{"id":"https://openalex.org/W4200378755","doi":"https://doi.org/10.1109/biocas49922.2021.9644934","title":"A Biologically-Informed Computational Framework for Pathway-Specific Spiking Patterns Generation and Efficacy Evaluation in Retinal Neurostimulators","display_name":"A Biologically-Informed Computational Framework for Pathway-Specific Spiking Patterns Generation and Efficacy Evaluation in Retinal Neurostimulators","publication_year":2021,"publication_date":"2021-10-07","ids":{"openalex":"https://openalex.org/W4200378755","doi":"https://doi.org/10.1109/biocas49922.2021.9644934"},"language":"en","primary_location":{"id":"doi:10.1109/biocas49922.2021.9644934","is_oa":false,"landing_page_url":"https://doi.org/10.1109/biocas49922.2021.9644934","pdf_url":null,"source":{"id":"https://openalex.org/S4363608526","display_name":"2021 IEEE Biomedical Circuits and Systems Conference (BioCAS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE Biomedical Circuits and Systems Conference (BioCAS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018041628","display_name":"Tayebeh Yousefi","orcid":"https://orcid.org/0000-0002-0600-8957"},"institutions":[{"id":"https://openalex.org/I192455969","display_name":"York University","ror":"https://ror.org/05fq50484","country_code":"CA","type":"education","lineage":["https://openalex.org/I192455969"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Tayebeh Yousefi","raw_affiliation_strings":["York University, Canada"],"affiliations":[{"raw_affiliation_string":"York University, Canada","institution_ids":["https://openalex.org/I192455969"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062337024","display_name":"Hossein Kassiri","orcid":"https://orcid.org/0000-0002-8220-1986"},"institutions":[{"id":"https://openalex.org/I192455969","display_name":"York University","ror":"https://ror.org/05fq50484","country_code":"CA","type":"education","lineage":["https://openalex.org/I192455969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hossein Kassiri","raw_affiliation_strings":["York University, Canada"],"affiliations":[{"raw_affiliation_string":"York University, Canada","institution_ids":["https://openalex.org/I192455969"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018041628"],"corresponding_institution_ids":["https://openalex.org/I192455969"],"apc_list":null,"apc_paid":null,"fwci":0.9615,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.70967742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"28","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optogenetics","display_name":"Optogenetics","score":0.7971413135528564},{"id":"https://openalex.org/keywords/stimulus","display_name":"Stimulus (psychology)","score":0.6606978178024292},{"id":"https://openalex.org/keywords/visual-prosthesis","display_name":"Visual prosthesis","score":0.5559337139129639},{"id":"https://openalex.org/keywords/retinal","display_name":"Retinal","score":0.5554900765419006},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5525835752487183},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5414199829101562},{"id":"https://openalex.org/keywords/retina","display_name":"Retina","score":0.499431848526001},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.4684854745864868},{"id":"https://openalex.org/keywords/perception","display_name":"Perception","score":0.447780042886734},{"id":"https://openalex.org/keywords/visual-perception","display_name":"Visual perception","score":0.4471646547317505},{"id":"https://openalex.org/keywords/retinal-implant","display_name":"Retinal implant","score":0.4303383529186249},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19059792160987854},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.10805237293243408}],"concepts":[{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.7971413135528564},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.6606978178024292},{"id":"https://openalex.org/C2778560042","wikidata":"https://www.wikidata.org/wiki/Q540043","display_name":"Visual prosthesis","level":3,"score":0.5559337139129639},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5554900765419006},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5525835752487183},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5414199829101562},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.499431848526001},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4684854745864868},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.447780042886734},{"id":"https://openalex.org/C178253425","wikidata":"https://www.wikidata.org/wiki/Q162668","display_name":"Visual