{"id":"https://openalex.org/W2167910449","doi":"https://doi.org/10.1109/bibmw.2010.5703827","title":"Two-way interaction analysis of obesity trait from Korean population using generalized MDR","display_name":"Two-way interaction analysis of obesity trait from Korean population using generalized MDR","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2167910449","doi":"https://doi.org/10.1109/bibmw.2010.5703827","mag":"2167910449"},"language":"en","primary_location":{"id":"doi:10.1109/bibmw.2010.5703827","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2010.5703827","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076575654","display_name":"Sungyoung Lee","orcid":"https://orcid.org/0000-0003-3458-1440"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I28777354","display_name":"Sejong University","ror":"https://ror.org/00aft1q37","country_code":"KR","type":"education","lineage":["https://openalex.org/I28777354"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sungyoung Lee","raw_affiliation_strings":["Department of Applied Mathematics, Sejong University, Seoul, South Korea","Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics, Sejong University, Seoul, South Korea","institution_ids":["https://openalex.org/I28777354"]},{"raw_affiliation_string":"Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042149642","display_name":"Sohee Oh","orcid":"https://orcid.org/0000-0002-3010-448X"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sohee Oh","raw_affiliation_strings":["Department of Statistics, Seoul National University, Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025860059","display_name":"Minseok Kwon","orcid":"https://orcid.org/0000-0001-6938-8048"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min-Seok Kwon","raw_affiliation_strings":["Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034909134","display_name":"Seungyeoun Lee","orcid":"https://orcid.org/0000-0001-7941-8933"},"institutions":[{"id":"https://openalex.org/I28777354","display_name":"Sejong University","ror":"https://ror.org/00aft1q37","country_code":"KR","type":"education","lineage":["https://openalex.org/I28777354"]},{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seungyeoun Lee","raw_affiliation_strings":["Department of Applied Mathematics, Sejong University, Seoul, South Korea","Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics, Sejong University, Seoul, South Korea","institution_ids":["https://openalex.org/I28777354"]},{"raw_affiliation_string":"Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100643662","display_name":"Taesung Park","orcid":"https://orcid.org/0000-0002-8294-590X"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Taesung Park","raw_affiliation_strings":["Department of Statistics, Seoul National University, Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5076575654"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I28777354"],"apc_list":null,"apc_paid":null,"fwci":0.3703,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.6964734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"353","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.8591257333755493},{"id":"https://openalex.org/keywords/multifactor-dimensionality-reduction","display_name":"Multifactor dimensionality reduction","score":0.8033406138420105},{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.6903901100158691},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5374864339828491},{"id":"https://openalex.org/keywords/genotyping","display_name":"Genotyping","score":0.5279898643493652},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5172784328460693},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.5012524127960205},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4605727195739746},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.43648597598075867},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3874503970146179},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32685133814811707},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.28588977456092834},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.27110975980758667},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.22360166907310486},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1508491039276123}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.8591257333755493},{"id":"https://openalex.org/C25249476","wikidata":"https://www.wikidata.org/wiki/Q6934678","display_name":"Multifactor dimensionality