{"id":"https://openalex.org/W2057649846","doi":"https://doi.org/10.1109/biovis.2012.6378590","title":"Heterogeneity-based guidance for exploring multiscale data in systems biology","display_name":"Heterogeneity-based guidance for exploring multiscale data in systems biology","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2057649846","doi":"https://doi.org/10.1109/biovis.2012.6378590","mag":"2057649846"},"language":"en","primary_location":{"id":"doi:10.1109/biovis.2012.6378590","is_oa":false,"landing_page_url":"https://doi.org/10.1109/biovis.2012.6378590","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE Symposium on Biological Data Visualization (BioVis)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088223542","display_name":"Martin Luboschik","orcid":null},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Martin Luboschik","raw_affiliation_strings":["University of Rostock, Germany","University of Rostock, Rostock, Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"University of Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]},{"raw_affiliation_string":"University of Rostock, Rostock, Germany#TAB#","institution_ids":["https://openalex.org/I4665924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077806089","display_name":"Carsten Maus","orcid":null},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carsten Maus","raw_affiliation_strings":["University of Rostock, Germany","University of Rostock, Rostock, Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"University of Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]},{"raw_affiliation_string":"University of Rostock, Rostock, Germany#TAB#","institution_ids":["https://openalex.org/I4665924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088255721","display_name":"Hans\u2010J\u00f6rg Schulz","orcid":"https://orcid.org/0000-0001-9974-535X"},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Jorg Schulz","raw_affiliation_strings":["University of Rostock, Germany","University of Rostock, Rostock, Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"University of Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]},{"raw_affiliation_string":"University of Rostock, Rostock, Germany#TAB#","institution_ids":["https://openalex.org/I4665924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039180428","display_name":"Heidrun Schumann","orcid":null},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heidrun Schumann","raw_affiliation_strings":["University of Rostock, Germany","University of Rostock, Rostock, Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"University of Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]},{"raw_affiliation_string":"University of Rostock, Rostock, Germany#TAB#","institution_ids":["https://openalex.org/I4665924"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063515034","display_name":"Adelinde M. Uhrmacher","orcid":"https://orcid.org/0000-0001-5256-4682"},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Adelinde Uhrmacher","raw_affiliation_strings":["University of Rostock, Germany","University of Rostock, Rostock, Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"University of Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]},{"raw_affiliation_string":"University of Rostock, Rostock, Germany#TAB#","institution_ids":["https://openalex.org/I4665924"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5088223542"],"corresponding_institution_ids":["https://openalex.org/I4665924"],"apc_list":null,"apc_paid":null,"fwci":0.5876,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.81351002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"33","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9501000046730042,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9501000046730042,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9309999942779541,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10799","display_name":"Data Visualization and Analytics","score":0.9053999781608582,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5886995792388916},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.44505181908607483},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4077133536338806},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.28206467628479004},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2641238272190094}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5886995792388916},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.44505181908607483},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4077133536338806},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.28206467628479004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2641238272190094}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/biovis.2012.6378590","is_oa":false,"landing_page_url":"https://doi.org/10.1109/biovis.2012.6378590","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE