{"id":"https://openalex.org/W4312832752","doi":"https://doi.org/10.1109/biorob52689.2022.9925484","title":"RobHeart: Soft Robot for Heart-Like Volumetric Stress on Seeded Cardiac Cells","display_name":"RobHeart: Soft Robot for Heart-Like Volumetric Stress on Seeded Cardiac Cells","publication_year":2022,"publication_date":"2022-08-21","ids":{"openalex":"https://openalex.org/W4312832752","doi":"https://doi.org/10.1109/biorob52689.2022.9925484"},"language":"en","primary_location":{"id":"doi:10.1109/biorob52689.2022.9925484","is_oa":false,"landing_page_url":"https://doi.org/10.1109/biorob52689.2022.9925484","pdf_url":null,"source":{"id":"https://openalex.org/S4363608367","display_name":"2022 9th IEEE RAS/EMBS International Conference for Biomedical Robotics and Biomechatronics (BioRob)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 9th IEEE RAS/EMBS International Conference for Biomedical Robotics and Biomechatronics (BioRob)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101782553","display_name":"Alberto Villani","orcid":"https://orcid.org/0000-0003-2331-7492"},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Villani","raw_affiliation_strings":["University of Siena,Department of Information Engineering and Mathematics&#x0027;,Siena,Italy,I-53100"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Siena,Department of Information Engineering and Mathematics&#x0027;,Siena,Italy,I-53100","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007988989","display_name":"Giulio Ciucci","orcid":null},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulio Ciucci","raw_affiliation_strings":["Molecular Cardiology, International Centre for Genetic Engineering and Biotechnology,Trieste,Italy","Molecular Cardiology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology, International Centre for Genetic Engineering and Biotechnology,Trieste,Italy","institution_ids":["https://openalex.org/I91080651"]},{"raw_affiliation_string":"Molecular Cardiology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043540285","display_name":"Andrea Colliva","orcid":"https://orcid.org/0009-0001-4378-6248"},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Colliva","raw_affiliation_strings":["Molecular Cardiology, International Centre for Genetic Engineering and Biotechnology,Trieste,Italy","Molecular Cardiology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology, International Centre for Genetic Engineering and Biotechnology,Trieste,Italy","institution_ids":["https://openalex.org/I91080651"]},{"raw_affiliation_string":"Molecular Cardiology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020066004","display_name":"Sara Marullo","orcid":"https://orcid.org/0000-0003-1136-1736"},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Marullo","raw_affiliation_strings":["University of Siena,Department of Information Engineering and Mathematics&#x0027;,Siena,Italy,I-53100"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Siena,Department of Information Engineering and Mathematics&#x0027;,Siena,Italy,I-53100","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022450686","display_name":"Serena Zacchigna","orcid":"https://orcid.org/0000-0001-6705-3076"},"institutions":[{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Serena Zacchigna","raw_affiliation_strings":["Molecular Cardiology, International Centre for Genetic Engineering and Biotechnology,Trieste,Italy","Molecular Cardiology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy","Department of Medicine, Surgery and Health Sciences and Cardiovascular Department, Centre for Translational Cardiology, Azienda Sanitaria Universitaria Integrata Trieste, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology, International Centre for Genetic Engineering and Biotechnology,Trieste,Italy","institution_ids":["https://openalex.org/I91080651"]},{"raw_affiliation_string":"Molecular Cardiology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]},{"raw_affiliation_string":"Department of Medicine, Surgery and Health Sciences and Cardiovascular Department, Centre for Translational Cardiology, Azienda Sanitaria Universitaria Integrata Trieste, Trieste, Italy","institution_ids":["https://openalex.org/I4210164020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056137946","display_name":"Domenico Prattichizzo","orcid":"https://orcid.org/0000-0001-9051-9698"},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]},{"id":"https://openalex.org/I30771326","display_name":"Italian Institute of Technology","ror":"https://ror.org/042t93s57","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenico Prattichizzo","raw_affiliation_strings":["University of Siena,Department of Information Engineering and Mathematics&#x0027;,Siena,Italy,I-53100","Department of Advanced Robotics, Istituto Italiano di Tecnologia, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Siena,Department of Information Engineering and Mathematics&#x0027;,Siena,Italy,I-53100","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Department of Advanced Robotics, Istituto Italiano di Tecnologia, Genova, Italy","institution_ids":["https://openalex.org/I30771326"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3194,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.51987401,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"44","issue":null,"first_page":"01","last_page":"08"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.6659324169158936},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"Biocompatibility","score":0.5665385127067566},{"id":"https://openalex.org/keywords/silicone-rubber","display_name":"Silicone rubber","score":0.5574681758880615},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5469473004341125},{"id":"https://openalex.org/keywords/robot-end-effector","display_name":"Robot end effector","score":0.5229842662811279},{"id":"https://openalex.org/keywords/robot","display_name":"Robot","score":0.49870920181274414},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4944291114807129},{"id":"https://openalex.org/keywords/soft-robotics","display_name":"Soft