{"id":"https://openalex.org/W2153692144","doi":"https://doi.org/10.1109/bmei.2009.5305460","title":"A Photo-Crosslinkable Chitosan Hydrogel for Peripheral Nerve Anastomosis","display_name":"A Photo-Crosslinkable Chitosan Hydrogel for Peripheral Nerve Anastomosis","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2153692144","doi":"https://doi.org/10.1109/bmei.2009.5305460","mag":"2153692144"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2009.5305460","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5305460","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060699579","display_name":"Todd Rickett","orcid":null},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Todd Rickett","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA"],"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040715170","display_name":"Zohreh Amoozgar","orcid":"https://orcid.org/0000-0001-8285-8024"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zohreh Amoozgar","raw_affiliation_strings":["Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, USA"],"affiliations":[{"raw_affiliation_string":"Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081646363","display_name":"Wenjing Sun","orcid":"https://orcid.org/0000-0002-0905-7420"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenjing Sun","raw_affiliation_strings":["Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, USA"],"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054139199","display_name":"Yoon Yeo","orcid":"https://orcid.org/0000-0001-9505-7701"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoon Yeo","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, USA"],"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058022813","display_name":"Riyi Shi","orcid":"https://orcid.org/0000-0002-7297-9428"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Riyi Shi","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, USA"],"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5060699579"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":null,"apc_paid":null,"fwci":0.2413,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.51211519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12459","display_name":"Nerve Injury and Rehabilitation","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitosan","display_name":"Chitosan","score":0.8374384641647339},{"id":"https://openalex.org/keywords/fibrin-glue","display_name":"Fibrin glue","score":0.7864406108856201},{"id":"https://openalex.org/keywords/carbodiimide","display_name":"Carbodiimide","score":0.6927079558372498},{"id":"https://openalex.org/keywords/fibrin","display_name":"Fibrin","score":0.6829313039779663},{"id":"https://openalex.org/keywords/fibrous-joint","display_name":"Fibrous joint","score":0.6138954162597656},{"id":"https://openalex.org/keywords/peripheral-nerve-injury","display_name":"Peripheral nerve injury","score":0.5556080937385559},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5067811608314514},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.474423348903656},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"Tissue engineering","score":0.4416901767253876},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.4400535225868225},{"id":"https://openalex.org/keywords/ex-vivo","display_name":"Ex vivo","score":0.41606059670448303},{"id":"https://openalex.org/keywords/peripheral-nerve","display_name":"Peripheral nerve","score":0.39476341009140015},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.29902106523513794},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.289406418800354},{"id":"https://openalex.org/keywords/polymer-chemistry","display_name":"Polymer chemistry","score":0.23990663886070251},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18573319911956787},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.17058825492858887},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.13673970103263855},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.07440745830535889},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.06485947966575623}],"concepts":[{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.8374384641647339},{"id":"https://openalex.org/C2781472170","wikidata":"https://www.wikidata.org/wiki/Q1410780","display_name":"Fibrin glue","level":2,"score":0.7864406108856201},{"id":"https://openalex.org/C2775997276","wikidata":"https://www.wikidata.org/wiki/Q420241","display_name":"Carbodiimide","level":2,"score":0.6927079558372498},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.6829313039779663},{"id":"https://openalex.org/C2777327002","wikidata":"https://www.wikidata.org/wiki/Q2865760","display_name":"Fibrous joint","level":2,"score":0.6138954162597656},{"id":"https://openalex.org/C2776880756","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Peripheral nerve injury","level":3,"score":0.5556080937385559},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5067811608314514},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.474423348903656},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4416901767253876},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4400535225868225},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.41606059670448303},{"id":"https://openalex.org/C3018498973","wikidata":"https://www.wikidata.org/wiki/Q9620","display_name":"Peripheral nerve","level":2,"score":0.39476341009140015},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29902106523513794},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.289406418800354},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.23990663886070251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18573319911956787},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.17058825492858887},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13673970103263855},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07440745830535889},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06485947966575623},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2009.5305460","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5305460","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5600000023841858,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W77663427","https://openalex.org/W96587930","https://openalex.org/W1753091109","https://openalex.org/W1980841244","https://openalex.org/W1987017096","https://openalex.org/W2001308282","https://openalex.org/W2017795859","https://openalex.org/W2035851415","https://openalex.org/W2051894319","https://openalex.org/W2066511695","https://openalex.org/W2123500293","https://openalex.org/W2134720352","https://openalex.org/W2153293010","https://openalex.org/W4312461342"],"related_works":["https://openalex.org/W2794941383","https://openalex.org/W2364607271","https://openalex.org/W2352235029","https://openalex.org/W3202462869","https://openalex.org/W2393854736","https://openalex.org/W2392436781","https://openalex.org/W2394293852","https://openalex.org/W2588978415","https://openalex.org/W2016872415","https://openalex.org/W2329949148"],"abstract_inverted_index":{"The":[0],"predominant":[1,33],"therapy":[2],"for":[3,44,49,134],"peripheral":[4,50],"nerve":[5,51,103,137],"transection":[6],"is":[7,88,98],"anastomosis":[8],"by":[9,54,112],"suture.":[10],"However,":[11],"sutures":[12],"have":[13],"been":[14],"known":[15],"to":[16,18,58,90,102,119,128],"lead":[17],"tissue":[19],"inflammation,":[20],"granulomas,":[21],"and":[22,97,131],"poor":[23],"functional":[24],"outcomes.":[25],"While":[26],"adhesives":[27],"offer":[28],"a":[29,40,69],"promising":[30],"alternative,":[31],"fibrin-the":[32],"bio-glue-can":[34],"transmit":[35],"disease.":[36],"Here":[37],"we":[38],"examine":[39],"photocrosslinkable":[41],"chitosan":[42,62,126],"hydrogel":[43,114,127],"use":[45,135],"in":[46,136],"surgical":[47],"therapies":[48],"injury.":[52],"Prepared":[53],"conjugating":[55],"4-azidobenzoic":[56],"acid":[57],"amino":[59],"groups":[60],"of":[61,72,83,109],"using":[63],"carbodiimide":[64],"chemistry,":[65],"this":[66,113],"formulation":[67],"demonstrates":[68],"high":[70],"potential":[71],"in-situ":[73],"photocrosslinking.":[74],"A":[75],"40":[76,81],"mg/mL":[77],"solution":[78],"gels":[79],"under":[80],"s":[82],"UV":[84],"illumination.":[85],"This":[86],"gel":[87],"demonstrated":[89],"be":[91,129],"cytocompatible":[92],"with":[93],"neural":[94],"cell":[95],"populations":[96],"not":[99],"acutely":[100],"toxic":[101],"conduction":[104],"ex":[105],"vivo.":[106],"Mechanical":[107],"testing":[108],"nerves":[110],"anastomosed":[111],"had":[115],"tensile":[116],"strengths":[117],"comparable":[118],"conventional":[120],"fibrin":[121],"glues.":[122],"These":[123],"results":[124],"show":[125],"biocompatible":[130],"mechanically":[132],"suitable":[133],"repair.":[138]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}