Symposium on Biological Data Visualization (BioVis)","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.295.5729","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.295.5729","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.informatik.uni-rostock.de/~malub/pub/12/heteroguidance/12_LMSSU_heterogeneity.pdf","raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:publications/f62697d4-0bae-4052-90b2-5a041eba86eb","is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/f62697d4-0bae-4052-90b2-5a041eba86eb","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Luboschik, M, Maus, C, Schulz, H-J, Schumann, H & Uhrmacher, A 2012, Heterogeneity-based guidance for exploring multiscale data in systems biology. in J Roerdink & M Hibbs (eds), Proceedings of the IEEE Symposium on Biological Data Visualization BioVis. IEEE, Seattle, USA, pp. 33-40. https://doi.org/10.1109/BioVis.2012.6378590","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320327736","display_name":"Universit\u00e4t Rostock","ror":"https://ror.org/03zdwsf69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1996195324","https://openalex.org/W1998241777","https://openalex.org/W2023568310","https://openalex.org/W2025804044","https://openalex.org/W2035324138","https://openalex.org/W2035714874","https://openalex.org/W2045472572","https://openalex.org/W2061011338","https://openalex.org/W2068359975","https://openalex.org/W2083603459","https://openalex.org/W2101135700","https://openalex.org/W2110042374","https://openalex.org/W2118546156","https://openalex.org/W2121418890","https://openalex.org/W2124192284","https://openalex.org/W2129086861","https://openalex.org/W2136827748","https://openalex.org/W2147353820","https://openalex.org/W2149209690","https://openalex.org/W2152460728","https://openalex.org/W2154382177","https://openalex.org/W2155418451","https://openalex.org/W2169726856","https://openalex.org/W2285670967","https://openalex.org/W3143760913","https://openalex.org/W6678205798","https://openalex.org/W6681488977","https://openalex.org/W6696095240","https://openalex.org/W7001579028"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"In":[0],"systems":[1],"biology,":[2],"analyzing":[3],"simulation":[4,119,143,216],"trajectories":[5,120],"at":[6,29,46,94,145],"multiple":[7,54],"scales":[8,55,91,105,147],"is":[9,188,208],"a":[10,22,71,95,173,219],"common":[11],"approach":[12,180,207],"when":[13],"subtle,":[14],"detailed":[15],"behavior":[16,20,156],"and":[17,43,165,197],"fundamental,":[18],"overall":[19],"of":[21,35,53,62,67,102,118,127,214,218],"modeled":[23],"system":[24],"are":[25],"to":[26,41,99,107,122,141,148,190],"be":[27,100,108,204],"investigated":[28],"the":[30,50,60,84,116,125,128,142,169,194],"same":[31],"time.":[32],"A":[33],"variety":[34],"multiscale":[36,174],"visualization":[37],"techniques":[38],"provide":[39],"solutions":[40],"handle":[42],"depict":[44],"data":[45,87,129,144,171,196],"different":[47,138],"scales.":[48,132,160],"Yet":[49],"mere":[51],"existence":[52,61],"does":[56],"not":[57,76],"necessarily":[58],"imply":[59],"additional":[63,201],"information":[64,123,202],"on":[65,70,157,185],"each":[66],"them:":[68],"Data":[69],"more":[72,89,158],"fine-grained":[73,159],"scale":[74],"may":[75],"always":[77],"yield":[78],"new":[79],"details,":[80],"but":[81],"instead":[82],"reflect":[83],"already":[85],"known":[86],"from":[88],"coarse-grained":[90],"-":[92],"just":[93],"higher":[96],"resolution.":[97],"Nevertheless,":[98],"sure":[101],"this,":[103],"all":[104],"have":[106],"explored.":[109],"We":[110,161],"address":[111],"this":[112,134],"issue":[113],"by":[114,210],"guiding":[115],"exploration":[117],"according":[121],"about":[124],"deviation":[126],"between":[130],"subsequent":[131,146],"For":[133],"purpose,":[135],"we":[136],"apply":[137],"dissimilarity":[139],"measures":[140],"automatically":[149],"discern":[150],"heterogeneous":[151],"regions":[152,164],"that":[153],"exhibit":[154],"deviating":[155],"mark":[162],"these":[163],"display":[166],"them":[167],"alongside":[168],"actual":[170],"in":[172],"visualization.":[175],"By":[176],"doing":[177],"so,":[178,199],"our":[179],"provides":[181],"valuable":[182],"visual":[183],"cues":[184],"whether":[186],"it":[187],"worthwhile":[189],"drill-down":[191],"further":[192],"into":[193],"multi-scale":[195],"if":[198],"where":[200],"can":[203],"expected.":[205],"Our":[206],"demonstrated":[209],"an":[211],"exploratory":[212],"walk-through":[213],"stochastic":[215],"results":[217],"biochemical":[220],"reaction":[221],"network.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}