{"id":"https://openalex.org/W2049652194","doi":"https://doi.org/10.1109/bmei.2011.6098531","title":"Drug efficiency of a novel anti-proliferative conjugate: Periodate-oxidized chitosan-g-mitomycin C","display_name":"Drug efficiency of a novel anti-proliferative conjugate: Periodate-oxidized chitosan-g-mitomycin C","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W2049652194","doi":"https://doi.org/10.1109/bmei.2011.6098531","mag":"2049652194"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2011.6098531","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2011.6098531","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 4th International Conference on Biomedical Engineering and Informatics (BMEI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101748795","display_name":"Lihong Duan","orcid":"https://orcid.org/0000-0001-5075-2858"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lihong Duan","raw_affiliation_strings":["Sun yatsen University, Institute of Polymer Science, College of Chemistry and Chemical Engineering, Guangzhou, China","Institute of Polymer Science College of Chemistry and Chemical Engineering, Sun yat-sen University, Guangzhou City, China"],"affiliations":[{"raw_affiliation_string":"Sun yatsen University, Institute of Polymer Science, College of Chemistry and Chemical Engineering, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Institute of Polymer Science College of Chemistry and Chemical Engineering, Sun yat-sen University, Guangzhou City, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100619636","display_name":"Xiaoning Li","orcid":"https://orcid.org/0000-0003-4770-7436"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoning Li","raw_affiliation_strings":["Zhongshan Ophthalmic Center, Sun yat-sen University, Guangzhou, China","Zhongshan Ophthalmic Center Sun yat-sen University Guangzhou City, China"],"affiliations":[{"raw_affiliation_string":"Zhongshan Ophthalmic Center, Sun yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Zhongshan Ophthalmic Center Sun yat-sen University Guangzhou City, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060122310","display_name":"Qiongjuan Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiongjuan Zheng","raw_affiliation_strings":["Sun yatsen University, Institute of Polymer Science, College of Chemistry and Chemical Engineering, Guangzhou, China","Institute of Polymer Science College of Chemistry and Chemical Engineering, Sun yat-sen University, Guangzhou City, China"],"affiliations":[{"raw_affiliation_string":"Sun yatsen University, Institute of Polymer Science, College of Chemistry and Chemical Engineering, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Institute of Polymer Science College of Chemistry and Chemical Engineering, Sun yat-sen University, Guangzhou City, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063909805","display_name":"Daping Quan","orcid":"https://orcid.org/0000-0002-6360-4341"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daping Quan","raw_affiliation_strings":["Sun yatsen University, Institute of Polymer Science, College of Chemistry and Chemical Engineering, Guangzhou, China","Institute of Polymer Science College of Chemistry and Chemical Engineering, Sun yat-sen University, Guangzhou City, China"],"affiliations":[{"raw_affiliation_string":"Sun yatsen University, Institute of Polymer Science, College of Chemistry and Chemical Engineering, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Institute of Polymer Science College of Chemistry and Chemical Engineering, Sun yat-sen University, Guangzhou City, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100758719","display_name":"Jian Ge","orcid":"https://orcid.org/0000-0001-5165-3368"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Ge","raw_affiliation_strings":["Zhongshan Ophthalmic Center, Sun yat-sen University, Guangzhou, China","Zhongshan Ophthalmic Center Sun yat-sen University Guangzhou City, China"],"affiliations":[{"raw_affiliation_string":"Zhongshan Ophthalmic Center, Sun yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Zhongshan Ophthalmic Center Sun yat-sen University Guangzhou City, China","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101748795"],"corresponding_institution_ids":["https://openalex.org/I157773358"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1084217,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"201","issue":null,"first_page":"1209","last_page":"1212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"Mitomycin