{"id":"https://openalex.org/W2034711338","doi":"https://doi.org/10.1109/bmei.2011.6098549","title":"Designing a nerve tissue scaffold of tunable stiffness from natural biomaterials","display_name":"Designing a nerve tissue scaffold of tunable stiffness from natural biomaterials","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W2034711338","doi":"https://doi.org/10.1109/bmei.2011.6098549","mag":"2034711338"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2011.6098549","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2011.6098549","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 4th International Conference on Biomedical Engineering and Informatics (BMEI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025827552","display_name":"Chad Tuchek","orcid":null},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chad Tuchek","raw_affiliation_strings":["Interdisciplinary Engineering, Purdue University, West Lafayette, IN, USA","Interdisciplinary Engineering, Purdue University, West Lafayette, IN USA"],"affiliations":[{"raw_affiliation_string":"Interdisciplinary Engineering, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Interdisciplinary Engineering, Purdue University, West Lafayette, IN USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060699579","display_name":"Todd Rickett","orcid":null},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]},{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Rickett","raw_affiliation_strings":["Indiana University School of Medicine, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA","Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I592451","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA#TAB#","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063953835","display_name":"Sherry L. Voytik\u2010Harbin","orcid":"https://orcid.org/0000-0001-6210-3724"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherry Voytik-Harbin","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA","Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA#TAB#","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058022813","display_name":"Riyi Shi","orcid":"https://orcid.org/0000-0002-7297-9428"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Riyi Shi","raw_affiliation_strings":["Department of Basic Medical Sciences, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA","Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA#TAB#","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025827552"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07423077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1201","last_page":"1203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11737","display_name":"Advanced Materials and Mechanics","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9847999811172485,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genipin","display_name":"Genipin","score":0.9755470752716064},{"id":"https://openalex.org/keywords/chitosan","display_name":"Chitosan","score":0.7327227592468262},{"id":"https://openalex.org/keywords/scaffold","display_name":"Scaffold","score":0.7218419909477234},{"id":"https://openalex.org/keywords/regeneration","display_name":"Regeneration (biology)","score":0.7112256288528442},{"id":"https://openalex.org/keywords/biomaterial","display_name":"Biomaterial","score":0.6605474948883057},{"id":"https://openalex.org/keywords/self-healing-hydrogels","display_name":"Self-healing hydrogels","score":0.6403365135192871},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"Tissue engineering","score":0.6109626889228821},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5720680356025696},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5039066672325134},{"id":"https://openalex.org/keywords/biopolymer","display_name":"Biopolymer","score":0.5020058155059814},{"id":"https://openalex.org/keywords/neurite","display_name":"Neurite","score":0.46382609009742737},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"Regenerative medicine","score":0.45439863204956055},{"id":"https://openalex.org/keywords/neural-tissue-engineering","display_name":"Neural tissue engineering","score":0.41185200214385986},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3658794164657593},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.28890007734298706},{"id":"https://openalex.org/keywords/polymer","display_name":"Polymer","score":0.13271674513816833},{"id":"https://openalex.org/keywords/polymer-chemistry","display_name":"Polymer chemistry","score":0.12939295172691345},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.1261732280254364},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.12348756194114685},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.10143259167671204},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.09742516279220581},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.06471514701843262},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.06318533420562744}],"concepts":[{"id":"https://openalex.org/C2781438746","wikidata":"https://www.wikidata.org/wiki/Q1463401","display_name":"Genipin","level":3,"score":0.9755470752716064},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.7327227592468262},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.7218419909477234},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.7112256288528442},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.6605474948883057},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.6403365135192871},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.6109626889228821},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5720680356025696},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5039066672325134},{"id":"https://openalex.org/C2778636629","wikidata":"https://www.wikidata.org/wiki/Q422649","display_name":"Biopolymer","level":3,"score":0.5020058155059814},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.46382609009742737},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.45439863204956055},{"id":"https://openalex.org/C187761678","wikidata":"https://www.wikidata.org/wiki/Q7002068","display_name":"Neural tissue engineering","level":3,"score":0.41185200214385986},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3658794164657593},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28890007734298706},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.13271674513816833},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.12939295172691345},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1261732280254364},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.12348756194114685},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10143259167671204},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09742516279220581},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06471514701843262},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06318533420562744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2011.6098549","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2011.6098549","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 4th International Conference on Biomedical Engineering and Informatics (BMEI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309408","display_name":"Indiana Clinical and Translational Sciences Institute","ror":"https://ror.org/022t7q367"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W1971996334","https://openalex.org/W1978139063","https://openalex.org/W1992955004","https://openalex.org/W2118877693"],"related_works":["https://openalex.org/W1966243612","https://openalex.org/W3094427720","https://openalex.org/W2387336222","https://openalex.org/W4365149994","https://openalex.org/W4386840302","https://openalex.org/W2085363859","https://openalex.org/W2905994422","https://openalex.org/W2047857963","https://openalex.org/W2084126249","https://openalex.org/W2791632439"],"abstract_inverted_index":{"Traumatic":[0],"damage":[1],"to":[2,17,28,106,112,135,140],"the":[3,43,54,76,92,100,114],"nervous":[4],"system":[5],"severs":[6],"axons":[7],"and":[8,48,53,122,131,161],"causes":[9],"disabling":[10],"injury.":[11],"Regenerative":[12],"therapies":[13,31],"are":[14],"being":[15],"designed":[16],"encourage":[18],"regain":[19],"of":[20,42,78,84,94,109,137],"function.":[21],"However,":[22],"limitations":[23],"in":[24,58,71],"regeneration":[25],"present":[26],"challenges":[27],"tissue":[29,96],"engineering":[30],"for":[32,69,158],"neural":[33],"trauma.":[34],"Neuronal":[35],"growth":[36,160],"is":[37],"affected":[38],"by":[39],"many":[40],"properties":[41,64,139],"local":[44],"environment,":[45],"including":[46],"chemical":[47],"mechanical":[49],"interactions":[50],"between":[51],"neurites":[52],"substrate.":[55],"Most":[56],"experiments":[57],"this":[59],"field":[60],"have":[61,126],"controlled":[62],"biomaterial":[63],"using":[65],"reactive":[66],"aldehydes":[67],"unsuitable":[68],"use":[70,77],"vivo.":[72],"Instead,":[73],"we":[74,103,125],"evaluate":[75],"a":[79,155],"biocompatible":[80],"crosslinking":[81],"agent,":[82],"genipin,":[83],"natural":[85],"origin.":[86],"Chitosan,":[87],"an":[88],"established":[89],"biopolymer,":[90],"formed":[91],"backbone":[93],"our":[95],"scaffolds.":[97],"By":[98],"varying":[99],"chitosan:genipin":[101],"ratio,":[102],"were":[104],"able":[105],"create":[107],"hydrogels":[108],"tunable":[110],"stiffness":[111],"examine":[113],"effect":[115],"on":[116],"neuronal":[117],"regeneration.":[118],"Using":[119],"cell":[120],"culture":[121],"rheological":[123],"techniques,":[124],"characterized":[127],"these":[128],"chitosan-genipin":[129],"biomaterials":[130],"observed":[132],"preferential":[133],"adherence":[134],"substrates":[136],"similar":[138],"native":[141],"nerve.":[142],"These":[143],"findings":[144],"suggest":[145],"that":[146],"genipin":[147],"loaded":[148],"chitosan":[149],"gels":[150],"can":[151],"be":[152],"used":[153],"as":[154],"viable":[156],"substrate":[157],"nerve":[159],"repair.":[162]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
