{"id":"https://openalex.org/W1964148028","doi":"https://doi.org/10.1109/bmei.2014.7002807","title":"Tremor dependant nonlinear interaction in deep brain local field potentials of Parkinson's disease","display_name":"Tremor dependant nonlinear interaction in deep brain local field potentials of Parkinson's disease","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1964148028","doi":"https://doi.org/10.1109/bmei.2014.7002807","mag":"1964148028"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2014.7002807","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2014.7002807","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 7th International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078288462","display_name":"Zongbao Wang","orcid":"https://orcid.org/0000-0002-7399-4638"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092817","display_name":"Suzhou Institute of Biomedical Engineering and Technology","ror":"https://ror.org/00f58mx93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092817"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zongbao Wang","raw_affiliation_strings":["Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China","Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences, Suzhou, China"],"affiliations":[{"raw_affiliation_string":"Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China","institution_ids":["https://openalex.org/I4210092817","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences, Suzhou, China","institution_ids":["https://openalex.org/I4210092817","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001379996","display_name":"Yongzhi Huang","orcid":"https://orcid.org/0000-0002-2503-1589"},"institutions":[{"id":"https://openalex.org/I4210092817","display_name":"Suzhou Institute of Biomedical Engineering and Technology","ror":"https://ror.org/00f58mx93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092817"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongzhi Huang","raw_affiliation_strings":["Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China","Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences, Suzhou, China"],"affiliations":[{"raw_affiliation_string":"Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China","institution_ids":["https://openalex.org/I4210092817","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences, Suzhou, China","institution_ids":["https://openalex.org/I4210092817","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025802135","display_name":"Shouyan Wang","orcid":"https://orcid.org/0000-0002-9776-8539"},"institutions":[{"id":"https://openalex.org/I4210092817","display_name":"Suzhou Institute of Biomedical Engineering and Technology","ror":"https://ror.org/00f58mx93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092817"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shouyan Wang","raw_affiliation_strings":["Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China","Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences, Suzhou, China"],"affiliations":[{"raw_affiliation_string":"Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China","institution_ids":["https://openalex.org/I4210092817","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences, Suzhou, China","institution_ids":["https://openalex.org/I4210092817","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018134307","display_name":"Alexander L. Green","orcid":"https://orcid.org/0000-0002-7262-7297"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alex Green","raw_affiliation_strings":["John Radcliife Hospital, University of Oxford, London, UK","Functional Neurosurgery Group, John Radcliife Hospital, University of Oxford, London, UK"],"affiliations":[{"raw_affiliation_string":"John Radcliife Hospital, University of Oxford, London, UK","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Functional Neurosurgery Group, John Radcliife Hospital, University of Oxford, London, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073459233","display_name":"Tipu Z. Aziz","orcid":"https://orcid.org/0000-0001-9128-8668"},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tipu Aziz","raw_affiliation_strings":["John Radcliife Hospital, University of Oxford, London, UK","Functional Neurosurgery Group, John Radcliife Hospital, University of Oxford, London, UK"],"affiliations":[{"raw_affiliation_string":"John Radcliife Hospital, University of Oxford, London, UK","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Functional Neurosurgery Group, John Radcliife Hospital, University of Oxford, London, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031648152","display_name":"John Stein","orcid":"https://orcid.org/0000-0001-5843-8986"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Stein","raw_affiliation_strings":["John Radcliife Hospital, University of Oxford, London, UK","Functional Neurosurgery Group, John Radcliife Hospital, University of Oxford, London, UK"],"affiliations":[{"raw_affiliation_string":"John Radcliife Hospital, University of Oxford, London, UK","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Functional Neurosurgery Group, John Radcliife Hospital, University of Oxford, London, UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5078288462"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092817"],"apc_list":null,"apc_paid":null,"fwci":0.4128,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.63500272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"ps 7","issue":null,"first_page":"399","last_page":"404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/local-field-potential","display_name":"Local field potential","score":0.929263710975647},{"id":"https://openalex.org/keywords/subthalamic-nucleus","display_name":"Subthalamic nucleus","score":0.861066460609436},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"Deep brain stimulation","score":0.7885816097259521},{"id":"https://openalex.org/keywords/bispectrum","display_name":"Bispectrum","score":0.7795655727386475},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5964450836181641},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.59608393907547},{"id":"https://openalex.org/keywords/parkinsonism","display_name":"Parkinsonism","score":0.5282270908355713},{"id":"https://openalex.org/keywords/resting-state-fmri","display_name":"Resting