{"id":"https://openalex.org/W1978660457","doi":"https://doi.org/10.1109/bigdata.2014.7004389","title":"Towards integrating the detection of genetic variants into an in-memory database","display_name":"Towards integrating the detection of genetic variants into an in-memory database","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1978660457","doi":"https://doi.org/10.1109/bigdata.2014.7004389","mag":"1978660457"},"language":"en","primary_location":{"id":"doi:10.1109/bigdata.2014.7004389","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bigdata.2014.7004389","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE International Conference on Big Data (Big Data)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049206057","display_name":"Cindy F\u00e4hnrich","orcid":null},"institutions":[{"id":"https://openalex.org/I143288331","display_name":"Hasso Plattner Institute","ror":"https://ror.org/058rn5r42","country_code":"DE","type":"facility","lineage":["https://openalex.org/I143288331","https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cindy Fahnrich","raw_affiliation_strings":["Hasso Plattner Institute, Enterprise Platform and Integration Concepts, Potsdam, Germany","Hasso Plattner Institute, Enterprise Platform and Integration Concepts August-Bebel-Str. 88, 14482 Potsdam, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hasso Plattner Institute, Enterprise Platform and Integration Concepts, Potsdam, Germany","institution_ids":["https://openalex.org/I143288331"]},{"raw_affiliation_string":"Hasso Plattner Institute, Enterprise Platform and Integration Concepts August-Bebel-Str. 88, 14482 Potsdam, Germany","institution_ids":["https://openalex.org/I143288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053012847","display_name":"Matthieu-P. Schapranow","orcid":"https://orcid.org/0000-0001-6601-2942"},"institutions":[{"id":"https://openalex.org/I143288331","display_name":"Hasso Plattner Institute","ror":"https://ror.org/058rn5r42","country_code":"DE","type":"facility","lineage":["https://openalex.org/I143288331","https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthieu-P. Schapranow","raw_affiliation_strings":["Hasso Plattner Institute, Enterprise Platform and Integration Concepts, Potsdam, Germany","Hasso Plattner Institute, Enterprise Platform and Integration Concepts August-Bebel-Str. 88, 14482 Potsdam, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hasso Plattner Institute, Enterprise Platform and Integration Concepts, Potsdam, Germany","institution_ids":["https://openalex.org/I143288331"]},{"raw_affiliation_string":"Hasso Plattner Institute, Enterprise Platform and Integration Concepts August-Bebel-Str. 88, 14482 Potsdam, Germany","institution_ids":["https://openalex.org/I143288331"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035480309","display_name":"Hasso Plattner","orcid":null},"institutions":[{"id":"https://openalex.org/I143288331","display_name":"Hasso Plattner Institute","ror":"https://ror.org/058rn5r42","country_code":"DE","type":"facility","lineage":["https://openalex.org/I143288331","https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hasso Plattner","raw_affiliation_strings":["Hasso Plattner Institute, Enterprise Platform and Integration Concepts, Potsdam, Germany","Hasso Plattner Institute, Enterprise Platform and Integration Concepts August-Bebel-Str. 88, 14482 Potsdam, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hasso Plattner Institute, Enterprise Platform and Integration Concepts, Potsdam, Germany","institution_ids":["https://openalex.org/I143288331"]},{"raw_affiliation_string":"Hasso Plattner Institute, Enterprise Platform and Integration Concepts August-Bebel-Str. 88, 14482 Potsdam, Germany","institution_ids":["https://openalex.org/I143288331"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1423,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52860382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"456","issue":null,"first_page":"27","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11269","display_name":"Algorithms and Data Compression","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.785683274269104},{"id":"https://openalex.org/keywords/exploit","display_name":"Exploit","score":0.644194483757019},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.4551853537559509},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.43330129981040955},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.42016273736953735},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.35033369064331055},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3469699025154114},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11246985197067261},{"id":"https://openalex.org/keywords/operating-system","display_name":"Operating