{"id":"https://openalex.org/W1978396930","doi":"https://doi.org/10.1109/bicta.2010.5645287","title":"The Mathematical Theory of Integrative Physiology: Application to hippocampus for drug discovery","display_name":"The Mathematical Theory of Integrative Physiology: Application to hippocampus for drug discovery","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W1978396930","doi":"https://doi.org/10.1109/bicta.2010.5645287","mag":"1978396930"},"language":"en","primary_location":{"id":"doi:10.1109/bicta.2010.5645287","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bicta.2010.5645287","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE Fifth International Conference on Bio-Inspired Computing: Theories and Applications (BIC-TA)","raw_type":"proceedings-article"},"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014511314","display_name":"Omar Bennani","orcid":null},"institutions":[{"id":"https://openalex.org/I159885104","display_name":"\u00c9cole Pratique des Hautes \u00c9tudes","ror":"https://ror.org/046b3cj80","country_code":"FR","type":"education","lineage":["https://openalex.org/I159885104","https://openalex.org/I2746051580"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Omar Bennani","raw_affiliation_strings":["Ecole Pratique des Hautes Etudes, Paris, France","Ecole Pratique des Hautes Etudes, 41 rue Gay Lussac, 75005, Paris, France"],"affiliations":[{"raw_affiliation_string":"Ecole Pratique des Hautes Etudes, Paris, France","institution_ids":["https://openalex.org/I159885104"]},{"raw_affiliation_string":"Ecole Pratique des Hautes Etudes, 41 rue Gay Lussac, 75005, Paris, France","institution_ids":["https://openalex.org/I159885104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008040266","display_name":"Pierre Chauvet","orcid":"https://orcid.org/0000-0002-3843-5179"},"institutions":[{"id":"https://openalex.org/I32956416","display_name":"Universit\u00e9 catholique de l'ouest","ror":"https://ror.org/00jzv1t04","country_code":"FR","type":"education","lineage":["https://openalex.org/I32956416"]},{"id":"https://openalex.org/I4210135273","display_name":"Laboratoire Interuniversitaire des Syst\u00e8mes Atmosph\u00e9riques","ror":"https://ror.org/046cjf283","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I197681013","https://openalex.org/I204730241","https://openalex.org/I4210135273","https://openalex.org/I4210148025"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I4210159180","display_name":"Laboratoire Techniques, Territoires et Soci\u00e9t\u00e9s","ror":"https://ror.org/05fc1hn07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I142631665","https://openalex.org/I4210145102","https://openalex.org/I4210150854","https://openalex.org/I4210154111","https://openalex.org/I4210159180"]}],"countries":["BE","FR"],"is_corresponding":false,"raw_author_name":"Pierre Chauvet","raw_affiliation_strings":["LISA EA4014, Universit\u00e9 Catholique de Louvain, Angers, France","LISA EA4014 - Universit\u00e9 Catholique de l'Ouest, 44 rue Rabelais, Angers, BP808 49008 France"],"affiliations":[{"raw_affiliation_string":"LISA EA4014, Universit\u00e9 Catholique de Louvain, Angers, France","institution_ids":["https://openalex.org/I32956416","https://openalex.org/I4210135273","https://openalex.org/I4210159180","https://openalex.org/I95674353"]},{"raw_affiliation_string":"LISA EA4014 - Universit\u00e9 Catholique de l'Ouest, 44 rue Rabelais, Angers, BP808 49008 France","institution_ids":["https://openalex.org/I32956416","https://openalex.org/I4210135273","https://openalex.org/I4210159180"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082161694","display_name":"Jean-marc Dupont","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Marc Dupont","raw_affiliation_strings":["VFS-Bio, Paris, France","VFS-Bio, 24 rue Saint Martin, 75004, Paris, France"],"affiliations":[{"raw_affiliation_string":"VFS-Bio, Paris, France","institution_ids":[]},{"raw_affiliation_string":"VFS-Bio, 24 rue Saint Martin, 75004, Paris, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014511314"],"corresponding_institution_ids":["https://openalex.org/I159885104"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.07729531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"1","issue":null,"first_page":"1406","last_page":"1416"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9178000092506409,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9178000092506409,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9125000238418579,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13106","display_name":"Neuroscience, Education and Cognitive Function","score":0.9085999727249146,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/formalism","display_name":"Formalism (music)","score":0.6634464263916016},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6494752764701843},{"id":"https://openalex.org/keywords/cognitive-science","display_name":"Cognitive science","score":0.6022061705589294},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.518846869468689},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.48247483372688293},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.32985830307006836},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2334635853767395},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.1551138162612915},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1274101734161377}],"concepts":[{"id":"https://openalex.org/C73301696","wikidata":"https://www.wikidata.org/wiki/Q5469984","display_name":"Formalism (music)","level":3,"score":0.6634464263916016},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6494752764701843},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.6022061705589294},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.518846869468689},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48247483372688293},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.32985830307006836},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2334635853767395},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1551138162612915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1274101734161377},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C558565934","wikidata":"https://www.wikidata.org/wiki/Q2743","display_name":"Musical","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bicta.2010.5645287","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bicta.2010.5645287","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE Fifth International Conference on Bio-Inspired Computing: Theories and Applications (BIC-TA)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6299999952316284}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1978809639","https://openalex.org/W2009544901","https://openalex.org/W2035254643","https://openalex.org/W2041506136","https://openalex.org/W2065962343","https://openalex.org/W2109558402","https://openalex.org/W2136599346","https://openalex.org/W2153911392","https://openalex.org/W4298327400","https://openalex.org/W4302081714","https://openalex.org/W6843592386"],"related_works":["https://openalex.org/W2480711475","https://openalex.org/W2952002389","https://openalex.org/W2231510842","https://openalex.org/W2061997414","https://openalex.org/W3106363734","https://openalex.org/W1587522533","https://openalex.org/W2153190755","https://openalex.org/W2121182182","https://openalex.org/W1969707919","https://openalex.org/W1996411829"],"abstract_inverted_index":{"The":[0],"modeling":[1],"and":[2,71,85],"the":[3,22,52,65,72,75,81,87],"simulation":[4],"of":[5,15,26,41,58,64,74],"biological":[6],"structure":[7],"needs":[8],"a":[9,16,42,55,59],"united":[10],"formalism":[11],"for":[12],"all":[13],"parts":[14],"living":[17,43,60],"system.":[18,44],"For":[19],"this":[20,46],"purpose":[21],"MTIP":[23],"(Mathematical":[24],"Theory":[25],"Integrative":[27],"Physiology)":[28],"has":[29],"been":[30],"developed,":[31],"by":[32],"Pr":[33],"Gilbert":[34],"Chauvet,":[35],"to":[36,67,83],"offer":[37],"an":[38],"integrated":[39],"description":[40],"In":[45],"paper":[47],"we":[48],"will":[49],"present":[50],"mainly":[51],"passage":[53],"from":[54],"mathematical":[56],"view":[57],"subsystem":[61],"(CA1":[62],"circuit":[63],"hippocampus)":[66],"its":[68],"computational":[69],"implementation":[70],"development":[73],"simulator":[76],"that":[77],"goes":[78],"with":[79],"in":[80],"aim":[82],"use":[84],"validate":[86],"MTIP.":[88]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}