{"id":"https://openalex.org/W7126094791","doi":"https://doi.org/10.1109/bibm66473.2025.11357237","title":"Re-Thinking the Nature of Planning for Safe and Personalized Treatment Management Planning Using Large Language Models","display_name":"Re-Thinking the Nature of Planning for Safe and Personalized Treatment Management Planning Using Large Language Models","publication_year":2025,"publication_date":"2025-12-15","ids":{"openalex":"https://openalex.org/W7126094791","doi":"https://doi.org/10.1109/bibm66473.2025.11357237"},"language":null,"primary_location":{"id":"doi:10.1109/bibm66473.2025.11357237","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11357237","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041605932","display_name":"Muhammad Tariq Ayoub","orcid":"https://orcid.org/0009-0007-2464-1207"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Muhammad Ayoub","raw_affiliation_strings":["AGI Institute, School of Computer Science Shanghai Jiaotong University,Shanghai,China"],"affiliations":[{"raw_affiliation_string":"AGI Institute, School of Computer Science Shanghai Jiaotong University,Shanghai,China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124158954","display_name":"Hai Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai Zhao","raw_affiliation_strings":["AGI Institute, School of Computer Science Shanghai Jiaotong University,Shanghai,China"],"affiliations":[{"raw_affiliation_string":"AGI Institute, School of Computer Science Shanghai Jiaotong University,Shanghai,China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124276118","display_name":"Dongjie Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongjie Yang","raw_affiliation_strings":["AGI Institute, School of Computer Science Shanghai Jiaotong University,Shanghai,China"],"affiliations":[{"raw_affiliation_string":"AGI Institute, School of Computer Science Shanghai Jiaotong University,Shanghai,China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049086157","display_name":"Hongming Shan","orcid":"https://orcid.org/0000-0002-0604-3197"},"institutions":[{"id":"https://openalex.org/I4210164150","display_name":"Shanghai Center for Brain Science and Brain-Inspired Technology","ror":"https://ror.org/0551a0y31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210164150"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongming Shan","raw_affiliation_strings":["Institute of Science and Technology for Brain-inspired Intelligence Fudan University,Shanghai,China"],"affiliations":[{"raw_affiliation_string":"Institute of Science and Technology for Brain-inspired Intelligence Fudan University,Shanghai,China","institution_ids":["https://openalex.org/I4210164150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039924074","display_name":"Yi Yang","orcid":"https://orcid.org/0000-0002-8917-2196"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifei Yang","raw_affiliation_strings":["AGI Institute, School of Computer Science Shanghai Jiaotong University,Shanghai,China"],"affiliations":[{"raw_affiliation_string":"AGI Institute, School of Computer Science Shanghai Jiaotong University,Shanghai,China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100637036","display_name":"Lifeng Li","orcid":"https://orcid.org/0000-0002-8405-6639"},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lifeng Li","raw_affiliation_strings":["The First Affiliated Hospital of Nanchang University,Department of Radiology,Nanchang,China"],"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Nanchang University,Department of Radiology,Nanchang,China","institution_ids":["https://openalex.org/I4210164024","https://openalex.org/I141649914"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5041605932"],"corresponding_institution_ids":["https://openalex.org/I183067930"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.87406372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2012","last_page":"2017"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.8855000138282776,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.8855000138282776,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10028","display_name":"Topic Modeling","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.6269999742507935},{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.517300009727478},{"id":"https://openalex.org/keywords/radiation-treatment-planning","display_name":"Radiation treatment planning","score":0.504800021648407},{"id":"https://openalex.org/keywords/narrative","display_name":"Narrative","score":0.3447999954223633},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.3440999984741211},{"id":"https://openalex.org/keywords/state","display_name":"State (computer science)","score":0.3345000147819519},{"id":"https://openalex.org/keywords/baseline","display_name":"Baseline (sea)","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.6269999742507935},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5825999975204468},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.517300009727478},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.504800021648407},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.35370001196861267},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.3528999984264374},{"id":"https://openalex.org/C199033989","wikidata":"https://www.wikidata.org/wiki/Q1318295","display_name":"Narrative","level":2,"score":0.3447999954223633},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.3440999984741211},{"id":"https://openalex.org/C195094911","wikidata":"https://www.wikidata.org/wiki/Q14167904","display_name":"Process