{"id":"https://openalex.org/W2029480931","doi":"https://doi.org/10.1109/bibmw.2011.6112377","title":"Finding a longest open reading frame of an alternatively spliced gene","display_name":"Finding a longest open reading frame of an alternatively spliced gene","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2029480931","doi":"https://doi.org/10.1109/bibmw.2011.6112377","mag":"2029480931"},"language":"en","primary_location":{"id":"doi:10.1109/bibmw.2011.6112377","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2011.6112377","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062751459","display_name":"Neil Moore","orcid":"https://orcid.org/0000-0003-4945-8074"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"N. Moore","raw_affiliation_strings":["Department of Computer Science, University of Kentucky, Lexington, KY, USA","Dept. of Comput. Sci., Univ. of Kentucky, Lexington, KY, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Kentucky, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Dept. of Comput. Sci., Univ. of Kentucky, Lexington, KY, USA#TAB#","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058294332","display_name":"Jerzy W. Jaromczyk","orcid":"https://orcid.org/0000-0003-1427-4072"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. W. Jaromczyk","raw_affiliation_strings":["Department of Computer Science, University of Kentucky, Lexington, KY, USA","Dept. of Comput. Sci., Univ. of Kentucky, Lexington, KY, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Kentucky, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Dept. of Comput. Sci., Univ. of Kentucky, Lexington, KY, USA#TAB#","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062751459"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":0.2606,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57202825,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"215","last_page":"222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orfs","display_name":"ORFS","score":0.8325678110122681},{"id":"https://openalex.org/keywords/open-reading-frame","display_name":"Open reading frame","score":0.806989312171936},{"id":"https://openalex.org/keywords/frame","display_name":"Frame (networking)","score":0.5920482873916626},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5345885753631592},{"id":"https://openalex.org/keywords/reading","display_name":"Reading (process)","score":0.5076943635940552},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5076593160629272},{"id":"https://openalex.org/keywords/pruning","display_name":"Pruning","score":0.4848964810371399},{"id":"https://openalex.org/keywords/reading-frame","display_name":"Reading frame","score":0.4293244481086731},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.38373783230781555},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.36978214979171753},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3646761476993561},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2809145152568817},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.09816926717758179}],"concepts":[{"id":"https://openalex.org/C2780530800","wikidata":"https://www.wikidata.org/wiki/Q7072921","display_name":"ORFS","level":5,"score":0.8325678110122681},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.806989312171936},{"id":"https://openalex.org/C126042441","wikidata":"https://www.wikidata.org/wiki/Q1324888","display_name":"Frame (networking)","level":2,"score":0.5920482873916626},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5345885753631592},{"id":"https://openalex.org/C554936623","wikidata":"https://www.wikidata.org/wiki/Q199657","display_name":"Reading (process)","level":2,"score":0.5076943635940552},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5076593160629272},{"id":"https://openalex.org/C108010975","wikidata":"https://www.wikidata.org/wiki/Q500094","display_name":"Pruning","level":2,"score":0.4848964810371399},{"id":"https://openalex.org/C166253671","wikidata":"https://www.wikidata.org/wiki/Q923372","display_name":"Reading frame","level":5,"score":0.4293244481086731},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.38373783230781555},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36978214979171753},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3646761476993561},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2809145152568817},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.09816926717758179},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibmw.2011.6112377","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2011.6112377","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8700000047683716,"display_name":"Quality Education","id":"https://metadata.un.org/sdg/4"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W297888808","https://openalex.org/W1490430289","https://openalex.org/W1575350606","https://openalex.org/W1993158258","https://openalex.org/W2007006108","https://openalex.org/W2009329319","https://openalex.org/W2052503008","https://openalex.org/W2113322429","https://openalex.org/W2117465894","https://openalex.org/W2137096454"],"related_works":["https://openalex.org/W2017477982","https://openalex.org/W1978801575","https://openalex.org/W4306784270","https://openalex.org/W2087892992","https://openalex.org/W2029252138","https://openalex.org/W2114366735","https://openalex.org/W2120600301","https://openalex.org/W2056949357","https://openalex.org/W2082826073","https://openalex.org/W4386384143"],"abstract_inverted_index":{"This":[0,74],"paper":[1],"provides":[2],"a":[3,8,19,28,110],"deterministic":[4],"algorithm":[5],"for":[6,86],"finding":[7],"longest":[9,111],"open":[10,112],"reading":[11,113],"frame":[12,114],"(ORF)":[13],"among":[14,117],"all":[15],"alternative":[16],"splicings":[17],"of":[18,43,49,57,82,100],"given":[20],"DNA":[21,33],"sequence.":[22],"Finding":[23],"protein":[24],"encoding":[25],"regions":[26],"is":[27,52,76],"fundamental":[29],"problem":[30],"in":[31,54,65],"genomic":[32],"sequence":[34],"analysis":[35],"and":[36],"long":[37],"ORFs":[38],"generally":[39],"provide":[40],"good":[41],"predictions":[42],"such":[44],"regions.":[45],"Although":[46],"the":[47,55,80,83,92,98,118],"number":[48,56,99],"splice":[50],"variants":[51],"exponential":[53],"optionally":[58],"spliced":[59],"regions,":[60],"we":[61,95],"are":[62],"able":[63],"to":[64],"many":[66],"cases":[67],"obtain":[68],"quadratic":[69],"or":[70],"even":[71],"linear":[72],"performance.":[73],"efficiency":[75],"achieved":[77],"by":[78,89],"limiting":[79],"size":[81],"search":[84,93],"space":[85,94],"potential":[87],"ORFs:":[88],"properly":[90],"pruning":[91],"can":[96],"reduce":[97],"frames":[101],"considered":[102,119],"at":[103],"any":[104],"one":[105],"time":[106],"while":[107],"guaranteeing":[108],"that":[109],"must":[115],"be":[116],"frames.":[120]},"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}