{"id":"https://openalex.org/W2289419227","doi":"https://doi.org/10.1109/bmei.2015.7401546","title":"MicroRNA and gene expression profiling of response to lithium treatment for bipolar I disorder","display_name":"MicroRNA and gene expression profiling of response to lithium treatment for bipolar I disorder","publication_year":2015,"publication_date":"2015-10-01","ids":{"openalex":"https://openalex.org/W2289419227","doi":"https://doi.org/10.1109/bmei.2015.7401546","mag":"2289419227"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2015.7401546","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2015.7401546","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 8th International Conference on Biomedical Engineering and Informatics (BMEI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102950025","display_name":"Julia Weng","orcid":"https://orcid.org/0000-0003-0127-0945"},"institutions":[{"id":"https://openalex.org/I99908691","display_name":"Yuan Ze University","ror":"https://ror.org/01fv1ds98","country_code":"TW","type":"education","lineage":["https://openalex.org/I99908691"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Julia Tzu-Ya Weng","raw_affiliation_strings":["Department of Computer Science & Engineering, Yuan Ze University, Chung-Li, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science & Engineering, Yuan Ze University, Chung-Li, Taiwan","institution_ids":["https://openalex.org/I99908691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049249019","display_name":"Yu-Xiang Chi","orcid":null},"institutions":[{"id":"https://openalex.org/I99908691","display_name":"Yuan Ze University","ror":"https://ror.org/01fv1ds98","country_code":"TW","type":"education","lineage":["https://openalex.org/I99908691"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Xiang Chi","raw_affiliation_strings":["Department of Computer Science & Engineering, Yuan Ze University, Chung-Li, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science & Engineering, Yuan Ze University, Chung-Li, Taiwan","institution_ids":["https://openalex.org/I99908691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111534556","display_name":"Lawrence Shih\u2010Hsin Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I189772984","display_name":"Tzu Chi University","ror":"https://ror.org/04ss1bw11","country_code":"TW","type":"education","lineage":["https://openalex.org/I189772984"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Lawrence Shih-Hsin Wu","raw_affiliation_strings":["Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan","institution_ids":["https://openalex.org/I189772984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080257216","display_name":"Chau\u2010Shoun Lee","orcid":"https://orcid.org/0000-0002-1509-4340"},"institutions":[{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chau-Shoun Lee","raw_affiliation_strings":["Department of Psychiatry, Mackay Memorial Hospital, New Taipei City, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Mackay Memorial Hospital, New Taipei City, Taiwan","institution_ids":["https://openalex.org/I2802753785"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112897132","display_name":"Andrew T. A. Cheng","orcid":null},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Andrew T. A. Cheng","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210096666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5102950025"],"corresponding_institution_ids":["https://openalex.org/I99908691"],"apc_list":null,"apc_paid":null,"fwci":0.2052,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59524487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"19","issue":null,"first_page":"446","last_page":"452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9797999858856201,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"Bipolar disorder","score":0.8806774020195007},{"id":"https://openalex.org/keywords/mania","display_name":"Mania","score":0.7211845517158508},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7058228254318237},{"id":"https://openalex.org/keywords/lithium","display_name":"Lithium (medication)","score":0.5900857448577881},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene ontology","score":0.572607696056366},{"id":"https://openalex.org/keywords/mood","display_name":"Mood","score":0.4975493252277374},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4794924855232239},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4700694680213928},{"id":"https://openalex.org/keywords/mood-disorders","display_name":"Mood disorders","score":0.4622589647769928},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4357939064502716},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.43091240525245667},{"id":"https://openalex.org/keywords/depression","display_name":"Depression (economics)","score":0.4185722768306732},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41447293758392334},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3733397424221039},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.3507966101169586},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2838905453681946},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22471469640731812},{"id":"https://openalex.org/keywords/anxiety","display_name":"Anxiety","score":0.16011488437652588}],"concepts":[{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.8806774020195007},{"id":"https://openalex.org/C2776809841","wikidata":"https://www.wikidata.org/wiki/Q185935","display_name":"Mania","level":4,"score":0.7211845517158508},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7058228254318237},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.5900857448577881},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.572607696056366},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.4975493252277374},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4794924855232239},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4700694680213928},{"id":"https://openalex.org/C2777134132","wikidata":"https://www.wikidata.org/wiki/Q188638","display_name":"Mood