system","score":0.11168032884597778},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10211873054504395},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07968804240226746}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.785683274269104},{"id":"https://openalex.org/C165696696","wikidata":"https://www.wikidata.org/wiki/Q11287","display_name":"Exploit","level":2,"score":0.644194483757019},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.4551853537559509},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.43330129981040955},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.42016273736953735},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.35033369064331055},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3469699025154114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11246985197067261},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.11168032884597778},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10211873054504395},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07968804240226746},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bigdata.2014.7004389","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bigdata.2014.7004389","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE International Conference on Big Data (Big Data)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W605074669","https://openalex.org/W1988345092","https://openalex.org/W2012016911","https://openalex.org/W2058839892","https://openalex.org/W2061680337","https://openalex.org/W2096791516","https://openalex.org/W2108234281","https://openalex.org/W2112113834","https://openalex.org/W2119180969","https://openalex.org/W2124960286","https://openalex.org/W2127515057","https://openalex.org/W2131016694","https://openalex.org/W2148294372","https://openalex.org/W2150871235","https://openalex.org/W2168133698","https://openalex.org/W2168909179","https://openalex.org/W2169276524","https://openalex.org/W2273527300","https://openalex.org/W2305002053","https://openalex.org/W2463048545","https://openalex.org/W2735335013","https://openalex.org/W4230900352","https://openalex.org/W6698193959","https://openalex.org/W6741070640"],"related_works":["https://openalex.org/W1997352593","https://openalex.org/W2143489661","https://openalex.org/W3016573916","https://openalex.org/W4281711902","https://openalex.org/W3206555169","https://openalex.org/W2070581548","https://openalex.org/W3157359833","https://openalex.org/W2413660786","https://openalex.org/W3024317680","https://openalex.org/W1511048503"],"abstract_inverted_index":{"Next-generation":[0],"sequencing":[1,5],"enables":[2],"whole":[3],"genome":[4,86],"within":[6],"a":[7,11,55,99,141],"few":[8],"hours":[9],"at":[10,54],"minimum":[12],"of":[13,50,66,91,98,143],"cost,":[14],"entailing":[15],"advanced":[16],"medical":[17],"applications":[18],"such":[19],"as":[20,35,88],"personalized":[21],"treatments.":[22],"However,":[23],"this":[24,69],"recent":[25],"technology":[26],"imposes":[27],"new":[28],"challenges":[29,76],"to":[30,40,52,140],"alignment":[31],"and":[32,61,107,135],"variant":[33,92],"calling":[34,138],"subsequent":[36],"analysis":[37],"steps.":[38],"Compared":[39],"former":[41],"sequencing,":[42],"both":[43],"must":[44],"deal":[45],"with":[46,122],"an":[47],"increasing":[48],"amount":[49],"data":[51,58,87,105],"process":[53],"significantly":[56],"lower":[57],"quality":[59],"-":[60],"are":[62],"currently":[63],"not":[64],"capable":[65],"that.":[67],"In":[68],"work,":[70],"we":[71],"focus":[72],"on":[73],"addressing":[74],"these":[75],"for":[77,103],"identifying":[78],"Single":[79],"Nucleotide":[80],"Polymorphisms,":[81],"i.e.":[82],"SNP":[83,137],"calling,":[84],"in":[85],"one":[89],"subtask":[90],"calling.":[93],"We":[94],"propose":[95],"the":[96,109,116,123],"application":[97],"column-store":[100],"in-memory":[101],"database":[102],"efficient":[104],"processing":[106],"apply":[108],"statistical":[110],"model":[111],"that":[112,126],"is":[113],"provided":[114],"by":[115],"Genome":[117],"Analysis":[118],"Toolkit's":[119],"UnifiedGenotyper.":[120],"Comparisons":[121],"UnifiedGenotyper":[124],"show":[125],"our":[127],"approach":[128],"can":[129],"exploit":[130],"all":[131],"computational":[132],"resources":[133],"available":[134],"accelerates":[136],"up":[139],"factor":[142],"22x.":[144]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}