{"id":"https://openalex.org/W2144246181","doi":"https://doi.org/10.1109/bmei.2009.5305032","title":"Clinical Information Driven Ensemble Clustering for Inferring Robust Tumor Subtypes","display_name":"Clinical Information Driven Ensemble Clustering for Inferring Robust Tumor Subtypes","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2144246181","doi":"https://doi.org/10.1109/bmei.2009.5305032","mag":"2144246181"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2009.5305032","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5305032","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100601473","display_name":"Haiyun Wang","orcid":"https://orcid.org/0000-0001-8364-8328"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haiyun Wang","raw_affiliation_strings":["School of Life Science and Technology, Tongji University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006025102","display_name":"Min Ding","orcid":"https://orcid.org/0000-0002-6373-7929"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Ding","raw_affiliation_strings":["School of Life Science and Technology, Tongji University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101755307","display_name":"Xia Li","orcid":"https://orcid.org/0000-0002-5415-633X"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Li","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","School of Life Science and Technology, Tongji University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"School of Life Science and Technology, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081095213","display_name":"Bairong Shen","orcid":"https://orcid.org/0000-0003-2899-1531"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bairong Shen","raw_affiliation_strings":["School of Life Science and Technology, Tongji University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100445596","display_name":"Xia Li","orcid":"https://orcid.org/0000-0002-9794-2648"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Li","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","School of Life Science and Technology, Tongji University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"School of Life Science and Technology, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100601473"],"corresponding_institution_ids":["https://openalex.org/I116953780"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.15364862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"7","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.755481481552124},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6307393312454224},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5635764002799988},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4838820695877075},{"id":"https://openalex.org/keywords/consensus-clustering","display_name":"Consensus clustering","score":0.4170917868614197},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.410935640335083},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.35833925008773804},{"id":"https://openalex.org/keywords/correlation-clustering","display_name":"Correlation clustering","score":0.16599580645561218},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16386154294013977},{"id":"https://openalex.org/keywords/cure-data-clustering-algorithm","display_name":"CURE data clustering algorithm","score":0.15131732821464539},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1255168616771698}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.755481481552124},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6307393312454224},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5635764002799988},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4838820695877075},{"id":"https://openalex.org/C186767784","wikidata":"https://www.wikidata.org/wiki/Q5162841","display_name":"Consensus clustering","level":5,"score":0.4170917868614197},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.410935640335083},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35833925008773804},{"id":"https://openalex.org/C94641424","wikidata":"https://www.wikidata.org/wiki/Q5172845","display_name":"Correlation clustering","level":3,"score":0.16599580645561218},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16386154294013977},{"id":"https://openalex.org/C33704608","wikidata":"https://www.wikidata.org/wiki/Q5014717","display_name":"CURE data clustering algorithm","level":4,"score":0.15131732821464539},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1255168616771698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2009.5305032","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5305032","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1503899947","https://openalex.org/W1546709038","https://openalex.org/W1886306325","https://openalex.org/W1970580356","https://openalex.org/W1970586717","https://openalex.org/W2097255042","https://openalex.org/W2097413644","https://openalex.org/W2107318313","https://openalex.org/W2109276980","https://openalex.org/W2113962581","https://openalex.org/W2125739312","https://openalex.org/W2131994307","https://openalex.org/W2135000328","https://openalex.org/W2147246240","https://openalex.org/W2150926065","https://openalex.org/W2156273110","https://openalex.org/W2157840751","https://openalex.org/W2168561598"],"related_works":["https://openalex.org/W2588528840","https://openalex.org/W2199594781","https://openalex.org/W2767663474","https://openalex.org/W2744974730","https://openalex.org/W2285903080","https://openalex.org/W2294414050","https://openalex.org/W4386076172","https://openalex.org/W4306311884","https://openalex.org/W2584267197","https://openalex.org/W1574003721"],"abstract_inverted_index":{"Inferring":[0],"tumor":[1,32,59,89,115],"subtypes":[2],"based":[3],"on":[4],"the":[5,20,48,58,74,81,84],"gene":[6],"expression":[7],"data":[8],"alone":[9],"does":[10],"not":[11],"appear":[12],"to":[13,36,95,109],"be":[14,35],"as":[15,17],"powerful":[16],"expected":[18,94],"for":[19,54,80],"lack":[21],"of":[22,30,57,83,114],"robustness":[23],"and":[24,61,77,86,99,108],"clinical":[25,38,49,75],"meaning.":[26],"The":[27],"ultimate":[28],"aim":[29],"clustering":[31,43,70],"samples":[33],"should":[34,45],"support":[37],"evaluation":[39],"or":[40],"treatment.":[41],"Therefore,":[42],"procedure":[44],"closely":[46],"integrate":[47],"outcome":[50,76],"and/or":[51],"treatment":[52,78],"information":[53,79],"final":[55],"representation":[56],"homogeneity":[60],"heterogeneity.":[62,116],"In":[63],"this":[64],"work,":[65],"we":[66],"developed":[67],"an":[68],"ensemble":[69],"method":[71,92],"guided":[72],"by":[73],"identification":[82],"robust":[85,98],"clinically":[87,100],"meaningful":[88],"subtypes.":[90],"Our":[91],"was":[93],"yield":[96],"more":[97],"relevant":[101],"results":[102],"than":[103],"other":[104],"commonly":[105],"used":[106],"methods":[107],"give":[110],"us":[111],"comprehensive":[112],"understanding":[113]},"counts_by_year":[{"year":2013,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
