{"id":"https://openalex.org/W2036334276","doi":"https://doi.org/10.1109/bmei.2013.6746989","title":"Epigenetic profiling of DNA methylation changes associated with chronic alcohol consumption: A 12-year follow-up study","display_name":"Epigenetic profiling of DNA methylation changes associated with chronic alcohol consumption: A 12-year follow-up study","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2036334276","doi":"https://doi.org/10.1109/bmei.2013.6746989","mag":"2036334276"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2013.6746989","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2013.6746989","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 6th International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102950025","display_name":"Julia Weng","orcid":"https://orcid.org/0000-0003-0127-0945"},"institutions":[{"id":"https://openalex.org/I99908691","display_name":"Yuan Ze University","ror":"https://ror.org/01fv1ds98","country_code":"TW","type":"education","lineage":["https://openalex.org/I99908691"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Julia Tzu-Ya Weng","raw_affiliation_strings":["Department of Computer Science & Engineering, Yuan Ze University, Chung-Li, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science & Engineering, Yuan Ze University, Chung-Li, Taiwan","institution_ids":["https://openalex.org/I99908691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111534556","display_name":"Lawrence Shih\u2010Hsin Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210136969","display_name":"Institute of Molecular Biology, Academia Sinica","ror":"https://ror.org/047sbcx71","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Lawrence Shih-Hsin Wu","raw_affiliation_strings":["Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210136969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769173","display_name":"Yicheng Chen","orcid":"https://orcid.org/0000-0002-7255-2176"},"institutions":[{"id":"https://openalex.org/I189772984","display_name":"Tzu Chi University","ror":"https://ror.org/04ss1bw11","country_code":"TW","type":"education","lineage":["https://openalex.org/I189772984"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Cheng Chen","raw_affiliation_strings":["Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan","institution_ids":["https://openalex.org/I189772984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103111247","display_name":"Paul Wei\u2010Che Hsu","orcid":"https://orcid.org/0000-0001-9365-9565"},"institutions":[{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Paul Wei-Che Hsu","raw_affiliation_strings":["Department of Psychiatry, Mackay Memorial Hospital, New Taipei City, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Mackay Memorial Hospital, New Taipei City, Taiwan","institution_ids":["https://openalex.org/I2802753785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080257216","display_name":"Chau\u2010Shoun Lee","orcid":"https://orcid.org/0000-0002-1509-4340"},"institutions":[{"id":"https://openalex.org/I107470533","display_name":"Tamkang University","ror":"https://ror.org/04tft4718","country_code":"TW","type":"education","lineage":["https://openalex.org/I107470533"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chau-Shoun Lee","raw_affiliation_strings":["Department of Computer Science & Information Engineering, Tamkang University, New Taipei City, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science & Information Engineering, Tamkang University, New Taipei City, Taiwan","institution_ids":["https://openalex.org/I107470533"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112897132","display_name":"Andrew T. A. Cheng","orcid":null},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Andrew T. A. Cheng","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210096666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5102950025"],"corresponding_institution_ids":["https://openalex.org/I99908691"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07771478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":null,"first_page":"471","last_page":"476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11464","display_name":"Homelessness and Social Issues","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8106033802032471},{"id":"https://openalex.org/keywords/epigenome","display_name":"Epigenome","score":0.7758454084396362},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.7260562181472778},{"id":"https://openalex.org/keywords/epigenomics","display_name":"Epigenomics","score":0.7226722836494446},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.5611243844032288},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5176732540130615},{"id":"https://openalex.org/keywords/methylated-dna-immunoprecipitation","display_name":"Methylated DNA immunoprecipitation","score":0.511993944644928},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4167528450489044},{"id":"https://openalex.org/keywords/alcohol","display_name":"Alcohol","score":0.4117972254753113},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4099138379096985},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4051372706890106},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12668964266777039}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.8106033802032471},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.7758454084396362},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7260562181472778},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.7226722836494446},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5611243844032288},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5176732540130615},{"id":"https://openalex.org/C116114238","wikidata":"https://www.wikidata.org/wiki/Q6823960","display_name":"Methylated