{"id":"https://openalex.org/W2005750714","doi":"https://doi.org/10.1109/bmei.2012.6513124","title":"Predicting binding affinity using differential evolution","display_name":"Predicting binding affinity using differential evolution","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2005750714","doi":"https://doi.org/10.1109/bmei.2012.6513124","mag":"2005750714"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2012.6513124","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2012.6513124","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 5th International Conference on BioMedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033526845","display_name":"Chunyu Cong","orcid":null},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunyu Cong","raw_affiliation_strings":["School of Computer and Information Technology Northeast Normal University, NENU Changchun, 130117 China","Sch. of Comput. & Inf. Technol., Northeast Normal Univ., Changchun, China"],"affiliations":[{"raw_affiliation_string":"School of Computer and Information Technology Northeast Normal University, NENU Changchun, 130117 China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"Sch. of Comput. & Inf. Technol., Northeast Normal Univ., Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101612132","display_name":"Pingping Sun","orcid":"https://orcid.org/0000-0001-7626-8167"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pingping Sun","raw_affiliation_strings":["School of Computer and Information Technology Northeast Normal University, NENU Changchun, 130117 China","Sch. of Comput. & Inf. Technol., Northeast Normal Univ., Changchun, China"],"affiliations":[{"raw_affiliation_string":"School of Computer and Information Technology Northeast Normal University, NENU Changchun, 130117 China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"Sch. of Comput. & Inf. Technol., Northeast Normal Univ., Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038788906","display_name":"Zhiqiang Ma","orcid":"https://orcid.org/0000-0002-1922-6283"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqiang Ma","raw_affiliation_strings":["School of Computer and Information Technology Northeast Normal University, NENU Changchun, 130117 China","Sch. of Comput. & Inf. Technol., Northeast Normal Univ., Changchun, China"],"affiliations":[{"raw_affiliation_string":"School of Computer and Information Technology Northeast Normal University, NENU Changchun, 130117 China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"Sch. of Comput. & Inf. Technol., Northeast Normal Univ., Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033526845"],"corresponding_institution_ids":["https://openalex.org/I184983240"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06658318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"906","last_page":"909"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"Major histocompatibility complex","score":0.7711158394813538},{"id":"https://openalex.org/keywords/precondition","display_name":"Precondition","score":0.705175518989563},{"id":"https://openalex.org/keywords/antigen-processing","display_name":"Antigen processing","score":0.5694624185562134},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5387817621231079},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.537165641784668},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5264402627944946},{"id":"https://openalex.org/keywords/class","display_name":"Class (philosophy)","score":0.47887176275253296},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"Antigen presentation","score":0.4618128538131714},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.4512828290462494},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.3995189964771271},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3560931980609894},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3184162378311157},{"id":"https://openalex.org/keywords/t-cell","display_name":"T cell","score":0.31674519181251526},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2952967882156372},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.2949601411819458},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.08176901936531067}],"concepts":[{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.7711158394813538},{"id":"https://openalex.org/C192465680","wikidata":"https://www.wikidata.org/wiki/Q1413450","display_name":"Precondition","level":2,"score":0.705175518989563},{"id":"https://openalex.org/C108249834","wikidata":"https://www.wikidata.org/wiki/Q3922363","display_name":"Antigen processing","level":5,"score":0.5694624185562134},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5387817621231079},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.537165641784668},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5264402627944946},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.47887176275253296},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.4618128538131714},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.4512828290462494},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3995189964771271},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3560931980609894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3184162378311157},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.31674519181251526},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2952967882156372},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2949601411819458},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.08176901936531067}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2012.6513124","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2012.6513124","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 5th International Conference on BioMedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W30379650","https://openalex.org/W1595159159","https://openalex.org/W1596377987","https://openalex.org/W1852635481","https://openalex.org/W1991461541","https://openalex.org/W1991490962","https://openalex.org/W2002237479","https://openalex.org/W2039585266","https://openalex.org/W2081400647","https://openalex.org/W2099500226","https://openalex.org/W2101423456","https://openalex.org/W2103498243","https://openalex.org/W2114957284","https://openalex.org/W2135455279","https://openalex.org/W2145795099","https://openalex.org/W2149350146","https://openalex.org/W2160583217","https://openalex.org/W2439454780","https://openalex.org/W6718674862"],"related_works":["https://openalex.org/W2107554173","https://openalex.org/W2462657557","https://openalex.org/W2023967363","https://openalex.org/W2041638315","https://openalex.org/W4244317160","https://openalex.org/W2409344746","https://openalex.org/W1991142812","https://openalex.org/W2168513984","https://openalex.org/W1592776416","https://openalex.org/W2058264657"],"abstract_inverted_index":{"During":[0],"the":[1,6,9,22,39,54,58,67,72,100,110,118],"processing":[2],"and":[3,13,64,71,89,98,107],"presentation":[4],"of":[5,34,57,69,74,103],"exogenous":[7],"antigen":[8],"binding":[10,40],"between":[11],"antigens":[12],"major":[14],"histocompatibility":[15],"complex":[16],"class":[17],"II":[18],"molecules":[19],"(MHC-II)":[20],"is":[21,62,83,94],"precondition":[23],"for":[24,66],"activating":[25],"helper":[26],"T":[27],"cell":[28],"to":[29,52,96],"response.":[30],"For":[31],"one":[32],"kind":[33],"given":[35],"MHC-II":[36,104],"molecules,":[37],"if":[38],"peptide":[41],"can":[42,49],"be":[43],"predicted":[44],"precisely,":[45],"not":[46],"only":[47],"it":[48],"help":[50],"us":[51],"understand":[53],"basic":[55],"principle":[56],"immune":[59],"but":[60],"also":[61],"useful":[63],"significant":[65],"development":[68],"vaccine":[70],"cure":[73],"autoimmune":[75],"diseases.":[76],"In":[77],"this":[78,123],"paper":[79,124],"a":[80],"method":[81],"which":[82],"composed":[84],"by":[85],"Differential":[86],"Evolution":[87],"(DE)":[88],"position-specific":[90],"scoring":[91],"matrix":[92],"(PSSM)":[93],"used":[95],"train":[97],"analyze":[99],"14":[101],"kinds":[102],"allele's":[105],"data":[106],"set":[108],"up":[109],"prediction":[111],"models":[112,117],"separately.":[113],"Comparing":[114],"with":[115],"other":[116],"model":[119],"called":[120],"DE-PSSM":[121],"in":[122],"performs":[125],"better.":[126]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}