{"id":"https://openalex.org/W2112200171","doi":"https://doi.org/10.1109/bmei.2009.5302325","title":"A Novel Strategy for Designing Dual-Target Inhibitors of KU86 and XRCC4","display_name":"A Novel Strategy for Designing Dual-Target Inhibitors of KU86 and XRCC4","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2112200171","doi":"https://doi.org/10.1109/bmei.2009.5302325","mag":"2112200171"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2009.5302325","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5302325","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100710720","display_name":"Chien\u2010Yu Chen","orcid":"https://orcid.org/0000-0002-6940-6389"},"institutions":[{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chien-Yu Chen","raw_affiliation_strings":["Department of Bioinformatics, Asia University, Taichung, Taiwan","Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Asia University, Taichung, Taiwan","institution_ids":["https://openalex.org/I143578492"]},{"raw_affiliation_string":"Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030324810","display_name":"Fuu\u2010Jen Tsai","orcid":"https://orcid.org/0000-0002-1373-245X"},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]},{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Fuu-Jen Tsai","raw_affiliation_strings":["Department of Bioinformatics, Asia University, Taichung, Taiwan","Department of Medical Genetics, Pediatrics and Medical Research, College of Chinese Medicine, China Medical University and Hospital, Taichung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Asia University, Taichung, Taiwan","institution_ids":["https://openalex.org/I143578492"]},{"raw_affiliation_string":"Department of Medical Genetics, Pediatrics and Medical Research, College of Chinese Medicine, China Medical University and Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I4210126829","https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087091914","display_name":"Jing\u2010Gung Chung","orcid":"https://orcid.org/0000-0002-7303-2287"},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jing-Gung Chung","raw_affiliation_strings":["Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112822928","display_name":"Chang\u2010Hai Tsai","orcid":null},"institutions":[{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chang-Hai Tsai","raw_affiliation_strings":["Department of Healthcare Administration, Asia University, Taichung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Healthcare Administration, Asia University, Taichung, Taiwan","institution_ids":["https://openalex.org/I143578492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067002588","display_name":"Yuan\u2010Man Hsu","orcid":"https://orcid.org/0000-0002-4575-7475"},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yuan-Man Hsu","raw_affiliation_strings":["Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034415756","display_name":"Hung-Jin Huang","orcid":"https://orcid.org/0000-0003-2448-3919"},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hung-Jin Huang","raw_affiliation_strings":["Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021867307","display_name":"Tin\u2010Yun Ho","orcid":"https://orcid.org/0000-0003-2390-1461"},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tin-Yun Ho","raw_affiliation_strings":["Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110311695","display_name":"DA-TIAN BAU","orcid":null},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Da-Tian Bau","raw_affiliation_strings":["Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050504481","display_name":"Yea-Huey Chang","orcid":null},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yea-Huey Chang","raw_affiliation_strings":["Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113996324","display_name":"Ming\u2010Hsui Tsai","orcid":null},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Hsui Tsai","raw_affiliation_strings":["Terry Fox Cancer Research Laboratory, China Medical University, Taichung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Terry Fox Cancer Research Laboratory, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078562310","display_name":"Calvin Yu\u2010Chian Chen","orcid":"https://orcid.org/0000-0001-9213-9832"},"institutions":[{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Calvin Yu-Chian Chen","raw_affiliation_strings":["Department of Bioinformatics, Asia University, Taichung, Taiwan","Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Asia University, Taichung, Taiwan","institution_ids":["https://openalex.org/I143578492"]},{"raw_affiliation_string":"Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5100710720"],"corresponding_institution_ids":["https://openalex.org/I143578492","https://openalex.org/I184693016"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14511467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-repair-protein-xrcc4","display_name":"DNA repair protein XRCC4","score":0.6154242157936096},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.5337247848510742},{"id":"https://openalex.org/keywords/rational-design","display_name":"Rational