{"id":"https://openalex.org/W2026958495","doi":"https://doi.org/10.1109/bibmw.2012.6470296","title":"A biclustering approach to analyze drug effects on extracellular matrix remodeling post-myocardial infarction","display_name":"A biclustering approach to analyze drug effects on extracellular matrix remodeling post-myocardial infarction","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2026958495","doi":"https://doi.org/10.1109/bibmw.2012.6470296","mag":"2026958495"},"language":"en","primary_location":{"id":"doi:10.1109/bibmw.2012.6470296","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2012.6470296","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013629335","display_name":"Omid Ghasemi","orcid":"https://orcid.org/0000-0002-0726-8566"},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Omid Ghasemi","raw_affiliation_strings":["Dept. of Electrical & Computer Engineering, UTSA, San Antonio, TX, USA","Department of Electrical and Computer Engineering, UTSA, San Antonio, TX, USA"],"affiliations":[{"raw_affiliation_string":"Dept. of Electrical & Computer Engineering, UTSA, San Antonio, TX, USA","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, UTSA, San Antonio, TX, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904836","display_name":"Nguyen Nguyen","orcid":null},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nguyen Nguyen","raw_affiliation_strings":["Dept. of Electrical & Computer Engineering, UTSA, San Antonio, TX, USA","Department of Electrical and Computer Engineering, UTSA, San Antonio, TX, USA"],"affiliations":[{"raw_affiliation_string":"Dept. of Electrical & Computer Engineering, UTSA, San Antonio, TX, USA","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, UTSA, San Antonio, TX, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036169339","display_name":"Trevi A. Ramirez","orcid":"https://orcid.org/0000-0003-3722-4879"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trevi A Ramirez","raw_affiliation_strings":["Barshop Institute for Longevity And Aging Studies UTHSCSA, San Antonio, TX, USA","Barshop Institute for Longevity and Aging Studies, UTHSCSA, San Antonio, TX, USA"],"affiliations":[{"raw_affiliation_string":"Barshop Institute for Longevity And Aging Studies UTHSCSA, San Antonio, TX, USA","institution_ids":[]},{"raw_affiliation_string":"Barshop Institute for Longevity and Aging Studies, UTHSCSA, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434755","display_name":"Jianhua Zhang","orcid":"https://orcid.org/0000-0001-5412-9860"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhua Zhang","raw_affiliation_strings":["Barshop Institute for Longevity And Aging Studies UTHSCSA, San Antonio, TX, USA","Barshop Institute for Longevity and Aging Studies, UTHSCSA, San Antonio, TX, USA"],"affiliations":[{"raw_affiliation_string":"Barshop Institute for Longevity And Aging Studies UTHSCSA, San Antonio, TX, USA","institution_ids":[]},{"raw_affiliation_string":"Barshop Institute for Longevity and Aging Studies, UTHSCSA, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058202537","display_name":"Merry L. Lindsey","orcid":"https://orcid.org/0000-0002-4090-0391"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Merry L Lindsey","raw_affiliation_strings":["Barshop Institute for Longevity And Aging Studies UTHSCSA, San Antonio, TX, USA","Barshop Institute for Longevity and Aging Studies, UTHSCSA, San Antonio, TX, USA"],"affiliations":[{"raw_affiliation_string":"Barshop Institute for Longevity And Aging Studies UTHSCSA, San Antonio, TX, USA","institution_ids":[]},{"raw_affiliation_string":"Barshop Institute for Longevity and Aging Studies, UTHSCSA, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046855484","display_name":"Yufang Jin","orcid":"https://orcid.org/0000-0002-9049-9807"},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Fang Jin","raw_affiliation_strings":["Dept. of Electrical & Computer Engineering, UTSA, San Antonio, TX, USA","Department of Electrical and Computer Engineering, UTSA, San Antonio, TX, USA"],"affiliations":[{"raw_affiliation_string":"Dept. of Electrical & Computer Engineering, UTSA, San Antonio, TX, USA","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, UTSA, San Antonio, TX, USA","institution_ids":["https://openalex.org/I45438204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5013629335"],"corresponding_institution_ids":["https://openalex.org/I45438204"],"apc_list":null,"apc_paid":null,"fwci":0.9316,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.77630108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":null,"first_page":"143","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"Extracellular matrix","score":0.7645608186721802},{"id":"https://openalex.org/keywords/tenascin-c","display_name":"Tenascin C","score":0.7556785345077515},{"id":"https://openalex.org/keywords/osteopontin","display_name":"Osteopontin","score":0.6825317740440369},{"id":"https://openalex.org/keywords/tenascin","display_name":"Tenascin","score":0.6146133542060852},{"id":"https://openalex.org/keywords/thrombospondin","display_name":"Thrombospondin","score":0.43937426805496216},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3667680323123932},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3564389944076538},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3444029688835144},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3408932685852051},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.30622202157974243},{"id":"https://openalex.org/keywords/matrix-metalloproteinase","display_name":"Matrix