{"id":"https://openalex.org/W2132242715","doi":"https://doi.org/10.1109/bmei.2009.5305738","title":"A Nonlinear Model and an Optimization Algorithm to Infer Genetic Interactions","display_name":"A Nonlinear Model and an Optimization Algorithm to Infer Genetic Interactions","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2132242715","doi":"https://doi.org/10.1109/bmei.2009.5305738","mag":"2132242715"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2009.5305738","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5305738","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101981950","display_name":"Chung\u2010Ming Chen","orcid":"https://orcid.org/0000-0002-0023-5817"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chung-Ming Chen","raw_affiliation_strings":["Institute of Biomedical Engineering, National Taiwan University, Taiwan","Inst. of Biomed Eng., Nat. Taiwan Univ., Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Inst. of Biomed Eng., Nat. Taiwan Univ., Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080081771","display_name":"Cheng-Long Chuang","orcid":"https://orcid.org/0000-0003-1913-8168"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Long Chuang","raw_affiliation_strings":["Institute of Biomedical Engineering, National Taiwan University, Taiwan","Inst. of Biomed Eng., Nat. Taiwan Univ., Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Inst. of Biomed Eng., Nat. Taiwan Univ., Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034244635","display_name":"Chi Lee","orcid":"https://orcid.org/0009-0001-2706-9580"},"institutions":[{"id":"https://openalex.org/I4210141710","display_name":"Institute of Statistical Science, Academia Sinica","ror":"https://ror.org/044gv5910","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210141710","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chi Lee","raw_affiliation_strings":["Institute of Statistical Science, Academia Sinica, Taiwan","Inst. of Stat. Sci., Acad. Sinica, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Statistical Science, Academia Sinica, Taiwan","institution_ids":["https://openalex.org/I4210141710"]},{"raw_affiliation_string":"Inst. of Stat. Sci., Acad. Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210141710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036834541","display_name":"Chia-Chang Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210141710","display_name":"Institute of Statistical Science, Academia Sinica","ror":"https://ror.org/044gv5910","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210141710","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Chang Wang","raw_affiliation_strings":["Institute of Statistical Science, Academia Sinica, Taiwan","Inst. of Stat. Sci., Acad. Sinica, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Statistical Science, Academia Sinica, Taiwan","institution_ids":["https://openalex.org/I4210141710"]},{"raw_affiliation_string":"Inst. of Stat. Sci., Acad. Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210141710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018129033","display_name":"Grace S. Shieh","orcid":"https://orcid.org/0000-0001-7646-6753"},"institutions":[{"id":"https://openalex.org/I4210141710","display_name":"Institute of Statistical Science, Academia Sinica","ror":"https://ror.org/044gv5910","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210141710","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Grace S. Shieh","raw_affiliation_strings":["Institute of Statistical Science, Academia Sinica, Taiwan","Inst. of Stat. Sci., Acad. Sinica, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Statistical Science, Academia Sinica, Taiwan","institution_ids":["https://openalex.org/I4210141710"]},{"raw_affiliation_string":"Inst. of Stat. Sci., Acad. Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210141710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101981950"],"corresponding_institution_ids":["https://openalex.org/I16733864"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15045729,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"277","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9855999946594238,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simulated-annealing","display_name":"Simulated annealing","score":0.7892980575561523},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.6466062068939209},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.5832476019859314},{"id":"https://openalex.org/keywords/gradient-descent","display_name":"Gradient descent","score":0.5472748279571533},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.5308495759963989},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49316614866256714},{"id":"https://openalex.org/keywords/subnetwork","display_name":"Subnetwork","score":0.49131694436073303},{"id":"https://openalex.org/keywords/optimization-algorithm","display_name":"Optimization algorithm","score":0.44436320662498474},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.2712445557117462},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.26125770807266235},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17282551527023315},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.13154730200767517},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.08117610216140747},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.07903343439102173}],"concepts":[{"id":"https://openalex.org/C126980161","wikidata":"https://www.wikidata.org/wiki/Q863783","display_name":"Simulated annealing","level":2,"score":0.7892980575561523},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.6466062068939209},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5832476019859314},{"id":"https://openalex.org/C153258448","wikidata":"https://www.wikidata.org/wiki/Q1199743","display_name":"Gradient descent","level":3,"score":0.5472748279571533},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.5308495759963989},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49316614866256714},{"id":"https://openalex.org/C2780186347","wikidata":"https://www.wikidata.org/wiki/Q11414","display_name":"Subnetwork","level":2,"score":0.49131694436073303},{"id":"https://openalex.org/C2987595161","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Optimization algorithm","level":2,"score":0.44436320662498474},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.2712445557117462},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.26125770807266235},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17282551527023315},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.13154730200767517},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08117610216140747},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.07903343439102173},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2009.5305738","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5305738","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W2011039300","https://openalex.org/W2011912935","https://openalex.org/W2025128734","https://openalex.org/W2030315334","https://openalex.org/W2041274449","https://openalex.org/W2046713384","https://openalex.org/W2056760934","https://openalex.org/W2062976265","https://openalex.org/W2092091227","https://openalex.org/W2117813324","https://openalex.org/W2127788692","https://openalex.org/W2134092975","https://openalex.org/W2138309709","https://openalex.org/W2141239733","https://openalex.org/W2146506956","https://openalex.org/W2148563299","https://openalex.org/W2158214348","https://openalex.org/W2166667584","https://openalex.org/W2476096155","https://openalex.org/W3023411394","https://openalex.org/W6677395652"],"related_works":["https://openalex.org/W2060724872","https://openalex.org/W2082094785","https://openalex.org/W2202198356","https://openalex.org/W3087203342","https://openalex.org/W2377184161","https://openalex.org/W1585212810","https://openalex.org/W2353965122","https://openalex.org/W2362998257","https://openalex.org/W2360697892","https://openalex.org/W2382364780"],"abstract_inverted_index":{"An":[0,56],"S-shape":[1],"model":[2],"and":[3,14,34],"an":[4],"optimization":[5],"algorithm":[6,33,48],"(GASA)":[7],"are":[8,75],"developed":[9],"to":[10,49],"infer":[11],"genetic":[12,32],"interactions":[13,74],"transcriptional":[15],"regulation":[16],"of":[17,30,58,66],"a":[18,31,35,44,64],"few":[19],"genes":[20],"simultaneously":[21],"using":[22],"microarray":[23],"gene":[24],"expression":[25],"data":[26],"(MGED).":[27],"GASA":[28,59],"consists":[29],"simulated":[36],"annealing":[37],"(SA)":[38],"algorithm,":[39],"which":[40,63],"is":[41,60,70],"enhanced":[42],"by":[43,77],"steepest":[45],"gradient":[46],"descent":[47],"avoid":[50],"being":[51],"trapped":[52],"in":[53,62],"local":[54],"minimum.":[55],"application":[57],"demonstrated,":[61],"subnetwork":[65],"human":[67],"T-cell":[68],"apoptosis":[69],"inferred.":[71],"Several":[72],"predicted":[73],"supported":[76],"literature.":[78]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}