reduction","level":5,"score":0.8033406138420105},{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.6903901100158691},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5374864339828491},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.5279898643493652},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5172784328460693},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5012524127960205},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4605727195739746},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43648597598075867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3874503970146179},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32685133814811707},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28588977456092834},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27110975980758667},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.22360166907310486},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1508491039276123},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibmw.2010.5703827","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2010.5703827","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1974739080","https://openalex.org/W1978926020","https://openalex.org/W1979671436","https://openalex.org/W1981121263","https://openalex.org/W1983769109","https://openalex.org/W1988089886","https://openalex.org/W1993507262","https://openalex.org/W1998957301","https://openalex.org/W2029184743","https://openalex.org/W2032480348","https://openalex.org/W2059208857","https://openalex.org/W2063398309","https://openalex.org/W2066669827","https://openalex.org/W2066874799","https://openalex.org/W2072685350","https://openalex.org/W2084150578","https://openalex.org/W2088847440","https://openalex.org/W2092082564","https://openalex.org/W2097660065","https://openalex.org/W2110604469","https://openalex.org/W2110678911","https://openalex.org/W2120181458","https://openalex.org/W2121126323","https://openalex.org/W2129254992","https://openalex.org/W2140609764","https://openalex.org/W2141642891","https://openalex.org/W2154572047","https://openalex.org/W2612235007","https://openalex.org/W6658637596"],"related_works":["https://openalex.org/W2140249224","https://openalex.org/W1998101959","https://openalex.org/W1993755972","https://openalex.org/W2594299395","https://openalex.org/W2066467839","https://openalex.org/W2111842731","https://openalex.org/W2170506381","https://openalex.org/W2765794416","https://openalex.org/W2039666944","https://openalex.org/W1531630856"],"abstract_inverted_index":{"Most":[0],"common":[1],"complex":[2,47],"traits":[3],"such":[4,131],"as":[5,132],"obesity,":[6],"hypertension,":[7],"diabetes,":[8],"and":[9,21,214],"cancers":[10],"are":[11],"known":[12,219],"to":[13,32,88,103,107,117,187,220],"be":[14,221],"associated":[15,204,222],"with":[16,134,194,205,223],"multiple":[17,44],"genes,":[18],"environmental":[19],"factors,":[20],"epistasis.":[22],"Recently,":[23],"the":[24,34,41,69,144,158,162,179],"development":[25],"of":[26,43,68,91,128,201],"advanced":[27],"genotyping":[28],"technologies":[29],"allows":[30],"us":[31],"perform":[33,118,139],"genome-wide":[35],"association":[36],"studies":[37],"(GWAS).":[38],"For":[39],"detecting":[40,73,198],"effects":[42],"genes":[45,213],"on":[46],"traits,":[48],"many":[49],"approaches":[50],"have":[51,217],"been":[52,218],"proposed":[53,60],"for":[54,72,121,143,157,161,178,197],"GWAS.":[55],"Multifactor":[56],"dimensionality":[57],"reduction":[58],"(MDR)":[59],"by":[61],"Ritchie":[62],"et":[63],"al.":[64],"(2001)":[65],"is":[66,84,99,169],"one":[67],"powerful":[70],"methods":[71],"epistasis,":[74],"which":[75,216],"detects":[76],"high":[77],"order":[78],"interactions":[79,200],"among":[80],"genes.":[81],"However,":[82],"MDR":[83,105,119,140,150,159],"computationally":[85],"intensive":[86],"due":[87],"its":[89],"requirement":[90],"testing":[92],"all":[93],"possible":[94],"n-way":[95],"combinations.":[96],"Thus,":[97],"it":[98],"not":[100],"practically":[101],"feasible":[102],"apply":[104],"directly":[106],"analyzing":[108],"large-scale":[109,180],"GWAS":[110,122,181],"data.":[111,123,182],"We":[112,171,183,210],"propose":[113],"an":[114],"efficient":[115],"strategy":[116,186],"analysis":[120,141,160],"First,":[124],"select":[125],"a":[126,165],"subset":[127],"genetic":[129,146,202],"factors":[130,203],"SNPs":[133],"some":[135],"marginal":[136],"significance.":[137],"Second,":[138],"only":[142],"selected":[145,163],"factors.":[147],"Third,":[148],"provide":[149],"summary":[151],"results":[152],"through":[153],"network":[154],"graph.":[155],"Even":[156],"SNPs,":[164],"fast":[166],"computing":[167],"system":[168,177],"required.":[170],"developed":[172],"our":[173,185],"own":[174],"GPU":[175],"based":[176],"applied":[184],"Korean":[188],"Association":[189],"REsource":[190],"(KARE)":[191],"(8,838":[192],"individuals":[193],"101,837":[195],"SNPs)":[196],"two-way":[199],"body":[206],"mass":[207],"index":[208],"(BMI).":[209],"identified":[211],"several":[212],"pathways":[215],"obesity.":[224]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
