{"id":"https://openalex.org/W1964481341","doi":"https://doi.org/10.1109/bmei.2011.6098715","title":"Extracelluar potassium ions play important roles in the selectivity of mutant KcsA channel","display_name":"Extracelluar potassium ions play important roles in the selectivity of mutant KcsA channel","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W1964481341","doi":"https://doi.org/10.1109/bmei.2011.6098715","mag":"1964481341"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2011.6098715","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2011.6098715","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 4th International Conference on Biomedical Engineering and Informatics (BMEI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100623687","display_name":"Yuzhi Liu","orcid":"https://orcid.org/0000-0001-7238-4224"},"institutions":[{"id":"https://openalex.org/I90090648","display_name":"Shijiazhuang Tiedao University","ror":"https://ror.org/022e9e065","country_code":"CN","type":"education","lineage":["https://openalex.org/I90090648"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuzhi Liu","raw_affiliation_strings":["School of Electrical and Electronics Engineering, Shijiazhuang Tiedao University, Shijiazhuang, China","School of Electrical and Electronics Engineering, Shijiazhuang Tiedao University, 050043, Shijiazhuang, China"],"affiliations":[{"raw_affiliation_string":"School of Electrical and Electronics Engineering, Shijiazhuang Tiedao University, Shijiazhuang, China","institution_ids":["https://openalex.org/I90090648"]},{"raw_affiliation_string":"School of Electrical and Electronics Engineering, Shijiazhuang Tiedao University, 050043, Shijiazhuang, China","institution_ids":["https://openalex.org/I90090648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083718913","display_name":"Hailong An","orcid":"https://orcid.org/0000-0001-7947-357X"},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hailong An","raw_affiliation_strings":["School of Sciences, Hebei University of Technology, Tianjin, China","School of Sciences, Hebei University of Technology, 300130, Tianjin, China"],"affiliations":[{"raw_affiliation_string":"School of Sciences, Hebei University of Technology, Tianjin, China","institution_ids":["https://openalex.org/I184843921"]},{"raw_affiliation_string":"School of Sciences, Hebei University of Technology, 300130, Tianjin, China","institution_ids":["https://openalex.org/I184843921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003707455","display_name":"Suhua Zhang","orcid":"https://orcid.org/0000-0001-7215-4613"},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suhua Zhang","raw_affiliation_strings":["School of Sciences, Hebei University of Technology, Tianjin, China","School of Sciences, Hebei University of Technology, 300130, Tianjin, China"],"affiliations":[{"raw_affiliation_string":"School of Sciences, Hebei University of Technology, Tianjin, China","institution_ids":["https://openalex.org/I184843921"]},{"raw_affiliation_string":"School of Sciences, Hebei University of Technology, 300130, Tianjin, China","institution_ids":["https://openalex.org/I184843921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100374865","display_name":"Junwei Li","orcid":"https://orcid.org/0000-0002-1724-4752"},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junwei Li","raw_affiliation_strings":["School of Sciences, Hebei University of Technology, Tianjin, China","School of Sciences, Hebei University of Technology, 300130, Tianjin, China"],"affiliations":[{"raw_affiliation_string":"School of Sciences, Hebei University of Technology, Tianjin, China","institution_ids":["https://openalex.org/I184843921"]},{"raw_affiliation_string":"School of Sciences, Hebei University of Technology, 300130, Tianjin, China","institution_ids":["https://openalex.org/I184843921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101564619","display_name":"Yong Zhan","orcid":"https://orcid.org/0000-0002-2679-7703"},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Zhan","raw_affiliation_strings":["School of Sciences, Hebei University of Technology, Tianjin, China","School of Sciences, Hebei University of Technology, 300130, Tianjin, China"],"affiliations":[{"raw_affiliation_string":"School of Sciences, Hebei University of Technology, Tianjin, China","institution_ids":["https://openalex.org/I184843921"]},{"raw_affiliation_string":"School of Sciences, Hebei University of Technology, 300130, Tianjin, China","institution_ids":["https://openalex.org/I184843921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100623687"],"corresponding_institution_ids":["https://openalex.org/I90090648"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05356723,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"280","issue":null,"first_page":"1844","last_page":"1847"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kcsa-potassium-channel","display_name":"KcsA