{"id":"https://openalex.org/W2906062827","doi":"https://doi.org/10.1109/biocas.2018.8584699","title":"Embedded Phase-Amplitude Coupling Based Closed-loop Platform for Parkinson's Disease","display_name":"Embedded Phase-Amplitude Coupling Based Closed-loop Platform for Parkinson's Disease","publication_year":2018,"publication_date":"2018-10-01","ids":{"openalex":"https://openalex.org/W2906062827","doi":"https://doi.org/10.1109/biocas.2018.8584699","mag":"2906062827"},"language":"en","primary_location":{"id":"doi:10.1109/biocas.2018.8584699","is_oa":false,"landing_page_url":"https://doi.org/10.1109/biocas.2018.8584699","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018887842","display_name":"Mauro Alexandre","orcid":null},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"M. Alexandre","raw_affiliation_strings":["Imperial College London"],"affiliations":[{"raw_affiliation_string":"Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101847518","display_name":"Song Luan","orcid":"https://orcid.org/0000-0001-9201-6111"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Luan","raw_affiliation_strings":["Imperial College London"],"affiliations":[{"raw_affiliation_string":"Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035628923","display_name":"Zolt\u00e1n Mari","orcid":"https://orcid.org/0000-0003-0356-9879"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Mari","raw_affiliation_strings":["Johns Hopkins University"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043335263","display_name":"William S. Anderson","orcid":"https://orcid.org/0000-0003-0958-050X"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. S. Anderson","raw_affiliation_strings":["Johns Hopkins University"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010892998","display_name":"Yousef Salimpour","orcid":"https://orcid.org/0000-0002-7546-004X"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Salimpour","raw_affiliation_strings":["Johns Hopkins University"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017596402","display_name":"Timothy G. Constandinou","orcid":"https://orcid.org/0000-0001-9778-1162"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. G. Constandinou","raw_affiliation_strings":["Imperial College London"],"affiliations":[{"raw_affiliation_string":"Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061329687","display_name":"L\u00e1szl\u00f3 Grand","orcid":"https://orcid.org/0000-0001-5391-3266"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. B. Grand","raw_affiliation_strings":["Johns Hopkins University"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5018887842"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":0.1664,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.57586009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"Deep brain stimulation","score":0.7953852415084839},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.5481952428817749},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4809514880180359},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"Neuromodulation","score":0.45761552453041077},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.3808770179748535},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3729228377342224},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.33632147312164307},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.2886613607406616},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.21429499983787537}],"concepts":[{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.7953852415084839},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5481952428817749},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4809514880180359},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.45761552453041077},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3808770179748535},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3729228377342224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33632147312164307},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.2886613607406616},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.21429499983787537},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/biocas.2018.8584699","is_oa":false,"landing_page_url":"https://doi.org/10.1109/biocas.2018.8584699","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)","raw_type":"proceedings-article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/58746","is_oa":false,"landing_page_url":"http://hdl.handle.net/10044/1/58746","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Biomedical Circuits and Systems (BioCAS) Conference","raw_type":"Conference Paper"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1479935944","https://openalex.org/W1872235122","https://openalex.org/W1967428268","https://openalex.org/W1987095365","https://openalex.org/W2062924781","https://openalex.org/W2073658109","https://openalex.org/W2085092712","https://openalex.org/W2112575160","https://openalex.org/W2115810652","https://openalex.org/W2150135821","https://openalex.org/W2165730296","https://openalex.org/W2329059023","https://openalex.org/W2465369861","https://openalex.org/W6671979896"],"related_works":["https://openalex.org/W2790156845","https://openalex.org/W2897125999","https://openalex.org/W3109080428","https://openalex.org/W1978747821","https://openalex.org/W2531482060","https://openalex.org/W4386070499","https://openalex.org/W2414205034","https://openalex.org/W2034919592","https://openalex.org/W2914511819","https://openalex.org/W2771365127"],"abstract_inverted_index":{"Deep":[0],"Brain":[1],"Stimulation":[2],"(DBS)":[3],"is":[4,147],"a":[5,82,105],"widely":[6],"used":[7],"clinical":[8,167],"therapeutic":[9,73],"modality":[10],"to":[11,80,149],"treat":[12],"Parkinsons":[13,47],"disease":[14,48],"refractory":[15],"symptoms":[16],"and":[17,34,71,85,134],"complications":[18],"of":[19,46,55,75,99,138],"levodopa":[20],"therapy.":[21],"Currently":[22],"available":[23],"DBSsystems":[24],"use":[25],"continuous,":[26],"open-loop":[27],"stimulation":[28],"strategies.":[29],"It":[30],"might":[31],"be":[32],"redundant":[33],"we":[35,111,159],"could":[36],"extend":[37],"the":[38,62,72,91,97,100,162],"battery":[39,163],"life":[40],"otherwise.":[41],"Recently,":[42],"robust":[43],"electrophysiological":[44],"signatures":[45],"have":[49],"been":[50],"characterized":[51],"in":[52,61,108],"motor":[53],"cortex":[54],"patients":[56],"undergoing":[57],"DBS":[58,76,156],"surgery.":[59],"Reductions":[60],"beta-gamma":[63],"Phase-Amplitude":[64],"coupling":[65],"(PAC)":[66],"correlated":[67],"with":[68],"symptom":[69],"improvement,":[70],"effects":[74],"itself.":[77],"We":[78,125],"aim":[79],"develop":[81],"miniature,":[83],"implantable":[84],"adaptive":[86],"system,":[87],"which":[88],"only":[89],"stimulates":[90],"neural":[92],"target,":[93],"when":[94],"triggered":[95],"by":[96,116],"output":[98],"appropriate":[101],"PAC":[102,114,139],"algorithm.":[103],"As":[104],"first":[106],"step,":[107],"this":[109],"paper":[110],"compare":[112],"published":[113],"algorithms":[115],"using":[117],"human":[118],"data":[119],"intra-operatively":[120],"recorded":[121],"from":[122],"Parkinsonian":[123],"patients.":[124],"then":[126],"introduce":[127],"IIR":[128],"masking":[129],"for":[130,141],"later":[131],"achieving":[132],"fast":[133],"low-power":[135],"FPGA":[136],"implementation":[137],"mapping":[140],"intra-operative":[142],"studies.":[143],"Our":[144],"closed-loop":[145],"application":[146],"expected":[148],"consume":[150],"significantly":[151],"less":[152],"power":[153],"than":[154],"current":[155],"systems,":[157],"therefore":[158],"can":[160],"increase":[161],"life,":[164],"without":[165],"compromising":[166],"benefits.":[168]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-25T21:42:39.735039","created_date":"2025-10-10T00:00:00"}