robotics","score":0.4637596607208252},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4455453157424927},{"id":"https://openalex.org/keywords/heart-cells","display_name":"Heart cells","score":0.4449378252029419},{"id":"https://openalex.org/keywords/silicone","display_name":"Silicone","score":0.4435684084892273},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.2406332790851593},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2197260558605194},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.20709428191184998},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.18296292424201965},{"id":"https://openalex.org/keywords/myocyte","display_name":"Myocyte","score":0.1752343475818634},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.1253317892551422}],"concepts":[{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.6659324169158936},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.5665385127067566},{"id":"https://openalex.org/C2776290925","wikidata":"https://www.wikidata.org/wiki/Q4115245","display_name":"Silicone rubber","level":2,"score":0.5574681758880615},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5469473004341125},{"id":"https://openalex.org/C8652668","wikidata":"https://www.wikidata.org/wiki/Q1340324","display_name":"Robot end effector","level":3,"score":0.5229842662811279},{"id":"https://openalex.org/C90509273","wikidata":"https://www.wikidata.org/wiki/Q11012","display_name":"Robot","level":2,"score":0.49870920181274414},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4944291114807129},{"id":"https://openalex.org/C2776058767","wikidata":"https://www.wikidata.org/wiki/Q24327151","display_name":"Soft robotics","level":3,"score":0.4637596607208252},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4455453157424927},{"id":"https://openalex.org/C2909258576","wikidata":"https://www.wikidata.org/wiki/Q88151925","display_name":"Heart cells","level":3,"score":0.4449378252029419},{"id":"https://openalex.org/C2779769944","wikidata":"https://www.wikidata.org/wiki/Q146439","display_name":"Silicone","level":2,"score":0.4435684084892273},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2406332790851593},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2197260558605194},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.20709428191184998},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.18296292424201965},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.1752343475818634},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1253317892551422},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/biorob52689.2022.9925484","is_oa":false,"landing_page_url":"https://doi.org/10.1109/biorob52689.2022.9925484","pdf_url":null,"source":{"id":"https://openalex.org/S4363608367","display_name":"2022 9th IEEE RAS/EMBS International Conference for Biomedical Robotics and Biomechatronics (BioRob)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 9th IEEE RAS/EMBS International Conference for Biomedical Robotics and Biomechatronics (BioRob)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1960623882","https://openalex.org/W1988248351","https://openalex.org/W1989024845","https://openalex.org/W1994233268","https://openalex.org/W1998706509","https://openalex.org/W2022352603","https://openalex.org/W2044734808","https://openalex.org/W2064922052","https://openalex.org/W2082358669","https://openalex.org/W2113654169","https://openalex.org/W2113849634","https://openalex.org/W2142275056","https://openalex.org/W2155051977","https://openalex.org/W2160202281","https://openalex.org/W2291401466","https://openalex.org/W2417373107","https://openalex.org/W2515634125","https://openalex.org/W2560150837","https://openalex.org/W2741613346","https://openalex.org/W2774104907","https://openalex.org/W2794489501","https://openalex.org/W2914507740","https://openalex.org/W2915926893","https://openalex.org/W2971254079","https://openalex.org/W3015061870","https://openalex.org/W3083462958","https://openalex.org/W4236881204"],"related_works":["https://openalex.org/W2789938994","https://openalex.org/W1598329078","https://openalex.org/W2353141234","https://openalex.org/W1996898083","https://openalex.org/W2083557144","https://openalex.org/W1920348400","https://openalex.org/W2350606714","https://openalex.org/W1982980711","https://openalex.org/W2006509171","https://openalex.org/W2370429222"],"abstract_inverted_index":{"Mechanical":[0],"stress":[1,119],"plays":[2],"a":[3,97],"vital":[4],"role":[5],"in":[6,16,30],"the":[7,68,85],"regulation":[8],"of":[9,67,87],"several":[10,35,51],"cellular":[11],"processes.":[12],"To":[13],"reduce":[14],"uncertainties":[15],"observations,":[17],"biological":[18],"research":[19],"on":[20,27,42,129],"cells":[21,28,43,130],"is":[22],"usually":[23],"conducted":[24],"in-vitro,":[25],"i.e.":[26],"grown":[29],"highly-controlled":[31],"lab":[32],"environments.":[33],"Although":[34],"devices":[36],"able":[37],"to":[38,61,115],"reproduce":[39],"proper":[40],"stimuli":[41],"have":[44],"been":[45],"recently":[46],"proposed,":[47],"still":[48],"there":[49],"are":[50,131],"open":[52],"challenges.":[53],"Heart":[54],"cells,":[55],"for":[56,71],"example,":[57],"require":[58],"millimetric":[59],"wells":[60,70],"survive":[62],"and":[63,79,107,112,117,126],"grow":[64],"in-vitro.":[65],"Size":[66],"culture":[69],"medium-throughput":[72],"screening,":[73],"integrability":[74],"requirements":[75],"with":[76,81,101],"laboratory":[77],"techniques,":[78],"biocompatibility":[80],"living":[82],"organisms":[83],"make":[84],"development":[86],"suitable":[88],"end-effectors":[89],"complex.":[90],"In":[91],"this":[92],"work,":[93],"we":[94],"present":[95],"RobHeart,":[96],"modular":[98],"soft":[99],"robot":[100],"deformable":[102],"end-effectors,":[103],"fabricated":[104],"by":[105],"layering":[106],"molding":[108],"bi-component":[109],"silicone":[110],"rubber,":[111],"specifically":[113],"designed":[114],"seed":[116],"3D":[118],"heart":[120],"cells.":[121],"RobHeart":[122],"design,":[123],"fabrication,":[124],"validation":[125],"preliminary":[127],"tests":[128],"presented.":[132]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
