{"id":"https://openalex.org/W1967806325","doi":"https://doi.org/10.1109/bmei.2011.6098558","title":"The effects of mechanical stimulation on proliferation and CTGF expression of human lung fibroblast","display_name":"The effects of mechanical stimulation on proliferation and CTGF expression of human lung fibroblast","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W1967806325","doi":"https://doi.org/10.1109/bmei.2011.6098558","mag":"1967806325"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2011.6098558","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2011.6098558","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 4th International Conference on Biomedical Engineering and Informatics (BMEI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100642262","display_name":"Guohui Wang","orcid":"https://orcid.org/0000-0003-1908-3945"},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guohui Wang","raw_affiliation_strings":["College of pharmacy and Biological Science, Weifang Medical University, Weifang, China","College of pharmacy and Biological Science Weifang Medical, University Weifang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of pharmacy and Biological Science, Weifang Medical University, Weifang, China","institution_ids":["https://openalex.org/I117331123"]},{"raw_affiliation_string":"College of pharmacy and Biological Science Weifang Medical, University Weifang, China","institution_ids":["https://openalex.org/I117331123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052511096","display_name":"Yongpeng Xie","orcid":"https://orcid.org/0000-0001-5787-5463"},"institutions":[{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongpeng Xie","raw_affiliation_strings":["Emergency Department, Lianyungang first people's hospital, Lianyungang, China","Emergency department, Lianyungang first people's, hospital, Lianyungang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Department, Lianyungang first people's hospital, Lianyungang, China","institution_ids":["https://openalex.org/I4210129127"]},{"raw_affiliation_string":"Emergency department, Lianyungang first people's, hospital, Lianyungang, China","institution_ids":["https://openalex.org/I4210129127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045363093","display_name":"Dan Shi","orcid":"https://orcid.org/0000-0003-4661-0464"},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]},{"id":"https://openalex.org/I49232843","display_name":"Changchun University","ror":"https://ror.org/02an57k10","country_code":"CN","type":"education","lineage":["https://openalex.org/I49232843"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Shi","raw_affiliation_strings":["Emergency Department, Changchun university hospital of traditional Chinese medicine, Changchun, China","Emergency department, Changchun university, hospital of traditional, Chinese medicine, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Department, Changchun university hospital of traditional Chinese medicine, Changchun, China","institution_ids":["https://openalex.org/I4210128075"]},{"raw_affiliation_string":"Emergency department, Changchun university, hospital of traditional, Chinese medicine, Changchun, China","institution_ids":["https://openalex.org/I49232843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114626621","display_name":"Nan Zhang","orcid":"https://orcid.org/0000-0002-2375-3051"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Zhang","raw_affiliation_strings":["Emergency Department, first hospital of Jilin university, Changchun, China","Emergency Department, The First Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Department, first hospital of Jilin university, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210125137"]},{"raw_affiliation_string":"Emergency Department, The First Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210125137"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9941,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.76032835,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"25","issue":null,"first_page":"1537","last_page":"1540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.9193000197410583,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ctgf","display_name":"CTGF","score":0.9756911993026733},{"id":"https://openalex.org/keywords/connective-tissue","display_name":"Connective tissue","score":0.778579831123352},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.6495890021324158},{"id":"https://openalex.org/keywords/fibroblast","display_name":"Fibroblast","score":0.6463778018951416},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"Flow cytometry","score":0.6277018785476685},{"id":"https://openalex.org/keywords/growth-factor","display_name":"Growth factor","score":0.5757308006286621},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.46983572840690613},{"id":"https://openalex.org/keywords/fibroblast-growth-factor","display_name":"Fibroblast growth factor","score":0.45931604504585266},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.4218546450138092},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.34892046451568604},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2961803078651428},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29514485597610474},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.27738121151924133},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2281665802001953},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.22076639533042908},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.21651878952980042},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.13400229811668396},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.061534613370895386}],"concepts":[{"id":"https://openalex.org/C2780631158","wikidata":"https://www.wikidata.org/wiki/Q14907752","display_name":"CTGF","level":4,"score":0.9756911993026733},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.778579831123352},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6495890021324158},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.6463778018951416},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6277018785476685},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5757308006286621},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46983572840690613},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.45931604504585266},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4218546450138092},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34892046451568604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2961803078651428},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29514485597610474},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27738121151924133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2281665802001953},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22076639533042908},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21651878952980042},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13400229811668396},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.061534613370895386},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2011.6098558","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2011.6098558","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 4th International Conference on Biomedical Engineering and Informatics (BMEI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W601922241","https://openalex.org/W2065836836","https://openalex.org/W2140103530","https://openalex.org/W2140462742","https://openalex.org/W2181944258","https://openalex.org/W2388822515","https://openalex.org/W2410773019","https://openalex.org/W3146580489","https://openalex.org/W6680570952","https://openalex.org/W6685739635"],"related_works":["https://openalex.org/W2048544033","https://openalex.org/W2355861542","https://openalex.org/W2394095643","https://openalex.org/W2376122532","https://openalex.org/W2354843001","https://openalex.org/W2377884670","https://openalex.org/W2393037898","https://openalex.org/W2348386651","https://openalex.org/W1982819764","https://openalex.org/W1984587649"],"abstract_inverted_index":{"To":[0],"understand":[1],"the":[2,21,57,74,78,85,91,95,101,119],"effect":[3],"of":[4,16,55,71,88,97,125],"mechanical":[5,113],"stimulation":[6,114],"on":[7],"proliferation":[8,45,96,120],"and":[9,32,48,69,81,99,106,122],"connective":[10],"tissue":[11],"growth":[12],"factor":[13],"(CTGF)":[14],"expression":[15,59,87,103,124],"human":[17],"lung":[18,126],"fibroblast":[19],"(MRC-5),":[20],"cells":[22],"were":[23],"subjected":[24],"to":[25],"cyclic":[26],"stretch":[27,76,93],"regimens":[28],"(sine":[29],"wave,":[30],"5%":[31,75],"10%":[33,92],"elongation":[34],"amplitude,":[35],"0.2Hz,":[36],"48h":[37,54,70,107],"duration)":[38],"by":[39,50,62],"FX-4000":[40],"Tension":[41],"System.":[42],"The":[43],"MRC-5":[44,98],"was":[46,60],"examined":[47],"analyzed":[49],"flow":[51],"cytometry":[52],"following":[53,65],"stretch,":[56],"CTGF":[58,86,102,123],"detected":[61],"ELISA":[63],"method":[64],"12h,":[66],"24h,":[67],"36h,":[68],"stretch.":[72],"Results:":[73],"promoted":[77],"proliferate":[79],"activity":[80,121],"did":[82],"not":[83],"affect":[84],"MRC-5;":[89],"however,":[90],"inhibited":[94],"increased":[100],"at":[104],"36h":[105],"(P<;0.05).":[108],"It":[109],"is":[110],"concluded":[111],"that":[112],"play":[115],"important":[116],"role":[117],"in":[118],"fibroblast.":[127]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}