{"id":"https://openalex.org/W2027220940","doi":"https://doi.org/10.1109/bibmw.2011.6112369","title":"Meta-analysis of LC-MS based metabolomic experiments","display_name":"Meta-analysis of LC-MS based metabolomic experiments","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2027220940","doi":"https://doi.org/10.1109/bibmw.2011.6112369","mag":"2027220940"},"language":"en","primary_location":{"id":"doi:10.1109/bibmw.2011.6112369","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2011.6112369","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027269811","display_name":"Rency S. Varghese","orcid":"https://orcid.org/0000-0002-4236-7316"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. S. Varghese","raw_affiliation_strings":["Department of Oncology, George town University, DC, USA"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, George town University, DC, USA","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083108695","display_name":"Bin Zhou","orcid":"https://orcid.org/0000-0003-3642-2048"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Zhou","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Falls Church, VA, USA","Department of Oncology, George town University, DC, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Falls Church, VA, USA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Oncology, George town University, DC, USA","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025125310","display_name":"Habtom W. Ressom","orcid":"https://orcid.org/0000-0001-9296-2132"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Ressom","raw_affiliation_strings":["Department of Oncology, George town University, DC, USA"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, George town University, DC, USA","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027269811"],"corresponding_institution_ids":["https://openalex.org/I184565670"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08351174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":null,"first_page":"157","last_page":"164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12073","display_name":"Isotope Analysis in Ecology","score":0.9869999885559082,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoisotopic-mass","display_name":"Monoisotopic mass","score":0.9599076509475708},{"id":"https://openalex.org/keywords/ion","display_name":"Ion","score":0.6819576025009155},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.6439909934997559},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.587242603302002},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4630783498287201},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4008341133594513},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.27362799644470215}],"concepts":[{"id":"https://openalex.org/C83387232","wikidata":"https://www.wikidata.org/wiki/Q3297559","display_name":"Monoisotopic mass","level":3,"score":0.9599076509475708},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.6819576025009155},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6439909934997559},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.587242603302002},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4630783498287201},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4008341133594513},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.27362799644470215},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibmw.2011.6112369","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2011.6112369","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1519955500","https://openalex.org/W1607252236","https://openalex.org/W1964010911","https://openalex.org/W1972978214","https://openalex.org/W1982185581","https://openalex.org/W1984703950","https://openalex.org/W1989299822","https://openalex.org/W2001265990","https://openalex.org/W2009453329","https://openalex.org/W2014186056","https://openalex.org/W2028240481","https://openalex.org/W2053385401","https://openalex.org/W2061445382","https://openalex.org/W2075109094","https://openalex.org/W2084375915","https://openalex.org/W2150827955","https://openalex.org/W2156613862","https://openalex.org/W2166360158","https://openalex.org/W2166671678","https://openalex.org/W4252684946"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2010548624","https://openalex.org/W3033241459","https://openalex.org/W1973619483","https://openalex.org/W2002098060"],"abstract_inverted_index":{"Meta-analysis":[0],"of":[1,27,41,61,72,76,136,152],"LC-MS":[2],"data":[3],"in":[4,19,64,104,143],"metabolomic":[5],"studies":[6,24],"is":[7,69,107,115],"desired":[8],"to":[9,33,45,56,118,139],"determine":[10,57],"overlaps":[11],"and":[12,83,132],"differences":[13],"among":[14],"various":[15],"experiments.":[16,124],"For":[17],"example,":[18],"large":[20,74],"metabolic":[21],"biomarker":[22],"discovery":[23],"involving":[25,38],"hundreds":[26],"samples,":[28],"it":[29],"may":[30],"be":[31],"necessary":[32],"conduct":[34],"multiple":[35,123],"experiments,":[36],"each":[37,52,102],"a":[39,73,105],"subset":[40],"the":[42,62,66,70,120,140,150],"samples":[43],"due":[44],"technical":[46],"limitations.":[47],"The":[48,125],"ions":[49,78,94,121,146],"selected":[50,148],"from":[51],"experiment":[53],"are":[54,147],"analyzed":[55],"overlapping":[58,145],"ions.":[59],"One":[60],"challenges":[63],"comparing":[65],"ion":[67,103,127,153],"lists":[68],"presence":[71],"number":[75],"derivative":[77],"such":[79],"as":[80],"isotopes,":[81],"adducts,":[82],"fragments.":[84],"In":[85],"this":[86,90],"paper,":[87],"we":[88],"address":[89],"issue":[91],"by":[92,109],"grouping":[93],"based":[95],"on":[96,149],"their":[97],"annotation":[98],"information.":[99],"Following":[100],"annotation,":[101],"cluster":[106],"represented":[108],"its":[110],"monoisotopic":[111],"mass.":[112,154],"This":[113],"mass":[114],"then":[116],"used":[117],"compare":[119],"across":[122],"resulting":[126],"list":[128],"provides":[129],"better":[130],"coverage":[131],"more":[133],"accurate":[134],"identification":[135],"metabolites":[137],"compared":[138],"traditional":[141],"approach":[142],"which":[144],"basis":[151]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}