{"id":"https://openalex.org/W4405709795","doi":"https://doi.org/10.1109/biocas61083.2024.10798316","title":"An Equivalent Circuit Model of Living Myocardial Slice Cultured on Microelectrode Array with in-vitro Experimental Validations","display_name":"An Equivalent Circuit Model of Living Myocardial Slice Cultured on Microelectrode Array with in-vitro Experimental Validations","publication_year":2024,"publication_date":"2024-10-24","ids":{"openalex":"https://openalex.org/W4405709795","doi":"https://doi.org/10.1109/biocas61083.2024.10798316"},"language":"en","primary_location":{"id":"doi:10.1109/biocas61083.2024.10798316","is_oa":false,"landing_page_url":"https://doi.org/10.1109/biocas61083.2024.10798316","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE Biomedical Circuits and Systems Conference (BioCAS)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037681456","display_name":"Rui Guan","orcid":"https://orcid.org/0000-0001-7522-6221"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rui Guan","raw_affiliation_strings":["Delft University of Technology,Department of Microelectronics,Delft,the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delft University of Technology,Department of Microelectronics,Delft,the Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101993424","display_name":"Tao Shen","orcid":"https://orcid.org/0000-0002-6129-3092"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tao Shen","raw_affiliation_strings":["Delft University of Technology,Department of Microelectronics,Delft,the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delft University of Technology,Department of Microelectronics,Delft,the Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112425959","display_name":"Paul Knops","orcid":null},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Paul Knops","raw_affiliation_strings":["Erasmus University Medical Center,Department of Cardiology,Rotterdam,the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erasmus University Medical Center,Department of Cardiology,Rotterdam,the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102985416","display_name":"Yannick J.H.J. Taverne","orcid":"https://orcid.org/0000-0002-1030-2198"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Yannick J. H. J. Taverne","raw_affiliation_strings":["Erasmus University Medical Center,Department of Cardiothoracic Surgery,Rotterdam,the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erasmus University Medical Center,Department of Cardiothoracic Surgery,Rotterdam,the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014398858","display_name":"Zhenyu Gao","orcid":"https://orcid.org/0000-0002-4979-2366"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Zhenyu Gao","raw_affiliation_strings":["Erasmus University Medical Center,Department of Neuroscience,Rotterdam,the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erasmus University Medical Center,Department of Neuroscience,Rotterdam,the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026328471","display_name":"Sijun Du","orcid":"https://orcid.org/0000-0001-6238-4423"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sijun Du","raw_affiliation_strings":["Delft University of Technology,Department of Microelectronics,Delft,the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delft University of Technology,Department of Microelectronics,Delft,the Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074435632","display_name":"Robert van Veldhoven","orcid":"https://orcid.org/0000-0001-7815-2010"},"institutions":[{"id":"https://openalex.org/I109147379","display_name":"NXP (Netherlands)","ror":"https://ror.org/059be4e97","country_code":"NL","type":"company","lineage":["https://openalex.org/I109147379"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Robert van Veldhoven","raw_affiliation_strings":["NXP Semiconductors,Eindhoven,the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NXP Semiconductors,Eindhoven,the Netherlands","institution_ids":["https://openalex.org/I109147379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042927743","display_name":"Natasja M.S. de Groot","orcid":"https://orcid.org/0000-0002-0259-6691"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Natasja M. S. De Groot","raw_affiliation_strings":["Erasmus University Medical Center,Department of Cardiology,Rotterdam,the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erasmus University Medical Center,Department of Cardiology,Rotterdam,the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087001469","display_name":"F. Widdershoven","orcid":null},"institutions":[{"id":"https://openalex.org/I109147379","display_name":"NXP (Netherlands)","ror":"https://ror.org/059be4e97","country_code":"NL","type":"company","lineage":["https://openalex.org/I109147379"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frans Widdershoven","raw_affiliation_strings":["NXP Semiconductors,Eindhoven,the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NXP Semiconductors,Eindhoven,the Netherlands","institution_ids":["https://openalex.org/I109147379"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9825999736785889,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9825999736785889,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.97079998254776,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10783","display_name":"Additive Manufacturing and 3D Printing