state fMRI","score":0.5237721800804138},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.47196710109710693},{"id":"https://openalex.org/keywords/coupling","display_name":"Coupling (piping)","score":0.4570361375808716},{"id":"https://openalex.org/keywords/neurophysiology","display_name":"Neurophysiology","score":0.4473320245742798},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.41668933629989624},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3286523222923279},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2625289261341095},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2340606153011322},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.1798807680606842},{"id":"https://openalex.org/keywords/spectral-density","display_name":"Spectral density","score":0.10998654365539551},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.10293647646903992},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.09642753005027771},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.08091595768928528},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.08085313439369202}],"concepts":[{"id":"https://openalex.org/C117838684","wikidata":"https://www.wikidata.org/wiki/Q533483","display_name":"Local field potential","level":2,"score":0.929263710975647},{"id":"https://openalex.org/C2777319143","wikidata":"https://www.wikidata.org/wiki/Q2270424","display_name":"Subthalamic nucleus","level":5,"score":0.861066460609436},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.7885816097259521},{"id":"https://openalex.org/C114148568","wikidata":"https://www.wikidata.org/wiki/Q2410583","display_name":"Bispectrum","level":3,"score":0.7795655727386475},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5964450836181641},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.59608393907547},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.5282270908355713},{"id":"https://openalex.org/C66324658","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Resting state fMRI","level":2,"score":0.5237721800804138},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.47196710109710693},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.4570361375808716},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.4473320245742798},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.41668933629989624},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3286523222923279},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2625289261341095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2340606153011322},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1798807680606842},{"id":"https://openalex.org/C168110828","wikidata":"https://www.wikidata.org/wiki/Q1331626","display_name":"Spectral density","level":2,"score":0.10998654365539551},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10293647646903992},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09642753005027771},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.08091595768928528},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.08085313439369202},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2014.7002807","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2014.7002807","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 7th International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1972879677","https://openalex.org/W1974135658","https://openalex.org/W1982475930","https://openalex.org/W2018388266","https://openalex.org/W2024383241","https://openalex.org/W2034693484","https://openalex.org/W2040821740","https://openalex.org/W2051004303","https://openalex.org/W2056849177","https://openalex.org/W2062918171","https://openalex.org/W2083749685","https://openalex.org/W2083936577","https://openalex.org/W2094679226","https://openalex.org/W2095423286","https://openalex.org/W2103908673","https://openalex.org/W2125480067","https://openalex.org/W2125948089","https://openalex.org/W2126201966","https://openalex.org/W2126718345","https://openalex.org/W2143685192","https://openalex.org/W2161682285","https://openalex.org/W3122507959"],"related_works":["https://openalex.org/W2167683893","https://openalex.org/W20470332","https://openalex.org/W2022280818","https://openalex.org/W2505879770","https://openalex.org/W2901701120","https://openalex.org/W2042581695","https://openalex.org/W1977510211","https://openalex.org/W2330101293","https://openalex.org/W2073248892","https://openalex.org/W2316743065"],"abstract_inverted_index":{"Nonlinear":[0],"interaction":[1],"between":[2,128],"neural":[3,129],"oscillations":[4,130],"may":[5],"be":[6,136],"a":[7],"biomarker":[8],"for":[9],"closed-loop":[10],"deep":[11,153],"brain":[12,154],"stimulation":[13,155],"(DBS)":[14],"in":[15,73,87,94,102,108,113,142],"Parkinson's":[16,143],"disease.":[17],"Bispectral":[18],"analysis":[19,35],"is":[20],"an":[21],"effective":[22],"tool":[23],"to":[24,36,138,148],"detect":[25],"quadratic":[26],"phase":[27,69],"coupling.":[28],"In":[29],"this":[30],"paper":[31],"we":[32],"applied":[33],"bispectral":[34,83],"local":[37,132],"field":[38,133],"potentials":[39,134],"(LFPs)":[40],"recorded":[41],"from":[42],"Parkinsonism":[43],"patients'":[44],"subthalamic":[45],"nucleus":[46],"(STN)":[47],"during":[48],"tremor":[49,95],"and":[50,90,120,145],"resting":[51,103,109],"states.":[52],"The":[53,122],"significance":[54],"of":[55,117,124,131,151],"the":[56,77,91,106,149],"coupling":[57,78],"was":[58],"statistically":[59],"tested":[60],"using":[61],"bispectrum":[62],"estimation":[63],"with":[64],"surrogate":[65],"data":[66],"approaches.":[67],"Strong":[68],"couplings":[70],"were":[71],"found":[72],"both":[74,88],"states,":[75],"whereas":[76],"frequencies":[79],"varied.":[80],"There":[81],"are":[82,97],"peaks":[84,112],"around":[85],"3-6Hz":[86],"states":[89,141],"peak":[92],"amplitudes":[93],"state":[96,110],"twice":[98],"larger":[99],"than":[100],"those":[101],"state,":[104],"while":[105],"bispectra":[107],"shows":[111],"narrow":[114],"frequency":[115],"bands":[116],"7-9Hz,":[118],"10-12Hz":[119],"15-17Hz.":[121],"measure":[123],"these":[125],"nonlinear":[126],"interactions":[127],"can":[135],"used":[137],"distinguish":[139],"pathological":[140],"disease":[144],"could":[146],"contribute":[147],"development":[150],"intelligent":[152],"strategies.":[156]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}