{"id":"https://openalex.org/W2083564995","doi":"https://doi.org/10.1109/bibmw.2011.6112527","title":"Additive and multiplicative genome-wide association models identify genes associated with growth","display_name":"Additive and multiplicative genome-wide association models identify genes associated with growth","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2083564995","doi":"https://doi.org/10.1109/bibmw.2011.6112527","mag":"2083564995"},"language":"en","primary_location":{"id":"doi:10.1109/bibmw.2011.6112527","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2011.6112527","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109860393","display_name":"C Zavala","orcid":null},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C. Zavala","raw_affiliation_strings":["University of Illinois at Urbana-Champaign, Urbana, IL, US"],"affiliations":[{"raw_affiliation_string":"University of Illinois at Urbana-Champaign, Urbana, IL, US","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008909818","display_name":"Nick V. L. Ser\u00e3o","orcid":"https://orcid.org/0000-0002-6758-208X"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Serao","raw_affiliation_strings":["University of Illinois at Urbana-Champaign, Urbana, IL, US"],"affiliations":[{"raw_affiliation_string":"University of Illinois at Urbana-Champaign, Urbana, IL, US","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010527134","display_name":"Mar\u00eda B. Villamil","orcid":"https://orcid.org/0000-0003-3559-8981"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. B. Villamil","raw_affiliation_strings":["Department of Crop Sciences","Department of Crop Sciences, University of Illinois, Urbana-Champaign, Urbana, USA"],"affiliations":[{"raw_affiliation_string":"Department of Crop Sciences","institution_ids":[]},{"raw_affiliation_string":"Department of Crop Sciences, University of Illinois, Urbana-Champaign, Urbana, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026404241","display_name":"Gustavo Caetano\u2010Anoll\u00e9s","orcid":"https://orcid.org/0000-0001-5854-4121"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Caetano-Anolles","raw_affiliation_strings":["Department of Crop Sciences","Department of Crop Sciences, University of Illinois, Urbana-Champaign, Urbana, USA"],"affiliations":[{"raw_affiliation_string":"Department of Crop Sciences","institution_ids":[]},{"raw_affiliation_string":"Department of Crop Sciences, University of Illinois, Urbana-Champaign, Urbana, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058590776","display_name":"Sandra L. Rodriguez\u2010Zas","orcid":"https://orcid.org/0000-0003-1122-4758"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. L. Rodriguez-Zas","raw_affiliation_strings":["Department of Statistics","Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, USA"],"affiliations":[{"raw_affiliation_string":"Department of Statistics","institution_ids":[]},{"raw_affiliation_string":"Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, USA","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5109860393"],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11017828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":null,"first_page":"975","last_page":"977"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.826921284198761},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6280280351638794},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.6241389513015747},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6142308712005615},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6079962253570557},{"id":"https://openalex.org/keywords/haplotype","display_name":"Haplotype","score":0.5198824405670166},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5170286297798157},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.5054769515991211},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.49227800965309143},{"id":"https://openalex.org/keywords/population-stratification","display_name":"Population stratification","score":0.4669438600540161},{"id":"https://openalex.org/keywords/additive-model","display_name":"Additive model","score":0.4537400007247925},{"id":"https://openalex.org/keywords/multiplicative-function","display_name":"Multiplicative function","score":0.41388750076293945},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3447611331939697},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1701166331768036},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15813994407653809}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.826921284198761},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6280280351638794},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6241389513015747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6142308712005615},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6079962253570557},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.5198824405670166},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5170286297798157},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5054769515991211},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.49227800965309143},{"id":"https://openalex.org/C166976648","wikidata":"https://www.wikidata.org/wiki/Q7229824","display_name":"Population stratification","level":5,"score":0.4669438600540161},{"id":"https://openalex.org/C203223496","wikidata":"https://www.wikidata.org/wiki/Q4681344","display_name":"Additive model","level":2,"score":0.4537400007247925},{"id":"https://openalex.org/C42747912","wikidata":"https://www.wikidata.org/wiki/Q1048447","display_name":"Multiplicative function","level":2,"score":0.41388750076293945},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3447611331939697},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1701166331768036},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15813994407653809},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibmw.2011.6112527","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2011.6112527","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.5299999713897705}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1966880393","https://openalex.org/W1966893029","https://openalex.org/W2015551558","https://openalex.org/W2095358593","https://openalex.org/W2104738297","https://openalex.org/W2168997921"],"related_works":["https://openalex.org/W1519331308","https://openalex.org/W2913076862","https://openalex.org/W2092985543","https://openalex.org/W2120483845","https://openalex.org/W2773587892","https://openalex.org/W2888432148","https://openalex.org/W2991138675","https://openalex.org/W2132299336","https://openalex.org/W2041269594","https://openalex.org/W2019660746"],"abstract_inverted_index":{"Standard":[0],"genome-wide":[1],"association":[2,6],"studies":[3],"evaluate":[4],"the":[5,41,78,115,118,123],"between":[7],"single":[8],"nucleotide":[9],"polymorphisms":[10,91],"(SNPs":[11],"or":[12,29,65],"Genotype":[13],"G)":[14],"and":[15,76,84,92,101],"phenotype":[16],"(e.g.":[17,63],"growth)":[18],"conditional":[19],"on":[20,32,60],"non-SNP":[21],"covariates":[22],"including":[23],"environmental":[24],"factors":[25],"(E,":[26],"e.g.":[27],"diet)":[28],"population":[30],"stratification,":[31],"an":[33],"additive":[34,124],"fashion.":[35,67],"For":[36],"traits":[37],"known":[38],"to":[39,74,89,105],"be":[40],"result":[42],"of":[43,70,80,117],"genotype-by-environment":[44],"interactions":[45],"(G\u00d7E),":[46],"like":[47],"growth,":[48],"a":[49,61,108],"multiplicative":[50],"model":[51],"could":[52],"potentially":[53],"uncover":[54],"additional":[55],"SNPs":[56],"that":[57,98,112],"influence":[58],"growth":[59,97],"context-dependent":[62,85],"diet":[64],"breed)":[66],"The":[68],"objective":[69],"this":[71],"study":[72],"was":[73,120],"assess":[75],"compare":[77],"performance":[79],"context-independent":[81,100],"(additive,":[82],"G+E)":[83],"(multiplicative,":[86],"G+E+G\u00d7E)":[87],"models":[88],"identify":[90],"corresponding":[93],"genes":[94],"associated":[95],"with":[96],"are":[99],"context-dependent.":[102],"In":[103],"addition":[104],"single-SNP":[106],"analysis,":[107],"multi-SNP":[109],"haplotype-based":[110],"analysis":[111],"can":[113],"increase":[114],"precision":[116],"estimates":[119],"evaluated":[121],"for":[122],"model.":[125]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}