perception","level":3,"score":0.4471646547317505},{"id":"https://openalex.org/C158383150","wikidata":"https://www.wikidata.org/wiki/Q3149439","display_name":"Retinal implant","level":3,"score":0.4303383529186249},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19059792160987854},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.10805237293243408},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/biocas49922.2021.9644934","is_oa":false,"landing_page_url":"https://doi.org/10.1109/biocas49922.2021.9644934","pdf_url":null,"source":{"id":"https://openalex.org/S4363608526","display_name":"2021 IEEE Biomedical Circuits and Systems Conference (BioCAS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE Biomedical Circuits and Systems Conference (BioCAS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1978023046","https://openalex.org/W1995001599","https://openalex.org/W2058082904","https://openalex.org/W2069519142","https://openalex.org/W2106937721","https://openalex.org/W2185459228","https://openalex.org/W2401981424","https://openalex.org/W2950242659","https://openalex.org/W2952153146","https://openalex.org/W2952502476","https://openalex.org/W3016004439","https://openalex.org/W3018821012","https://openalex.org/W3088863608","https://openalex.org/W3094054138","https://openalex.org/W3103537415","https://openalex.org/W3137926359","https://openalex.org/W4211089624","https://openalex.org/W6686604056"],"related_works":["https://openalex.org/W2985787306","https://openalex.org/W1983632939","https://openalex.org/W2027547973","https://openalex.org/W4388938748","https://openalex.org/W2476154117","https://openalex.org/W2568687041","https://openalex.org/W2189099429","https://openalex.org/W2271740829","https://openalex.org/W2113792828","https://openalex.org/W2982939032"],"abstract_inverted_index":{"Precise":[0],"control":[1,54],"of":[2,6,12,36,88,110,115,141,153,173],"neuronal":[3],"pathways":[4],"is":[5,45,50,74],"critical":[7],"importance":[8],"for":[9,40,56,97],"the":[10,86,89,95,98,107,132,136,154,168],"efficacy":[11],"neuro-modulation":[13],"prostheses":[14],"designed":[15],"to":[16,52,63,77,85,146],"restore":[17],"vision":[18],"in":[19,94,126,151,176],"patients":[20],"with":[21,83],"retinal":[22,60],"degeneration.":[23],"In":[24],"this":[25,177],"paper,":[26],"a":[27,148],"biologically-informed":[28],"computational":[29],"framework":[30],"that":[31,106],"enables":[32],"generation":[33],"and":[34,80,135,161],"optimization":[35],"pathway-specific":[37],"spiking":[38],"patterns":[39],"retina":[41],"ganglion":[42],"cells":[43],"(RGCs)":[44],"presented.":[46],"The":[47,72,139,171],"developed":[48,169],"model":[49,73],"used":[51,76],"generate":[53],"signals":[55],"an":[57],"implantable":[58],"optical":[59,81,118,160,174],"neurostimulator":[61],"device":[62],"modulate":[64],"genetically-modified":[65],"RGCs,":[66],"thus":[67],"enable":[68],"cell-type-specific":[69],"neural":[70],"excitation.":[71],"also":[75,165],"compare":[78],"electrical":[79,124,162],"neuro-stimulations":[82],"respect":[84],"quality":[87,158],"visual":[90,100,133,156],"perception":[91,157],"they":[92],"induce":[93],"brain":[96],"same":[99],"stimulus.":[101],"Our":[102],"simulation":[103,182],"results":[104],"show":[105],"type-specific":[108],"activation":[109],"RGCs":[111],"(an":[112],"inherent":[113],"advantage":[114],"optogenetics)":[116],"makes":[117],"stimulation":[119,125,175],"significantly":[120],"more":[121],"effective":[122],"than":[123],"achieving":[127],"high":[128],"structural":[129],"similarity":[130],"between":[131],"stimulus":[134],"estimated":[137],"perception.":[138],"effect":[140],"increasing":[142],"/-Lelectrode//-LLED":[143],"array":[144],"density":[145],"achieve":[147],"better":[149],"performance":[150],"terms":[152],"induced":[155],"by":[159],"stimulations":[163],"was":[164,179],"studied":[166],"using":[167],"model.":[170],"superiority":[172],"aspect":[178],"demonstrated":[180],"through":[181],"results.":[183]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}