{"id":"https://openalex.org/W2126282972","doi":"https://doi.org/10.1109/bibmw.2010.5703856","title":"A novel peak alignment method for LC-MS data analysis using cluster-based techniques","display_name":"A novel peak alignment method for LC-MS data analysis using cluster-based techniques","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2126282972","doi":"https://doi.org/10.1109/bibmw.2010.5703856","mag":"2126282972"},"language":"en","primary_location":{"id":"doi:10.1109/bibmw.2010.5703856","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2010.5703856","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103478576","display_name":"Yucheng Liu","orcid":"https://orcid.org/0009-0003-7825-3411"},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yu-Cheng Liu","raw_affiliation_strings":["Department of Computer Science and Information Engineering, National Cheng Kung University, Taiwan","[Department of Computer Science and Information Engineering, National Cheng Kung University, Taiwan, R.O.C]"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Engineering, National Cheng Kung University, Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"[Department of Computer Science and Information Engineering, National Cheng Kung University, Taiwan, R.O.C]","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110247339","display_name":"Lien-Chin Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210098366","display_name":"Institute of Information Science, Academia Sinica","ror":"https://ror.org/00z83z196","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210098366","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Lien-Chin Chen","raw_affiliation_strings":["Institute of Information Science, Academia Sinica, Taiwan","Institute of Information Science, Academia Sinica, Taiwan, R.O.C"],"affiliations":[{"raw_affiliation_string":"Institute of Information Science, Academia Sinica, Taiwan","institution_ids":["https://openalex.org/I4210098366"]},{"raw_affiliation_string":"Institute of Information Science, Academia Sinica, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4210098366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013744415","display_name":"Hui-Yin Chang","orcid":"https://orcid.org/0000-0003-1767-1874"},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hui-Yin Chang","raw_affiliation_strings":["Institute of Medical Informatics, National Cheng Kung University, Taiwan","Institute of Medical Informatics, National Cheng Kung University, Taiwan, R.O.C"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Informatics, National Cheng Kung University, Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"Institute of Medical Informatics, National Cheng Kung University, Taiwan, R.O.C","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066133791","display_name":"Hsin\u2010Yi Wu","orcid":"https://orcid.org/0000-0003-0722-0201"},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Yi Wu","raw_affiliation_strings":["Department of Environmental and Occupational Health, National Cheng Kung University, Taiwan","Department of Environmental and Occupational Health, National Cheng Kung University, Taiwan, R.O.C"],"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health, National Cheng Kung University, Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"Department of Environmental and Occupational Health, National Cheng Kung University, Taiwan, R.O.C","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047171658","display_name":"Pao\u2010Chi Liao","orcid":"https://orcid.org/0000-0001-8510-9870"},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pao-Chi Liao","raw_affiliation_strings":["Department of Environmental and Occupational Health, National Cheng Kung University, Taiwan","Department of Environmental and Occupational Health, National Cheng Kung University, Taiwan, R.O.C"],"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health, National Cheng Kung University, Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"Department of Environmental and Occupational Health, National Cheng Kung University, Taiwan, R.O.C","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043399804","display_name":"Vincent S. Tseng","orcid":"https://orcid.org/0000-0002-4853-1594"},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Vincent S. Tseng","raw_affiliation_strings":["Institute of Medical Informatics, National Cheng Kung University, Taiwan","[Department of Computer Science and Information Engineering, National Cheng Kung University, Taiwan, R.O.C]"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Informatics, National Cheng Kung University, Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"[Department of Computer Science and Information Engineering, National Cheng Kung