},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnold Kim","raw_affiliation_strings":["Applied Mathematics, University of California Merced, Merced, CA"],"affiliations":[{"raw_affiliation_string":"Applied Mathematics, University of California Merced, Merced, CA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005703929","display_name":"Roummel F. Marcia","orcid":"https://orcid.org/0000-0001-6838-140X"},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roummel F. Marcia","raw_affiliation_strings":["Applied Mathematics, University of California Merced, Merced, CA"],"affiliations":[{"raw_affiliation_string":"Applied Mathematics, University of California Merced, Merced, CA","institution_ids":["https://openalex.org/I156087764"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030231957"],"corresponding_institution_ids":["https://openalex.org/I156087764"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.207385,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"39","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorophore","display_name":"Fluorophore","score":0.72187340259552},{"id":"https://openalex.org/keywords/photon","display_name":"Photon","score":0.5662893056869507},{"id":"https://openalex.org/keywords/bounded-function","display_name":"Bounded function","score":0.5552200078964233},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.5448151230812073},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.5290157794952393},{"id":"https://openalex.org/keywords/poisson-distribution","display_name":"Poisson distribution","score":0.5006289482116699},{"id":"https://openalex.org/keywords/two-photon-excitation-microscopy","display_name":"Two-photon excitation microscopy","score":0.4616377055644989},{"id":"https://openalex.org/keywords/norm","display_name":"Norm (philosophy)","score":0.44224950671195984},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.4264487326145172},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4141137897968292},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.36015185713768005},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.35663044452667236},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3144019842147827},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.3105965554714203},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.17148756980895996},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.10335063934326172},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07394161820411682}],"concepts":[{"id":"https://openalex.org/C2778617687","wikidata":"https://www.wikidata.org/wiki/Q2448456","display_name":"Fluorophore","level":3,"score":0.72187340259552},{"id":"https://openalex.org/C159317903","wikidata":"https://www.wikidata.org/wiki/Q3198","display_name":"Photon","level":2,"score":0.5662893056869507},{"id":"https://openalex.org/C34388435","wikidata":"https://www.wikidata.org/wiki/Q2267362","display_name":"Bounded function","level":2,"score":0.5552200078964233},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5448151230812073},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5290157794952393},{"id":"https://openalex.org/C100906024","wikidata":"https://www.wikidata.org/wiki/Q205692","display_name":"Poisson distribution","level":2,"score":0.5006289482116699},{"id":"https://openalex.org/C47785574","wikidata":"https://www.wikidata.org/wiki/Q373859","display_name":"Two-photon excitation microscopy","level":3,"score":0.4616377055644989},{"id":"https://openalex.org/C191795146","wikidata":"https://www.wikidata.org/wiki/Q3878446","display_name":"Norm (philosophy)","level":2,"score":0.44224950671195984},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.4264487326145172},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4141137897968292},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36015185713768005},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.35663044452667236},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3144019842147827},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.3105965554714203},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.17148756980895996},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10335063934326172},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07394161820411682},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/camsap.2017.8313166","is_oa":false,"landing_page_url":"https://doi.org/10.1109/camsap.2017.8313166","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE 7th International Workshop on Computational Advances in Multi-Sensor Adaptive Processing (CAMSAP)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W10332844","https://openalex.org/W1481249341","https://openalex.org/W1586180564","https://openalex.org/W1977637828","https://openalex.org/W1980759701","https://openalex.org/W1997649863","https://openalex.org/W2001020189","https://openalex.org/W2004956687","https://openalex.org/W2033106066","https://openalex.org/W2076605490","https://openalex.org/W2077502289","https://openalex.org/W2133863204","https://openalex.org/W2135236030","https://openalex.org/W2143163067","https://openalex.org/W2147229775","https://openalex.org/W2148791483","https://openalex.org/W2466977012","https://openalex.org/W2491458126","https://openalex.org/W2514447582","https://openalex.org/W2605380276","https://openalex.org/W2769426822","https://openalex.org/W3098521737","https://openalex.org/W3121742466","https://openalex.org/W4240290094","https://openalex.org/W4244063180","https://openalex.org/W6745719433","https://openalex.org/W6959831456"],"related_works":["https://openalex.org/W20207498","https://openalex.org/W3009767981","https://openalex.org/W4318391750","https://openalex.org/W2386190268","https://openalex.org/W4244013499","https://openalex.org/W2315036349","https://openalex.org/W1828367075","https://openalex.org/W2460366041","https://openalex.org/W2157527564","https://openalex.org/W4241983684"],"abstract_inverted_index":{"In":[0,100],"this":[1],"paper,":[2],"we":[3,33,57],"describe":[4],"numerical":[5,136],"methods":[6],"for":[7],"recovering":[8],"signals":[9],"from":[10],"photon-limited":[11,24],"fluorescence":[12,48,147],"microscopy.":[13],"Under":[14],"the":[15,18,35,40,47,59,71,101,104,110,117,121,127,139,142],"assumption":[16],"that":[17,56,84],"observation":[19],"of":[20,39,52,141],"photons":[21],"in":[22],"a":[23,30,63,79,91,113,145],"regime":[25],"is":[26,55,74,85,106,119,124],"best":[27],"modeled":[28],"using":[29],"Poisson":[31,81],"statistic,":[32],"recover":[34],"support":[36,105,118],"or":[37],"location":[38,122],"fluorophores,":[41],"along":[42],"with":[43],"their":[44],"concentrations":[45],"and":[46],"lifetime.":[49],"The":[50,76],"novelty":[51],"our":[53],"approach":[54,143],"formulate":[58],"reconstruction":[60,133],"problem":[61,66],"as":[62],"bounded":[64],"optimization":[65],"where":[67,94],"bound":[68,128],"information":[69,123],"on":[70,144],"fluorophore":[72],"intensity":[73],"known.":[75],"formulation":[77],"involves":[78],"negative":[80],"log-likelihood":[82],"function":[83],"penalized":[86],"to":[87,112,130],"promote":[88],"sparsity":[89],"by":[90,108],"non-convex":[92],"p-norm":[93],"0":[95],"\u2264":[96],"p":[97],"<;":[98],"1.":[99],"first":[102],"stage,":[103],"determined":[107],"relaxing":[109],"bounds":[111],"non-negative":[114],"constraint.":[115],"Once":[116],"recovered,":[120],"incorporated":[125],"into":[126],"constraints":[129],"improve":[131],"signal":[132],"accuracy.":[134],"A":[135],"experiment":[137],"demonstrates":[138],"effectiveness":[140],"2-D":[146],"lifetime":[148],"imaging":[149],"microscopy":[150],"problem.":[151]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}