management","level":1,"score":0.33980000019073486},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.3345000147819519},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.3179999887943268},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.29350000619888306},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.2912999987602234},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.27320000529289246},{"id":"https://openalex.org/C137293760","wikidata":"https://www.wikidata.org/wiki/Q3621696","display_name":"Language model","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C198783460","wikidata":"https://www.wikidata.org/wiki/Q629173","display_name":"Management system","level":2,"score":0.2700999975204468},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.265500009059906},{"id":"https://openalex.org/C2776933761","wikidata":"https://www.wikidata.org/wiki/Q4117674","display_name":"Self-management","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.25870001316070557},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2529999911785126},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm66473.2025.11357237","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11357237","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W2032688904","https://openalex.org/W2041073071","https://openalex.org/W2339181429","https://openalex.org/W2924267632","https://openalex.org/W3170559591","https://openalex.org/W3184808400","https://openalex.org/W3199088499","https://openalex.org/W3217167023","https://openalex.org/W4232739596","https://openalex.org/W4365511237","https://openalex.org/W4391071805","https://openalex.org/W4403123342","https://openalex.org/W4405785232","https://openalex.org/W4405787555","https://openalex.org/W4406152280","https://openalex.org/W4408358959","https://openalex.org/W4409494261","https://openalex.org/W4409985349","https://openalex.org/W4412378274"],"related_works":[],"abstract_inverted_index":{"While":[0],"large":[1],"language":[2],"models":[3],"have":[4],"advanced":[5],"di-agnostic":[6],"reasoning":[7],"in":[8,71,77,110],"clinical":[9,230],"domains,":[10],"but":[11],"to":[12,165,180,221],"fully":[13],"support":[14],"the":[15,72,85,106,129],"patient":[16,94,198],"care,":[17],"accurate":[18],"and":[19,35,45,57,66,74,176,184,207,224,232],"personalized":[20,172,209],"treatment":[21,126,210],"(illness)":[22],"management":[23,38,79,99,112,174],"plans":[24],"are":[25,102],"also":[26],"needed.":[27],"Unlike":[28],"conventional":[29],"planning":[30,39,122,127],"tasks":[31],"with":[32,96,202],"defined":[33,64,143],"goals":[34,65],"constraints,":[36],"illness":[37,78,98,111,135,173],"navigates":[40],"through":[41],"uncertainty,":[42],"incomplete":[43],"data,":[44],"nonlinear,":[46],"cross-disease":[47],"effects.":[48],"As":[49],"a":[50,88,120,132,138,150,203,208],"result,":[51],"existing":[52],"methods":[53],"(e.g.,":[54],"Chain-of-":[55],"Thought":[56],"Reflexion),":[58],"which":[59,101],"rely":[60],"on":[61],"assumptions":[62],"of":[63,87,108,131,219],"linear":[67],"reasoning,":[68],"fall":[69],"short":[70],"complexities":[73],"ambiguities":[75],"inherent":[76],"planning.":[80,113],"Another":[81],"major":[82],"challenge":[83],"is":[84],"lack":[86],"high-quality":[89],"dataset":[90,195],"that":[91,124,154,170],"pairs":[92],"real-world":[93],"narratives":[95],"actionable":[97,185],"plans,":[100],"crucial":[103],"for":[104],"evaluating":[105],"capabilities":[107],"LLMs":[109],"To":[114,187],"address":[115],"these":[116],"challenges,":[117],"we":[118,191],"propose":[119],"novel":[121],"method":[123,213],"reconceives":[125],"as":[128],"modulation":[130],"patient's":[133],"current":[134],"state":[136,140],"toward":[137,158],"healthy":[139],"without":[141],"any":[142],"goal.":[144],"The":[145],"approach":[146],"introduces":[147],"Attractive":[148],"Tendencies,":[149],"latent,":[151],"directional":[152],"vectors":[153],"define":[155,171],"desirable":[156],"shifts":[157],"healthier":[159],"states,":[160],"then":[161],"uses":[162],"field":[163,178],"mapping":[164],"identify":[166],"modifiable":[167],"life":[168],"domains":[169],"goals,":[175],"applies":[177],"sculpting":[179],"generate":[181],"safe,":[182],"individualized,":[183],"interventions.":[186],"enable":[188],"standardized":[189],"evaluation,":[190],"release":[192],"an":[193],"evaluation":[194],"comprising":[196],"1,015":[197],"cases,":[199],"each":[200],"paired":[201],"real-world,":[204],"complex":[205],"narrative":[206],"plan.":[211],"Our":[212],"outperforms":[214],"baseline":[215],"approaches,":[216],"achieving":[217],"improvements":[218],"up":[220],"+12":[222],"BLEU-4":[223],"+11":[225],"METEOR,":[226],"while":[227],"maintaining":[228],"strong":[229],"relevance":[231],"computational":[233],"efficiency.":[234]},"counts_by_year":[],"updated_date":"2026-02-01T03:34:12.195049","created_date":"2026-01-30T00:00:00"}