{"id":"https://openalex.org/W7126068781","doi":"https://doi.org/10.1109/bibm66473.2025.11357170","title":"Exploring the Mechanism of Zuogui Pill in Recurrent Spontaneous Abortion Based on Network Pharmacology and Molecular Docking Technology*","display_name":"Exploring the Mechanism of Zuogui Pill in Recurrent Spontaneous Abortion Based on Network Pharmacology and Molecular Docking Technology*","publication_year":2025,"publication_date":"2025-12-15","ids":{"openalex":"https://openalex.org/W7126068781","doi":"https://doi.org/10.1109/bibm66473.2025.11357170"},"language":null,"primary_location":{"id":"doi:10.1109/bibm66473.2025.11357170","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11357170","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124196733","display_name":"Mousheng Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mousheng Hu","raw_affiliation_strings":["School of Traditional Chinese Medicine, Hubei University of Chinese,Medicine Wuhan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Hubei University of Chinese,Medicine Wuhan,China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124197274","display_name":"Jiawei Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Zhang","raw_affiliation_strings":["School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089295072","display_name":"Jinrong Zhang","orcid":"https://orcid.org/0000-0003-0774-8479"},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinrong Zhang","raw_affiliation_strings":["School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116766158","display_name":"Tongxuan Ouyang","orcid":null},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tongxuan Ouyang","raw_affiliation_strings":["School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069379051","display_name":"Hongming Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongming Huang","raw_affiliation_strings":["School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124171197","display_name":"Min Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Zhao","raw_affiliation_strings":["School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China","institution_ids":["https://openalex.org/I205016115"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I205016115"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"6692","last_page":"6699"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.18250000476837158,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.18250000476837158,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.1753000020980835,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5285999774932861},{"id":"https://openalex.org/keywords/pill","display_name":"Pill","score":0.4959999918937683},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"Mechanism of action","score":0.4779999852180481},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4318000078201294},{"id":"https://openalex.org/keywords/abortion","display_name":"Abortion","score":0.4142000079154968},{"id":"https://openalex.org/keywords/pubchem","display_name":"PubChem","score":0.34389999508857727}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5285999774932861},{"id":"https://openalex.org/C81603835","wikidata":"https://www.wikidata.org/wiki/Q3457430","display_name":"Pill","level":2,"score":0.4959999918937683},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4779999852180481},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4526999890804291},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4318000078201294},{"id":"https://openalex.org/C2778642596","wikidata":"https://www.wikidata.org/wiki/Q8452","display_name":"Abortion","level":3,"score":0.4142000079154968},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3856000006198883},{"id":"https://openalex.org/C158180186","wikidata":"https://www.wikidata.org/wiki/Q278487","display_name":"PubChem","level":2,"score":0.34389999508857727},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.3100000023841858},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.28119999170303345},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27900001406669617},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.26840001344680786},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.2671000063419342},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2653000056743622},{"id":"https://openalex.org/C2779746338","wikidata":"https://www.wikidata.org/wiki/Q6337803","display_name":"Neuroscientist","level":5,"score":0.2605000138282776},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2565999925136566}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm66473.2025.11357170","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11357170","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7929447293281555,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1969469693","https://openalex.org/W2834341622","https://openalex.org/W2922790865","https://openalex.org/W2935042348","https://openalex.org/W2963985015","https://openalex.org/W3021447523","https://openalex.org/W3029308626","https://openalex.org/W3097870112","https://openalex.org/W3107527779","https://openalex.org/W3193449201","https://openalex.org/W3199973499","https://openalex.org/W4224493681","https://openalex.org/W4281748131","https://openalex.org/W4282839909","https://openalex.org/W4315651980","https://openalex.org/W4390711247","https://openalex.org/W4390988215","https://openalex.org/W4392229985","https://openalex.org/W4393951191","https://openalex.org/W4401715178","https://openalex.org/W4404171643","https://openalex.org/W4404298853","https://openalex.org/W4404636106","https://openalex.org/W4410236829","https://openalex.org/W4413880973"],"related_works":[],"abstract_inverted_index":{"Objective]":[0],"To":[1],"investigate":[2],"the":[3,125],"mechanism":[4],"of":[5,7,84,95,129],"action":[6],"Zuogui":[8,19,103,130],"Pill":[9,20,104],"in":[10],"treating":[11],"recurrent":[12],"spontaneous":[13],"abortion":[14],"using":[15,42,87],"network":[16,37,71,112],"pharmacology.":[17],"[Methods]":[18],"components":[21],"and":[22,32,40,58,60,80,105,141],"their":[23],"respective":[24],"molecular":[25],"targets":[26,46,64,86,108,134],"were":[27,53,109],"identified":[28],"from":[29,55,102],"TCMSP,":[30],"HERB,":[31],"PubChem":[33],"databases.":[34],"A":[35,69,93],"component-target":[36],"was":[38,72],"constructed":[39,73],"visualized":[41],"Cytoscape":[43],"3.10.3.":[44],"Disease":[45],"related":[47],"to":[48,65],"Recurrent":[49],"Spontaneous":[50],"Abortion":[51],"(RSA)":[52],"retrieved":[54],"OMIM,":[56],"DisGeNET,":[57],"GeneCards,":[59],"intersected":[61],"with":[62],"drug":[63],"identify":[66],"common":[67],"targets.":[68,117],"PPI":[70,111],"via":[74],"STRING":[75],"database,":[76],"followed":[77],"by":[78],"GO":[79],"KEGG":[81],"enrichment":[82],"analyses":[83],"shared":[85],"<tex":[88,96],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[89,97],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\mathbf{R}$</tex>":[90],"software.":[91],"[Results]":[92],"total":[94],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\mathbf{6":[98],"3}$</tex>":[99],"active":[100,127],"ingredients":[101],"109":[106],"RSA-related":[107],"identified.":[110],"analysis":[113],"revealed":[114],"13":[115],"key":[116],"[Conclusion]":[118],"This":[119],"study":[120],"suggests":[121],"that":[122],"quercetin":[123],"is":[124],"main":[126],"component":[128],"Pill,":[131],"acting":[132],"on":[133],"such":[135],"as":[136],"AKT1,":[137],"IL6,":[138],"IL1B,":[139],"TP53,":[140],"TNF.":[142]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2026-01-30T00:00:00"}