potassium channel","score":0.9163126349449158},{"id":"https://openalex.org/keywords/potassium-channel","display_name":"Potassium channel","score":0.6435496211051941},{"id":"https://openalex.org/keywords/selectivity","display_name":"Selectivity","score":0.5188797116279602},{"id":"https://openalex.org/keywords/ion","display_name":"Ion","score":0.45981061458587646},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.42156392335891724},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.39626461267471313},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.323012113571167},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.21543550491333008},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1354394257068634},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12567231059074402},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.09991365671157837}],"concepts":[{"id":"https://openalex.org/C45516822","wikidata":"https://www.wikidata.org/wiki/Q6382011","display_name":"KcsA potassium channel","level":4,"score":0.9163126349449158},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.6435496211051941},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.5188797116279602},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.45981061458587646},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42156392335891724},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.39626461267471313},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.323012113571167},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.21543550491333008},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1354394257068634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12567231059074402},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09991365671157837},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2011.6098715","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2011.6098715","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 4th International Conference on Biomedical Engineering and Informatics (BMEI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.7300000190734863}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1972343863","https://openalex.org/W1991033228","https://openalex.org/W2022120527","https://openalex.org/W2030133331","https://openalex.org/W2033755632","https://openalex.org/W2064239407","https://openalex.org/W2094349878","https://openalex.org/W2107320528","https://openalex.org/W2109258309","https://openalex.org/W2132141632","https://openalex.org/W2143070723","https://openalex.org/W2146152598","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W591522727","https://openalex.org/W2950877693","https://openalex.org/W3168586120","https://openalex.org/W1964758210","https://openalex.org/W2086437923","https://openalex.org/W1999929223","https://openalex.org/W2019461599","https://openalex.org/W2379222240","https://openalex.org/W1980131439","https://openalex.org/W2115458056"],"abstract_inverted_index":{"Potassium":[0],"channels":[1,49,104],"are":[2,165],"exquisitely":[3],"selective,":[4],"allowing":[5],"K":[6,45],"<sup":[7,21,26,46,76,84,133,145,158],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[8,22,27,47,77,85,134,146,159],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">+</sup>":[9,23,28,48,86,147,160],"to":[10,50,69],"cross":[11],"cell":[12],"membranes":[13],"while":[14],"blocking":[15],"other":[16],"ions,":[17],"such":[18],"as":[19],"Na":[20],"and":[24,53,65,81,113,139],"Cs":[25],".":[29],"It":[30,119],"is":[31,39,120,178],"now":[32],"universally":[33],"accepted":[34],"that":[35,43,92,123,175],"the":[36,40,61,66,71,93,99,102,108,111,114,121,125,168,176,182,187],"selectivity":[37,72,126,177],"filter":[38,115],"functional":[41,63],"unit":[42],"allows":[44],"distinguish":[51],"potassium":[52,95,128,138,153],"sodium":[54,140],"ions.":[55],"In":[56],"this":[57],"paper,":[58],"we":[59],"adopted":[60],"density":[62],"theory":[64],"Brownian":[67],"dynamics":[68],"study":[70],"mechanism":[73],"of":[74,101,116,127,181,190],"KcsA":[75,132],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">D-Ala77</sup>":[78,135],"in":[79,142,155],"low":[80,143],"high":[82,156],"[K":[83,144,157],"]":[87,148,161],"conditions.":[88,162],"The":[89,131,163,171],"results":[90,164,172],"suggest":[91],"extracelluar":[94],"ions":[96,112,129,141,154],"can":[97,106,136],"change":[98],"conformation":[100],"ion":[103,117],"which":[105],"affect":[107],"interaction":[109,122],"between":[110],"channels.":[118,130],"determines":[124],"permeate":[137,152],"conditions,":[149],"but":[150],"only":[151,186],"consistent":[166],"with":[167],"experimental":[169],"data.":[170],"may":[173],"demonstrate":[174],"a":[179],"property":[180],"channel":[183],"structure,":[184],"not":[185],"consensus":[188],"sequence":[189],"amino.":[191]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