Technologies","score":0.9546999931335449,"subfield":{"id":"https://openalex.org/subfields/2203","display_name":"Automotive Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microelectrode","display_name":"Microelectrode","score":0.7821892499923706},{"id":"https://openalex.org/keywords/multielectrode-array","display_name":"Multielectrode array","score":0.6607348322868347},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.4926775097846985},{"id":"https://openalex.org/keywords/equivalent-circuit","display_name":"Equivalent circuit","score":0.47785326838493347},{"id":"https://openalex.org/keywords/wafer","display_name":"Wafer","score":0.4630586802959442},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.418315589427948},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38107675313949585},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.34694698452949524},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.323162317276001},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.28662359714508057},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.27308189868927},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.22435322403907776},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.210239976644516},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.12473538517951965},{"id":"https://openalex.org/keywords/voltage","display_name":"Voltage","score":0.09612220525741577}],"concepts":[{"id":"https://openalex.org/C111670793","wikidata":"https://www.wikidata.org/wiki/Q16979465","display_name":"Microelectrode","level":3,"score":0.7821892499923706},{"id":"https://openalex.org/C95967509","wikidata":"https://www.wikidata.org/wiki/Q1952355","display_name":"Multielectrode array","level":4,"score":0.6607348322868347},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4926775097846985},{"id":"https://openalex.org/C23572009","wikidata":"https://www.wikidata.org/wiki/Q964981","display_name":"Equivalent circuit","level":3,"score":0.47785326838493347},{"id":"https://openalex.org/C160671074","wikidata":"https://www.wikidata.org/wiki/Q267131","display_name":"Wafer","level":2,"score":0.4630586802959442},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.418315589427948},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38107675313949585},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34694698452949524},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.323162317276001},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.28662359714508057},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.27308189868927},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22435322403907776},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.210239976644516},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.12473538517951965},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.09612220525741577},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/biocas61083.2024.10798316","is_oa":false,"landing_page_url":"https://doi.org/10.1109/biocas61083.2024.10798316","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE Biomedical Circuits and Systems Conference (BioCAS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307110","display_name":"Delta","ror":"https://ror.org/03g9c1e75"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1858858096","https://openalex.org/W1987345946","https://openalex.org/W2030067432","https://openalex.org/W2057759785","https://openalex.org/W2104749146","https://openalex.org/W2105870814","https://openalex.org/W2118931545","https://openalex.org/W2126012359","https://openalex.org/W2141111805","https://openalex.org/W2155347215","https://openalex.org/W2159318368","https://openalex.org/W2160235532","https://openalex.org/W2171573199","https://openalex.org/W2465718101","https://openalex.org/W2760952345","https://openalex.org/W2922159564","https://openalex.org/W2980630331","https://openalex.org/W2998521009","https://openalex.org/W3014144834","https://openalex.org/W4316041334"],"related_works":["https://openalex.org/W2061877343","https://openalex.org/W2028205923","https://openalex.org/W2381760774","https://openalex.org/W2037345099","https://openalex.org/W2964977587","https://openalex.org/W4386697944","https://openalex.org/W2417316355","https://openalex.org/W2768056422","https://openalex.org/W2162019548","https://openalex.org/W2354662944"],"abstract_inverted_index":{"In":[0],"this":[1],"paper,":[2],"we":[3],"present":[4],"an":[5],"equivalent":[6],"circuit":[7],"model":[8,37,80],"that":[9],"integrates":[10],"a":[11,18,25],"living":[12],"myocardial":[13],"slice":[14],"(LMS)":[15],"cultured":[16],"on":[17,74],"microelectrode":[19],"array":[20],"(MEA)":[21],"to":[22,45,70],"effectively":[23],"simulates":[24],"heart-on-a-chip":[26],"(HoC)":[27],"within":[28],"Electronic":[29],"Design":[30],"Automation":[31],"(EDA)":[32],"software.":[33],"The":[34,79],"cardiac":[35,99],"fiber":[36],"consists":[38],"of":[39],"cardiomyocytes":[40],"interconnected":[41],"by":[42],"gap":[43,62],"junctions":[44],"simulate":[46],"the":[47,53],"action":[48],"potential":[49,77,93],"(AP)":[50],"conduction":[51],"in":[52,85,98],"longitudinal":[54],"direction.":[55],"We":[56],"systematically":[57],"explored":[58],"several":[59],"parameters,":[60],"including":[61],"junction":[63],"resistors,":[64,66],"seal":[65],"and":[67],"electrode":[68],"diameters,":[69],"assess":[71],"their":[72],"effects":[73],"local":[75],"field":[76],"(LFP).":[78],"accuracy":[81],"was":[82],"validated":[83],"through":[84],"vitro":[86],"experiments":[87],"using":[88],"mouse":[89],"LMS,":[90],"confirming":[91],"its":[92],"for":[94],"guiding":[95],"HoC":[96],"design":[97],"research.":[100]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