metalloproteinase","score":0.29978662729263306},{"id":"https://openalex.org/keywords/fibronectin","display_name":"Fibronectin","score":0.22285768389701843},{"id":"https://openalex.org/keywords/metalloproteinase","display_name":"Metalloproteinase","score":0.09592229127883911}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7645608186721802},{"id":"https://openalex.org/C117961784","wikidata":"https://www.wikidata.org/wiki/Q18027461","display_name":"Tenascin C","level":3,"score":0.7556785345077515},{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.6825317740440369},{"id":"https://openalex.org/C2777738151","wikidata":"https://www.wikidata.org/wiki/Q1903925","display_name":"Tenascin","level":4,"score":0.6146133542060852},{"id":"https://openalex.org/C167814343","wikidata":"https://www.wikidata.org/wiki/Q419341","display_name":"Thrombospondin","level":4,"score":0.43937426805496216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3667680323123932},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3564389944076538},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3444029688835144},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3408932685852051},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30622202157974243},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.29978662729263306},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.22285768389701843},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.09592229127883911}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibmw.2012.6470296","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2012.6470296","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1493217831","https://openalex.org/W1981294092","https://openalex.org/W1982815250","https://openalex.org/W1984502639","https://openalex.org/W1992918752","https://openalex.org/W2063550550","https://openalex.org/W2131230871","https://openalex.org/W2135000328","https://openalex.org/W2139234903","https://openalex.org/W2144544802","https://openalex.org/W2158217645","https://openalex.org/W2164963842","https://openalex.org/W2167993374","https://openalex.org/W2172165822","https://openalex.org/W4211146665","https://openalex.org/W6629329278"],"related_works":["https://openalex.org/W2566938983","https://openalex.org/W2747882396","https://openalex.org/W1964810899","https://openalex.org/W2021145609","https://openalex.org/W4242915321","https://openalex.org/W2084602170","https://openalex.org/W1988297300","https://openalex.org/W2143303285","https://openalex.org/W1267428002","https://openalex.org/W3100197996"],"abstract_inverted_index":{"Extracellular":[0],"matrix":[1,36,51,135,177],"(ECM)":[2],"remodeling":[3,37,229],"is":[4],"an":[5],"important":[6],"process":[7],"to":[8,29],"determine":[9,30],"the":[10,16,42,113,119,153,159,168,190,201,207,227],"functional":[11],"and":[12,67,76,122,129,147,181,197,215],"geometric":[13],"changes":[14],"of":[15,45,79,145],"left":[17],"ventricle":[18],"(LV)":[19],"post-myocardial":[20],"infarction":[21],"(MI).":[22],"Currently,":[23],"little":[24],"research":[25,238],"has":[26],"been":[27],"performed":[28],"key":[31],"factors":[32],"associated":[33],"with":[34,73,106,167],"extracellular":[35,50],"post-ML":[38],"We":[39,150,184],"have":[40,93],"collected":[41],"expression":[43],"levels":[44],"84":[46],"genes":[47,96,117,124,157,166],"in":[48,118,158,206,220],"LV":[49,228],"from":[52,84],"wild":[53],"type":[54],"C57BL/6J":[55],"mice":[56],"at":[57],"day":[58,62,68],"0":[59],"(control":[60],"group),":[61,66],"28":[63,69],"(MI":[64],"saline":[65],"MI":[70],"groups":[71],"treated":[72],"Aliskiren,":[74],"Valsartan,":[75],"a":[77,234],"combination":[78],"these":[80,95,123,241],"two":[81],"drugs,":[82],"given":[83],"3":[85],"h":[86],"post-MI":[87],"(number=6":[88],"each":[89],"group).":[90],"Further,":[91],"we":[92],"categorized":[94],"using":[97],"sparse":[98],"singular":[99],"value":[100],"decomposition":[101],"(SSVD)":[102],"based":[103],"biclustering":[104],"algorithm":[105],"measurement":[107],"noises":[108],"considered.":[109],"Our":[110,231],"results":[111,232],"identified":[112,152,191,205],"10":[114],"most":[115,155,202],"significant":[116,156,165,192,203],"infarct":[120,169,208],"region,":[121,161,222],"were":[125,200,218],"cadherin-1,":[126],"collagen":[127],"I":[128],"IL":[130,172],"connective":[131,173],"tissue":[132,174],"growth":[133,175],"factor,":[134,176],"metalloproteinase-3,":[136,178],"neural":[137],"cell":[138,195,211,213],"adhesion":[139,198],"molecule-2,":[140],"osteopontin,":[141,179],"thrombospondin-1,":[142,180],"Tissue":[143],"inhibitor":[144],"metallopreteinases-1,":[146],"tenascin":[148,182],"C.":[149],"also":[151],"15":[154],"non-infarct":[160,221],"which":[162],"shared":[163],"6":[164],"region":[170,209],"(collagen":[171],"C).":[183],"then":[185],"analyzed":[186],"pathways":[187,199,217],"enriched":[188,219],"by":[189],"genes.":[193],"Interestingly,":[194],"death":[196],"functions":[204],"while":[210],"adhesion,":[212],"migration,":[214],"inflammatory":[216],"suggesting":[223],"their":[224],"effect":[225],"on":[226],"process.":[230],"provide":[233],"rationale":[235],"for":[236],"future":[237],"that":[239],"target":[240],"pathways.":[242]},"counts_by_year":[{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}