design","score":0.5036210417747498},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4856911599636078},{"id":"https://openalex.org/keywords/drug-design","display_name":"Drug design","score":0.4729188084602356},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.44888415932655334},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.36904436349868774},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36285167932510376},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3230844736099243},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.25229138135910034},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.22524979710578918},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.19612956047058105},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15558576583862305},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13631919026374817}],"concepts":[{"id":"https://openalex.org/C145803527","wikidata":"https://www.wikidata.org/wiki/Q18032396","display_name":"DNA repair protein XRCC4","level":5,"score":0.6154242157936096},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5337247848510742},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.5036210417747498},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4856911599636078},{"id":"https://openalex.org/C192071366","wikidata":"https://www.wikidata.org/wiki/Q2991682","display_name":"Drug design","level":2,"score":0.4729188084602356},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.44888415932655334},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.36904436349868774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36285167932510376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3230844736099243},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25229138135910034},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.22524979710578918},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19612956047058105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15558576583862305},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13631919026374817},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2009.5302325","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5302325","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1969235650","https://openalex.org/W2006824325","https://openalex.org/W2010711320","https://openalex.org/W2041153072","https://openalex.org/W2068616735","https://openalex.org/W2076328665","https://openalex.org/W2079231747","https://openalex.org/W2080152855","https://openalex.org/W2080306818","https://openalex.org/W2080562279","https://openalex.org/W2102618729","https://openalex.org/W2106336456","https://openalex.org/W2115528176","https://openalex.org/W2121825207","https://openalex.org/W2121932810","https://openalex.org/W2144485510","https://openalex.org/W2152370879","https://openalex.org/W2160089420","https://openalex.org/W2166382251","https://openalex.org/W2169637630","https://openalex.org/W2261272733","https://openalex.org/W2346606136","https://openalex.org/W2409817548","https://openalex.org/W4241386561","https://openalex.org/W6681623523","https://openalex.org/W6692887485","https://openalex.org/W6705004488"],"related_works":["https://openalex.org/W2375593122","https://openalex.org/W4308805210","https://openalex.org/W2142728655","https://openalex.org/W36558656","https://openalex.org/W1974559214","https://openalex.org/W2090043682","https://openalex.org/W3211004259","https://openalex.org/W4386165652","https://openalex.org/W2021528276","https://openalex.org/W2080152438"],"abstract_inverted_index":{"This":[0],"is":[1],"the":[2,21,33,56,79,88,99,104],"first":[3],"time":[4],"that":[5],"we":[6],"reported":[7],"about":[8],"dual":[9],"target":[10],"inhibitors":[11],"of":[12,23,49,95],"KU86":[13,64],"and":[14,65,83,127,135],"XRCC4.":[15],"XRCC4":[16],"was":[17,52],"well":[18],"known":[19],"as":[20],"downstream":[22],"KU86-DNA":[24],"complex.":[25],"They":[26],"both":[27],"play":[28],"an":[29],"important":[30],"role":[31],"in":[32],"DNA":[34],"double-strain":[35],"breaks":[36],"(DSBs)":[37],"repair":[38],"system":[39],"subpathway,":[40],"non-homologous":[41],"end":[42],"joining":[43],"(NHEJ).In":[44],"this":[45],"study,":[46],"The":[47,70,92],"protocol":[48],"docking":[50,71],"analysis":[51],"applied":[53],"to":[54,63,107,130],"find":[55],"specific":[57],"compounds,":[58],"which":[59],"had":[60,86],"highest":[61],"affinities":[62,109],"XRCC4,":[66],"from":[67,98,110],"our":[68],"database.":[69],"results":[72,80],"were":[73],"analyzed":[74],"by":[75],"cross":[76],"validation.":[77],"From":[78],"above,":[81],"myricetin":[82],"xanthone":[84],"series":[85],"quietly":[87],"same":[89],"core":[90],"structure.":[91],"different":[93,108],"shapes":[94],"binding":[96],"sites":[97],"two":[100],"proteins":[101],"might":[102],"be":[103],"major":[105],"factor":[106],"these":[111],"three":[112],"potent":[113],"dual-target":[114,124],"inhibitors.":[115],"Our":[116],"work":[117],"provides":[118],"a":[119],"new":[120],"strategy":[121],"for":[122],"developing":[123],"anticancer":[125,132],"drug,":[126],"may":[128],"contribute":[129],"clinical":[131],"drug":[133],"discovery":[134],"application.":[136]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}