DNA immunoprecipitation","level":5,"score":0.511993944644928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4167528450489044},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.4117972254753113},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4099138379096985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4051372706890106},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12668964266777039},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bmei.2013.6746989","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2013.6746989","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 6th International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"},{"id":"pmh:oai:tkuir.lib.tku.edu.tw:987654321/98143","is_oa":false,"landing_page_url":"https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/98143","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8700000047683716,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1544906050","https://openalex.org/W1914773349","https://openalex.org/W1955776944","https://openalex.org/W1971175228","https://openalex.org/W1972493675","https://openalex.org/W2000305599","https://openalex.org/W2002006123","https://openalex.org/W2003005689","https://openalex.org/W2003402014","https://openalex.org/W2006316372","https://openalex.org/W2006499212","https://openalex.org/W2008881692","https://openalex.org/W2024961454","https://openalex.org/W2034703630","https://openalex.org/W2034826919","https://openalex.org/W2035697450","https://openalex.org/W2048070034","https://openalex.org/W2055423122","https://openalex.org/W2059723753","https://openalex.org/W2060342626","https://openalex.org/W2071138844","https://openalex.org/W2073123191","https://openalex.org/W2079804491","https://openalex.org/W2082284136","https://openalex.org/W2092075890","https://openalex.org/W2097375063","https://openalex.org/W2100628640","https://openalex.org/W2113494736","https://openalex.org/W2124985425","https://openalex.org/W2135079388","https://openalex.org/W2138763987","https://openalex.org/W2139496188","https://openalex.org/W2141699093","https://openalex.org/W2144362367","https://openalex.org/W2144950894","https://openalex.org/W2145377013","https://openalex.org/W2149105021","https://openalex.org/W2169486780","https://openalex.org/W2170969817","https://openalex.org/W2313075543","https://openalex.org/W4237120149","https://openalex.org/W6639832414","https://openalex.org/W6677353398"],"related_works":["https://openalex.org/W2424092526","https://openalex.org/W2507790420","https://openalex.org/W2212710981","https://openalex.org/W2795223073","https://openalex.org/W4200376839","https://openalex.org/W2151543286","https://openalex.org/W2418239907","https://openalex.org/W2142890267","https://openalex.org/W4280600268","https://openalex.org/W2474086683"],"abstract_inverted_index":{"Alcoholism":[0],"has":[1,18],"always":[2],"been":[3,20,31],"a":[4,240],"major":[5,41],"public":[6],"health":[7,37],"concern":[8],"in":[9,12,140,143,172,186,207],"Taiwan,":[10],"especially":[11],"the":[13,35,47,54,61,97,103,134,144,167,173,180,187,190,234],"aboriginal":[14,42,69],"communities.":[15],"DNA":[16,87,141],"methylation":[17,142,191],"recently":[19],"found":[21,197],"to":[22,52,198],"be":[23],"associated":[24,228],"with":[25,86,200,229],"alcoholism.":[26],"Since":[27],"1986,":[28],"we":[29,50],"have":[30,127],"following":[32],"up":[33,77],"on":[34,60,67,117],"mental":[36],"conditions":[38],"of":[39,44,56,182,193,249],"four":[40],"peoples":[43],"Taiwan.":[45],"In":[46],"current":[48],"study,":[49],"attempted":[51],"profile":[53],"effect":[55],"chronic":[57,230],"alcohol":[58,118,201,231],"exposure":[59],"epigenome.":[62],"Clinical":[63],"interviews":[64],"were":[65,196],"performed":[66],"993":[68],"people":[70],"at":[71,89,111,147,233],"phase":[72,79,83,104,112,120],"1":[73,105],"(1986),":[74],"and":[75,82,92,114,123,150,157,175,210,220],"followed":[76],"through":[78],"2":[80,91,113,149],"(1990\u20131992),":[81],"3":[84,121],"(2003\u20132009)":[85],"preparations":[88],"phases":[90,148],"3.":[93,151],"Selected":[94],"individuals":[95],"for":[96],"present":[98],"study":[99,135,223],"included":[100],"males":[101],"from":[102],"normal":[106,110],"cohort":[107],"who":[108],"remained":[109],"became":[115],"dependent":[116],"by":[119],"(n=10)":[122],"control":[124,174],"subjects":[125],"that":[126,155,162,226,244],"not":[128],"had":[129],"any":[130],"drinking":[131],"problems":[132],"throughout":[133],"(n=10).":[136],"We":[137],"assessed":[138],"changes":[139],"blood":[145],"collected":[146],"Preliminary":[152],"data":[153],"show":[154],"201":[156],"254":[158],"genes":[159,183,195,205,217,225],"contain":[160],"sites":[161],"are":[163,227],"differentially":[164,184],"methylated":[165,185],"between":[166],"two":[168],"collection":[169],"time":[170],"points":[171],"case":[176,188],"subjects,":[177],"respectively.":[178],"Among":[179],"list":[181],"group,":[189],"levels":[192],"6":[194],"correlate":[199],"consumption.":[202],"These":[203],"include":[204],"involved":[206],"neurogenesis":[208],"(NPDC1)":[209],"inflammation":[211],"(HERC5)":[212],"as":[213,215],"well":[214],"alcoholism-associated":[216],"ADCY9,":[218],"CKM,":[219],"PHOX2A.":[221],"Our":[222],"identified":[224],"consumption":[232],"epigenetic":[235],"level.":[236],"The":[237],"results":[238],"offer":[239],"comprehensive":[241],"epigenomic":[242],"map":[243],"helps":[245],"enhance":[246],"our":[247],"understanding":[248],"alcohol-induced":[250],"damages.":[251]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}