C","score":0.872494101524353},{"id":"https://openalex.org/keywords/conjugate","display_name":"Conjugate","score":0.8622908592224121},{"id":"https://openalex.org/keywords/chitosan","display_name":"Chitosan","score":0.780829668045044},{"id":"https://openalex.org/keywords/periodate","display_name":"Periodate","score":0.709941029548645},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"Cytotoxicity","score":0.660088062286377},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6472153067588806},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"Flow cytometry","score":0.608123242855072},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.38297539949417114},{"id":"https://openalex.org/keywords/nuclear-chemistry","display_name":"Nuclear chemistry","score":0.359313428401947},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2407991886138916},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.19755256175994873},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12698686122894287},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12270992994308472},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.1126214861869812},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.0709383487701416}],"concepts":[{"id":"https://openalex.org/C2779338040","wikidata":"https://www.wikidata.org/wiki/Q19856779","display_name":"Mitomycin C","level":2,"score":0.872494101524353},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.8622908592224121},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.780829668045044},{"id":"https://openalex.org/C2776789926","wikidata":"https://www.wikidata.org/wiki/Q417139","display_name":"Periodate","level":2,"score":0.709941029548645},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.660088062286377},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6472153067588806},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.608123242855072},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.38297539949417114},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.359313428401947},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2407991886138916},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.19755256175994873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12698686122894287},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12270992994308472},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1126214861869812},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0709383487701416},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2011.6098531","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2011.6098531","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 4th International Conference on Biomedical Engineering and Informatics (BMEI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1966319910","https://openalex.org/W1972979183","https://openalex.org/W1975645481","https://openalex.org/W1979109189","https://openalex.org/W1980131427","https://openalex.org/W1997362853","https://openalex.org/W1997409302","https://openalex.org/W2009209548","https://openalex.org/W2011063223","https://openalex.org/W2011265206","https://openalex.org/W2016135728","https://openalex.org/W2026932813","https://openalex.org/W2033063864","https://openalex.org/W2045196856","https://openalex.org/W2064301088","https://openalex.org/W2065386894","https://openalex.org/W2080179284","https://openalex.org/W2088327358","https://openalex.org/W2088697330","https://openalex.org/W2093833404","https://openalex.org/W2134954483","https://openalex.org/W2139636480","https://openalex.org/W2141134706","https://openalex.org/W2321852657"],"related_works":["https://openalex.org/W1558029346","https://openalex.org/W2016562880","https://openalex.org/W2075001383","https://openalex.org/W154730693","https://openalex.org/W2120330316","https://openalex.org/W3109122827","https://openalex.org/W2046162196","https://openalex.org/W1915386939","https://openalex.org/W31544616","https://openalex.org/W2318208776"],"abstract_inverted_index":{"Mitomycin":[0,21],"C":[1,22,65],"is":[2,7],"an":[3],"anti-proliferative":[4,31],"agent":[5],"which":[6],"usually":[8],"adopted":[9],"to":[10],"prevent":[11],"fibroblast":[12],"proliferation":[13,52],"in":[14],"trabeculectomy.":[15],"However,":[16],"the":[17,61,74],"shorter":[18],"half-life":[19],"of":[20,41,76],"limits":[23],"its":[24],"use.":[25],"In":[26],"this":[27],"paper,":[28],"a":[29,68],"novel":[30],"conjugate":[32],"was":[33],"synthesized":[34],"by":[35,50],"Schiff":[36],"base":[37],"reaction.":[38],"The":[39,56],"cytotoxicity":[40],"periodate-oxidized":[42,63],"chitosan":[43],"and":[44],"drug":[45],"efficiency":[46],"were":[47],"also":[48],"performed":[49],"cell":[51],"assay,":[53],"flow":[54],"cytometry.":[55],"results":[57],"clearly":[58],"suggested":[59],"that":[60],"conjugate:":[62],"chitosan-g-mitomycin":[64],"could":[66],"be":[67],"suitable":[69],"polymeric":[70],"system":[71],"for":[72],"controlling":[73],"release":[75],"mitomycin":[77],"C.":[78]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
