{"id":"https://openalex.org/W2153383357","doi":"https://doi.org/10.1109/bibmw.2010.5703944","title":"Effects of cyclic stretch on early response gene expressions in normal human pulmonary artery endothelial cells in vitro","display_name":"Effects of cyclic stretch on early response gene expressions in normal human pulmonary artery endothelial cells in vitro","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2153383357","doi":"https://doi.org/10.1109/bibmw.2010.5703944","mag":"2153383357"},"language":"en","primary_location":{"id":"doi:10.1109/bibmw.2010.5703944","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2010.5703944","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112306601","display_name":"Kozue Kobayashi","orcid":null},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kozue Kobayashi","raw_affiliation_strings":["Graduate School of Medical Science, Kitasato University, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medical Science, Kitasato University, Kanagawa, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103386661","display_name":"Masumi Tanaka","orcid":null},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masumi Tanaka","raw_affiliation_strings":["School of Medicine, Kitasato University, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Kitasato University, Kanagawa, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074519766","display_name":"Hidenori Inaoka","orcid":"https://orcid.org/0000-0002-1752-1510"},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidenori Inaoka","raw_affiliation_strings":["Kitasato Daigaku, Minato-ku, Tokyo, JP"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kitasato Daigaku, Minato-ku, Tokyo, JP","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066461794","display_name":"Satoru Nebuya","orcid":null},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Nebuya","raw_affiliation_strings":["Kitasato Daigaku, Minato-ku, Tokyo, JP"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kitasato Daigaku, Minato-ku, Tokyo, JP","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046581863","display_name":"Kenichi Kokubo","orcid":"https://orcid.org/0000-0003-0922-7933"},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Kokubo","raw_affiliation_strings":["Kitasato Daigaku, Minato-ku, Tokyo, JP"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kitasato Daigaku, Minato-ku, Tokyo, JP","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009372894","display_name":"Yutaka Fukuoka","orcid":"https://orcid.org/0000-0001-6261-3783"},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yutaka Fukuoka","raw_affiliation_strings":["Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056002586","display_name":"Hirosuke Kobayashi","orcid":null},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirosuke Kobayashi","raw_affiliation_strings":["Kitasato Daigaku, Minato-ku, Tokyo, JP"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kitasato Daigaku, Minato-ku, Tokyo, JP","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040349953","display_name":"Makoto Noshiro","orcid":null},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Noshiro","raw_affiliation_strings":["Kitasato Daigaku, Minato-ku, Tokyo, JP"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kitasato Daigaku, Minato-ku, Tokyo, JP","institution_ids":["https://openalex.org/I64189623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20633066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"857","last_page":"858"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-artery","display_name":"Pulmonary artery","score":0.6218546628952026},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.6128519773483276},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4922403395175934},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4771651327610016},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3841973543167114},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3578539192676544},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3403312563896179},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3059825897216797},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2910192310810089},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11624255776405334}],"concepts":[{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.6218546628952026},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6128519773483276},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4922403395175934},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4771651327610016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3841973543167114},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3578539192676544},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3403312563896179},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3059825897216797},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2910192310810089},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11624255776405334}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibmw.2010.5703944","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2010.5703944","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5799999833106995,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2008848433","https://openalex.org/W2062082715","https://openalex.org/W2072610511","https://openalex.org/W2085417504","https://openalex.org/W2099764303","https://openalex.org/W2106016783","https://openalex.org/W2106645827","https://openalex.org/W2122641338","https://openalex.org/W2167878004"],"related_works":["https://openalex.org/W2131250617","https://openalex.org/W368915390","https://openalex.org/W2374957044","https://openalex.org/W2408898686","https://openalex.org/W4233034052","https://openalex.org/W2371030422","https://openalex.org/W2334770922","https://openalex.org/W2389442601","https://openalex.org/W2357975565","https://openalex.org/W2024578473"],"abstract_inverted_index":{"The":[0,31,58],"effects":[1],"of":[2,11,60],"cyclic":[3],"stretch":[4,29],"(within":[5],"30":[6],"min)":[7],"on":[8],"the":[9,50],"expressions":[10],"early":[12,33,37,67],"response":[13,34,39],"genes":[14,35,59],"in":[15,27],"normal":[16],"human":[17],"pulmonary":[18],"artery":[19],"endothelial":[20],"cells":[21],"(HPAEC)":[22],"were":[23,36,64],"investigated":[24,32],"using":[25],"an":[26],"vitro":[28],"system.":[30],"growth":[38],"gene":[40],"1":[41],"(Egr1),":[42],"heat-shock":[43],"protein":[44],"4":[45],"(Hspa4),":[46],"PTGS4":[47],"(cox2)":[48],"and":[49,56,62],"inflammatory":[51],"cytokines":[52],"interleukin":[53],"(IL)-1,":[54],"IL-6":[55],"IL-8.":[57],"Egr1":[61],"PTGS2":[63],"upregulated":[65],"at":[66],"stages":[68],"by":[69],"cycle":[70],"stretch.":[71]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}