disorders","level":3,"score":0.4622589647769928},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4357939064502716},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43091240525245667},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4185722768306732},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41447293758392334},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3733397424221039},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3507966101169586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2838905453681946},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22471469640731812},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.16011488437652588},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2015.7401546","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2015.7401546","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 8th International Conference on Biomedical Engineering and Informatics (BMEI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"No poverty","id":"https://metadata.un.org/sdg/1","score":0.6399999856948853}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1577928045","https://openalex.org/W1604476085","https://openalex.org/W1971624220","https://openalex.org/W1979089999","https://openalex.org/W1980548655","https://openalex.org/W1984344128","https://openalex.org/W2014946489","https://openalex.org/W2028776429","https://openalex.org/W2031200328","https://openalex.org/W2040191060","https://openalex.org/W2041687701","https://openalex.org/W2044575338","https://openalex.org/W2060845434","https://openalex.org/W2064010715","https://openalex.org/W2067442819","https://openalex.org/W2083381199","https://openalex.org/W2085065484","https://openalex.org/W2087258742","https://openalex.org/W2096173332","https://openalex.org/W2100671007","https://openalex.org/W2101117089","https://openalex.org/W2110541531","https://openalex.org/W2112370482","https://openalex.org/W2144001592","https://openalex.org/W2144476887","https://openalex.org/W2148512186","https://openalex.org/W2153032620","https://openalex.org/W2153562609","https://openalex.org/W2158799757","https://openalex.org/W2159011576","https://openalex.org/W2159675211","https://openalex.org/W2159816895","https://openalex.org/W2162729826","https://openalex.org/W2166240615","https://openalex.org/W2167193785","https://openalex.org/W2171520215","https://openalex.org/W6839235115"],"related_works":["https://openalex.org/W2462983098","https://openalex.org/W2132014094","https://openalex.org/W3198313168","https://openalex.org/W2390951968","https://openalex.org/W3176398639","https://openalex.org/W2059519261","https://openalex.org/W2102123970","https://openalex.org/W2414753374","https://openalex.org/W4232489090","https://openalex.org/W1992641180"],"abstract_inverted_index":{"Bipolar":[0],"is":[1,15,62],"a":[2,46,59,122],"debilitating":[3],"mood":[4],"disorder":[5,44],"characterized":[6],"by":[7],"mixed":[8],"episodes":[9],"of":[10,28,38,49,124,149],"depression":[11],"and":[12,20,26,30,55,107,114,128,136,140,157,172],"mania.":[13],"It":[14],"classified":[16],"into":[17,184],"bipolar":[18,43,100],"I":[19,101],"II":[21],"according":[22],"to":[23,73,84,90,97],"the":[24,34,41,52,56,64,85,92,95,105,112,142,170,185],"occurrences":[25],"frequencies":[27],"depressive":[29],"manic":[31],"episodes.":[32],"As":[33],"sixth":[35],"leading":[36],"cause":[37],"disability":[39],"in":[40,117],"world,":[42],"exerts":[45],"huge":[47],"amount":[48],"burden":[50],"on":[51],"patient's":[53],"family":[54],"society":[57],"as":[58],"whole.":[60],"Lithium":[61],"often":[63],"prescribed":[65],"medication;":[66],"however,":[67],"not":[68],"all":[69],"patients":[70],"are":[71],"responsive":[72],"it.":[74],"In":[75,87],"fact,":[76],"some":[77],"may":[78,181],"even":[79],"develop":[80],"adverse":[81],"drug":[82],"reactions":[83],"drug.":[86],"an":[88],"attempt":[89],"understand":[91],"mechanisms":[93],"underlying":[94,187],"response":[96],"lithium":[98,174,188],"among":[99],"patients,":[102],"we":[103],"profiled":[104],"gene":[106,134],"microRNA":[108],"expression":[109],"differences":[110],"between":[111,145,169],"good":[113,173],"poor":[115,171],"responders":[116],"peripheral":[118],"blood.":[119],"We":[120,161],"identified":[121],"number":[123],"differentially":[125],"expressed":[126],"genes":[127],"microRNAs,":[129],"determined":[130],"their":[131],"functions":[132],"using":[133],"ontology":[135],"pathway":[137],"annotation":[138],"tools,":[139],"assessed":[141],"potential":[143],"interactions":[144],"these":[146,179],"two":[147],"types":[148],"molecules":[150],"via":[151],"target":[152],"prediction":[153],"algorithms,":[154],"association":[155],"analyses,":[156],"existing":[158],"literature":[159],"evidence.":[160],"found":[162],"several":[163],"microRNA-gene":[164],"interaction":[165],"biomarkers":[166,180],"that":[167],"differ":[168],"responders.":[175],"With":[176],"future":[177],"validations,":[178],"provide":[182],"insights":[183],"mechanism":[186],"response.":[189]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
