{"id":"https://openalex.org/W7126111824","doi":"https://doi.org/10.1109/bibm66473.2025.11356951","title":"Exploring the Mechanism of Dark Plum Combined with Licorice in Treating Allergic Asthma Based on Network Pharmacology and Molecular Docking*","display_name":"Exploring the Mechanism of Dark Plum Combined with Licorice in Treating Allergic Asthma Based on Network Pharmacology and Molecular Docking*","publication_year":2025,"publication_date":"2025-12-15","ids":{"openalex":"https://openalex.org/W7126111824","doi":"https://doi.org/10.1109/bibm66473.2025.11356951"},"language":null,"primary_location":{"id":"doi:10.1109/bibm66473.2025.11356951","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356951","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124194760","display_name":"Yiyi Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiyi Yang","raw_affiliation_strings":["School of Nursing, Hubei University of Chinese Medicine,Wuhan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Hubei University of Chinese Medicine,Wuhan,China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018203064","display_name":"Yujing Lyu","orcid":null},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujing Lyu","raw_affiliation_strings":["School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116766158","display_name":"Tongxuan Ouyang","orcid":null},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tongxuan Ouyang","raw_affiliation_strings":["School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069379051","display_name":"Hongming Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongming Huang","raw_affiliation_strings":["School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100401641","display_name":"Qian Zhang","orcid":"https://orcid.org/0000-0002-3859-6503"},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Zhang","raw_affiliation_strings":["School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124258090","display_name":"Ji Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210126517","display_name":"Wangjing Hospital of China Academy of Chinese Medical Sciences","ror":"https://ror.org/02fn8j763","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126517"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji Wang","raw_affiliation_strings":["Wang Qi Academy, Beijing University of Chinese Medicine,Beijing,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wang Qi Academy, Beijing University of Chinese Medicine,Beijing,China","institution_ids":["https://openalex.org/I4210165038","https://openalex.org/I4210126517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124171197","display_name":"Min Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Zhao","raw_affiliation_strings":["School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Hubei University of Chinese Medicine,Wuhan,China","institution_ids":["https://openalex.org/I205016115"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"6806","last_page":"6813"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.5361999869346619,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.5361999869346619,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.09109999984502792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13483","display_name":"Herbal Medicine Research Studies","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"Mechanism of action","score":0.6334999799728394},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"Allergic asthma","score":0.5730999708175659},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.560699999332428},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.478300005197525},{"id":"https://openalex.org/keywords/asthma","display_name":"Asthma","score":0.4713999927043915}],"concepts":[{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.6334999799728394},{"id":"https://openalex.org/C3020633164","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Allergic asthma","level":3,"score":0.5730999708175659},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.560699999332428},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4950000047683716},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.478300005197525},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.4713999927043915},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4607999920845032},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40939998626708984},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36910000443458557},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32659998536109924},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3000999987125397}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm66473.2025.11356951","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356951","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1684341504","https://openalex.org/W2034788356","https://openalex.org/W4407690920","https://openalex.org/W4407995508","https://openalex.org/W4410780826","https://openalex.org/W4411111516","https://openalex.org/W4411918188","https://openalex.org/W4412711066","https://openalex.org/W4412975046","https://openalex.org/W4413015263","https://openalex.org/W4413406082","https://openalex.org/W4413466373","https://openalex.org/W4413626795","https://openalex.org/W4413854568","https://openalex.org/W4413864992","https://openalex.org/W4413881814","https://openalex.org/W4413884104","https://openalex.org/W4413960236","https://openalex.org/W4414135940","https://openalex.org/W4414151997","https://openalex.org/W4414163704","https://openalex.org/W4414240803","https://openalex.org/W4414263762","https://openalex.org/W4414278164","https://openalex.org/W4414304069","https://openalex.org/W4414381484","https://openalex.org/W4414513041"],"related_works":[],"abstract_inverted_index":{"OBJECTIVE:":[0],"Based":[1],"on":[2],"network":[3],"pharmacology,":[4],"the":[5,10,35,54,57,65,75,106],"mechanism":[6,107],"of":[7,9,12],"action":[8],"combination":[11],"plum":[13],"and":[14,40,56,115],"licorice":[15],"in":[16],"treating":[17],"allergic":[18],"asthma":[19],"was":[20],"explored.":[21],"METHODS:":[22],"134":[23],"common":[24,51],"targets":[25,39,52,69,95],"were":[26],"identified.":[27],"Molecular":[28],"docking":[29,61],"confirmed":[30],"strong":[31],"binding":[32,72],"affinity":[33],"between":[34,53],"top":[36,66],"10":[37,67],"key":[38,68],"active":[41,76,85],"ingredients.":[42,77],"RESULTS:":[43],"Analysis":[44],"revealed":[45],"<tex":[46,79],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[47,80],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\mathbf{1":[48],"3":[49],"4}$</tex>":[50],"herb-pair":[55],"disease.":[58],"Furthermore,":[59],"molecular":[60],"analysis":[62],"demonstrated":[63],"that":[64],"exhibited":[70],"favorable":[71],"energies":[73],"with":[74,87],"CONCLUSION:":[78],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\boldsymbol{\\beta}$</tex>-Sitosterol":[81],"is":[82],"a":[83],"primary":[84],"ingredient,":[86],"TP53":[88],"as":[89],"its":[90],"direct":[91],"target.":[92],"Key":[93],"therapeutic":[94],"(e.g.,":[96],"STAT3,":[97],"TP53,":[98],"IL6,":[99],"TNF,":[100],"ESR1,":[101],"MAPK1,":[102],"AKT1,":[103],"MAPK3)":[104],"suggest":[105],"involves":[108],"suppressing":[109],"airway":[110,117],"inflammation,":[111],"modulating":[112],"immune":[113],"balance,":[114],"alleviating":[116],"remodeling.":[118]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2026-01-30T00:00:00"}