University, Taiwan, R.O.C]","institution_ids":["https://openalex.org/I91807558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5103478576"],"corresponding_institution_ids":["https://openalex.org/I91807558"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13048583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":null,"first_page":"525","last_page":"530"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9832000136375427,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6566187143325806},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6448408365249634},{"id":"https://openalex.org/keywords/preprocessor","display_name":"Preprocessor","score":0.6129902005195618},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.48440319299697876},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4784431755542755},{"id":"https://openalex.org/keywords/cluster","display_name":"Cluster (spacecraft)","score":0.4744488000869751},{"id":"https://openalex.org/keywords/data-pre-processing","display_name":"Data pre-processing","score":0.42292332649230957},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4208064675331116},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3420547842979431}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6566187143325806},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6448408365249634},{"id":"https://openalex.org/C34736171","wikidata":"https://www.wikidata.org/wiki/Q918333","display_name":"Preprocessor","level":2,"score":0.6129902005195618},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.48440319299697876},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4784431755542755},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.4744488000869751},{"id":"https://openalex.org/C10551718","wikidata":"https://www.wikidata.org/wiki/Q5227332","display_name":"Data pre-processing","level":2,"score":0.42292332649230957},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4208064675331116},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3420547842979431},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibmw.2010.5703856","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2010.5703856","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1729812787","https://openalex.org/W1908438417","https://openalex.org/W1968152658","https://openalex.org/W1979985441","https://openalex.org/W1991777486","https://openalex.org/W1995062121","https://openalex.org/W1999517677","https://openalex.org/W2011716229","https://openalex.org/W2024081693","https://openalex.org/W2093151505","https://openalex.org/W2105696555","https://openalex.org/W2114172236","https://openalex.org/W2118868857","https://openalex.org/W2129343699","https://openalex.org/W2138838392","https://openalex.org/W2144899297","https://openalex.org/W2146197170","https://openalex.org/W2150401591","https://openalex.org/W2159904142","https://openalex.org/W6653458013"],"related_works":["https://openalex.org/W2989490741","https://openalex.org/W1629127207","https://openalex.org/W3092506759","https://openalex.org/W2367545121","https://openalex.org/W4248881655","https://openalex.org/W2482165163","https://openalex.org/W3010890513","https://openalex.org/W120741642","https://openalex.org/W138569904","https://openalex.org/W2952736244"],"abstract_inverted_index":{"Recently,":[0],"liquid":[1],"chromatography":[2],"coupled":[3],"to":[4,33,49,112,128],"mass":[5],"spectrometry":[6],"(LC-MS)":[7],"has":[8],"become":[9],"a":[10,66,72,106,123],"standard":[11],"technique":[12,74,125],"for":[13,75],"identifying":[14],"differential":[15],"abundance":[16],"of":[17,27,93,157],"peaks":[18,79],"as":[19],"biomarkers.":[20],"Two":[21],"major":[22],"problems":[23],"in":[24,53],"the":[25,51,77,82,103,114,120,130,149,155,163],"preprocessing":[26],"LC-MS":[28,38,151],"data":[29],"analysis":[30],"are":[31],"how":[32],"adjust":[34,50,113],"and":[35,41,56,80,99,142],"align":[36,57,129],"multiple":[37],"datasets":[39],"efficiently":[40],"correctly.":[42],"Hence,":[43],"an":[44],"effective":[45],"algorithm":[46,91,141],"is":[47,110,126],"needed":[48],"variation":[52],"retention":[54],"time":[55],"protein":[58,84],"signals":[59,85],"automatically.":[60],"In":[61,102,119],"this":[62],"study,":[63],"we":[64,153],"proposed":[65,159],"novel":[67],"algorithm,":[68,144,160],"PeakAlign,":[69,161],"based":[70],"on":[71,162],"clustering":[73],"adjusting":[76],"shifted":[78],"aligning":[81],"same":[83],"from":[86],"different":[87,137],"samples.":[88,165],"The":[89],"PeakAlign":[90],"consists":[92],"two":[94,136],"phases,":[95],"namely":[96],"adjustment":[97,104],"phase":[98],"alignment":[100,121,138],"phase.":[101],"phase,":[105,122],"LOESS":[107],"regression":[108],"method":[109],"used":[111],"shifting":[115],"trend":[116],"among":[117],"peaks.":[118,132],"cluster-based":[124],"applied":[127],"adjusted":[131],"For":[133],"experimental":[134],"evaluation,":[135],"approaches,":[139],"SlidingWin":[140],"DTW":[143],"were":[145],"implemented.":[146],"Through":[147],"analyzing":[148],"real":[150],"dataset,":[152],"demonstrate":[154],"usefulness":[156],"our":[158],"LC-MS-based":[164]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}