{"id":"https://openalex.org/W1992013263","doi":"https://doi.org/10.1109/bmei.2011.6098514","title":"Gene differential expression analysis for leukemia based on relative risk","display_name":"Gene differential expression analysis for leukemia based on relative risk","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W1992013263","doi":"https://doi.org/10.1109/bmei.2011.6098514","mag":"1992013263"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2011.6098514","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2011.6098514","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 4th International Conference on Biomedical Engineering and Informatics (BMEI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081105679","display_name":"Yang Yu","orcid":"https://orcid.org/0000-0002-4093-505X"},"institutions":[{"id":"https://openalex.org/I10660446","display_name":"Kunming University of Science and Technology","ror":"https://ror.org/00xyeez13","country_code":"CN","type":"education","lineage":["https://openalex.org/I10660446"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Yu","raw_affiliation_strings":["Kunming University of Science and Technology, Kunming, China","Kunming University of Science and Technology, Kunming, CHINA"],"affiliations":[{"raw_affiliation_string":"Kunming University of Science and Technology, Kunming, China","institution_ids":["https://openalex.org/I10660446"]},{"raw_affiliation_string":"Kunming University of Science and Technology, Kunming, CHINA","institution_ids":["https://openalex.org/I10660446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100702169","display_name":"Junpeng Zhang","orcid":"https://orcid.org/0000-0001-6127-9701"},"institutions":[{"id":"https://openalex.org/I10660446","display_name":"Kunming University of Science and Technology","ror":"https://ror.org/00xyeez13","country_code":"CN","type":"education","lineage":["https://openalex.org/I10660446"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junpeng Zhang","raw_affiliation_strings":["Kunming University of Science and Technology, Kunming, China","Kunming University of Science and Technology, Kunming, CHINA"],"affiliations":[{"raw_affiliation_string":"Kunming University of Science and Technology, Kunming, China","institution_ids":["https://openalex.org/I10660446"]},{"raw_affiliation_string":"Kunming University of Science and Technology, Kunming, CHINA","institution_ids":["https://openalex.org/I10660446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062082438","display_name":"Jianfeng He","orcid":"https://orcid.org/0000-0001-6995-2980"},"institutions":[{"id":"https://openalex.org/I10660446","display_name":"Kunming University of Science and Technology","ror":"https://ror.org/00xyeez13","country_code":"CN","type":"education","lineage":["https://openalex.org/I10660446"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianfeng He","raw_affiliation_strings":["Kunming University of Science and Technology, Kunming, China","Kunming University of Science and Technology, Kunming, CHINA"],"affiliations":[{"raw_affiliation_string":"Kunming University of Science and Technology, Kunming, China","institution_ids":["https://openalex.org/I10660446"]},{"raw_affiliation_string":"Kunming University of Science and Technology, Kunming, CHINA","institution_ids":["https://openalex.org/I10660446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101455618","display_name":"Lei Ma","orcid":"https://orcid.org/0000-0002-1426-1848"},"institutions":[{"id":"https://openalex.org/I10660446","display_name":"Kunming University of Science and Technology","ror":"https://ror.org/00xyeez13","country_code":"CN","type":"education","lineage":["https://openalex.org/I10660446"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Ma","raw_affiliation_strings":["Kunming University of Science and Technology, Kunming, China","Kunming University of Science and Technology, Kunming, CHINA"],"affiliations":[{"raw_affiliation_string":"Kunming University of Science and Technology, Kunming, China","institution_ids":["https://openalex.org/I10660446"]},{"raw_affiliation_string":"Kunming University of Science and Technology, Kunming, CHINA","institution_ids":["https://openalex.org/I10660446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5081105679"],"corresponding_institution_ids":["https://openalex.org/I10660446"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.06673803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"286","issue":null,"first_page":"1733","last_page":"1737"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9905999898910522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9708999991416931,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6430274248123169},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5894249081611633},{"id":"https://openalex.org/keywords/leukemia","display_name":"Leukemia","score":0.5578746795654297},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5485931634902954},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4574434459209442},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41884270310401917},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3238418698310852},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30802008509635925}],"concepts":[{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6430274248123169},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5894249081611633},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5578746795654297},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5485931634902954},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4574434459209442},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41884270310401917},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3238418698310852},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30802008509635925}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2011.6098514","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2011.6098514","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 4th International Conference on Biomedical Engineering and Informatics (BMEI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4699999988079071,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1506078357","https://openalex.org/W1556933466","https://openalex.org/W1912123407","https://openalex.org/W2008056655","https://openalex.org/W2062989416","https://openalex.org/W2109363337","https://openalex.org/W2123600054","https://openalex.org/W2125055259","https://openalex.org/W2261963636","https://openalex.org/W2325343629","https://openalex.org/W4239510810","https://openalex.org/W4253551305","https://openalex.org/W4254645089","https://openalex.org/W4299737965"],"related_works":["https://openalex.org/W106077234","https://openalex.org/W3032874291","https://openalex.org/W2005057264","https://openalex.org/W2041374557","https://openalex.org/W2081929287","https://openalex.org/W2363156284","https://openalex.org/W2415025170","https://openalex.org/W2144348650","https://openalex.org/W2132561013","https://openalex.org/W1994852842"],"abstract_inverted_index":{"The":[0,54,65],"occurrence":[1],"and":[2,12,81,94],"development":[3],"of":[4,29,32,86,89,102],"tumor":[5,21],"is":[6,108],"usually":[7],"caused":[8],"by":[9],"gene":[10,30,40,61],"mutation":[11],"abnormal":[13],"expression,":[14],"thus,":[15],"differentially":[16,51],"expressed":[17,52],"genes":[18,77],"associated":[19],"with":[20,79,98],"provide":[22],"a":[23,39],"significant":[24],"reference":[25],"in":[26,59],"the":[27,70,83,105],"process":[28],"therapy":[31],"tumor.":[33],"In":[34],"this":[35],"paper,":[36],"we":[37],"propose":[38],"differential":[41,75],"expression":[42,62,76],"analysis":[43],"method":[44,56,71,107],"based":[45],"on":[46],"relative":[47],"risk":[48],"to":[49],"extract":[50,73],"genes.":[53],"proposed":[55,106],"was":[57],"tested":[58],"leukemia":[60],"data":[63],"set.":[64],"experimental":[66],"results":[67],"show":[68],"that":[69],"can":[72],"significantly":[74],"related":[78],"leukemia,":[80],"improve":[82],"classification":[84],"accuracy":[85],"three":[87],"state-of-the-arts":[88],"classifiers:":[90],"C4.5,":[91],"Naive":[92],"Bayes":[93],"SVM.":[95],"Furthermore,":[96],"compared":[97],"SAM":[99],"(Significance":[100],"Analysis":[101],"Microarrays)":[103],"method,":[104],"more":[109],"accurate":[110],"for":[111],"classification.":[112]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}